TruDiagnostic’s Post

In the recent paper published “Tau Modulation Through AAV9 Therapy Augments Akt/Erk Survival Signaling in Glaucoma Mitigating the Retinal Degenerative Phenotype,” researchers from Macquarie University, Sydney, Australia utilized MICRON ocular imaging technology to investigate the impact of Tau protein modulation on retinal neurons under normal and experimental glaucoma conditions.    As glaucoma remains a leading cause of blindness worldwide, understanding the underlying molecular mechanisms is crucial for developing targeted therapies. This work supported by MICRON technology, represents a significant step forward in elucidating the role of Tau in glaucoma pathology and highlighting the potential of Tau-targeted gene therapy approaches. Read more here: https://lnkd.in/gvdqhGAP

Neuroprotection: In a recent paper, the μ-opioid receptor, encoded by the Oprm1 gene, appears to be a neuroprotective factor for retinal ganglion cells. https://lnkd.in/dyuh-EHr #geneediting #neuroprotection #neurodegeneration

In vivo gene editing of HSC in bone marrow of mice via transient delivery of mRNA using lipid nanoparticle (LNP) without HSc transplantation and chemo.

New understanding of a gene that is linked to some forms of dementia and other age-related diseases gives scientists fresh hope that action can be taken against these diseases long before the onset of symptoms. The gene – called Angiogenin or ANG – is associated with a number of neurodegenerative diseases commonly associated with old age, including frontotemporal dementia (FTD), motor neuron disease (MND) and Parkinson’s disease. The ANG gene, associated with neurodegenerative diseases, affects the development of nerve cells. Mutated ANG delays differentiation of stem cells, leading to neurodevelopmental defects. Understanding ANG’s role could lead to early intervention and gene . https://lnkd.in/gT5btS-r

MSCs as a Pivotal Tool for Cell Therapy, Gene Therapy, and Tissue Engineering - https://lnkd.in/gv8tb7Sd MSCs have many fascinating properties, including strong immunomodulatory effects, the ability to repair damaged tissues, and the capacity in vitro to differentiate into other cells types. These traits, combined with their easy availability from different sources, has prompted researchers to look at MSCs as promising raw materials for use in cell therapy, gene therapy, and tissue engineering, the three pillars of regenerative medicine. The cumulative efforts of scientists, researchers and life science companies have resulted in the development of 10 MSC-based approved therapeutics and 19 MSC-based approved bone matrices. Read more at: https://lnkd.in/gv8tb7Sd #celltherapy #msc #genetherapy

Stem cells are not just the future; they're here to transform personalized medicine today! 💡 See how they're being used in drug development, disease modelling, and even gene therapy for tailored, effective treatments. Find out more: https://hubs.la/Q02kwJ3j0

Pancreatic islets are three-dimensional cell aggregates consisting of unique cellular composition, cell-to-cell contacts, and interactions with blood vessels. Cell aggregation is essential for islet endocrine function; however, it remains unclear how developing islets establish aggregation. By combining genetic animal models, imaging tools, and gene expression profiling, we demonstrate that islet aggregation is regulated by extracellular matrix signaling and cell-cell adhesion. Islet endocrine cell-specific inactivation of extracellular matrix receptor integrin β1 disrupted blood vessel interactions but promoted cell-cell adhesion and the formation of larger islets. In contrast, ablation of cell-cell adhesion molecule α-catenin promoted blood vessel interactions yet compromised islet clustering. Simultaneous removal of integrin β1 and α-catenin disrupts islet aggregation and the endocrine cell maturation process, demonstrating that establishment of islet aggregates is essential for functional maturation. Our study provides new insights into understanding the fundamental self-organizing mechanism for islet aggregation, architecture, and functional maturation. https://lnkd.in/eMC8EeWD

Stem cells are not just the future; they're here to transform personalized medicine today! 💡 See how they're being used in drug development, disease modelling, and even gene therapy for tailored, effective treatments. Find out more: https://hubs.la/Q02kwMmX0