The Hyve’s Post

Deciphering Cancer Cell Heterogeneity for Precision Medicine Single-cell ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing, scATAC-seq) is a relatively new and powerful technique that allows researchers to identify open chromatin regions and provides insight into the regulation of gene expression in individual cells. It has proven to be valuable for the study of cancer cell heterogeneity, understanding the regulatory landscape of individual cells, and exploring the molecular mechanisms underlying development and disease progression. #Cancer #Precision_Medicine #Labroot #science #Pharmacist #scientist

#HighlyCitedPapers 📝 Gene Expression Profiling in Early Breast Cancer—Patient Stratification Based on Molecular and Tumor Microenvironment Features — Munkácsy et al. In this paper, the authors aimed to evaluate the current evidence of using #gene expression signatures or profiling (GEP) in clinic and explore and discuss the increasing importance of immune parameters and the possibility to refine current tools with additional immune-GEPs that may help to refine prognosis and provide better predictive tools for early-stage breast #cancer. Full text is available 👇 https://lnkd.in/dxvmVf2x #medicine #health #research #science

📍 A database for single-cell variants map in human cancer    Yang et al. established a database, CanCellVar, which aims to provide and visualize the comprehensive atlas of single-cell variants in tumor microenvironment.     Key points  ✔ ∼3 million variants (∼1.4 million SNVs and ∼1.4 million A>G RNA edits) in 2,754,531 cells of 5 major cell types across 37 cancer types  ✔ The basic annotation information as well as cellular and molecular function properties of variants  ✔ The clinical relevance of variants including tumor grade, treatment, metastasis, and others  ✔ Tools to aid retrieval and to analyze cell-cell interactions, gene expression, cell-development trajectories, regulation, and molecular structure affected by variants. ➡ More details: https://lnkd.in/eUaDT9zp #harbinmedicaluniversity #spatialomics #spatialbiology #singlecellanalysis #singlecell

This textbook authored by the late Janis Kuby was my first introduction into immunology and how our body could fight cancer. I instantly became smitten with this area of study! Although Dr. Kuby lost her battle with cancer, I imagine if she could see how immunology has exploded to include CAR-T, CAR-NK, TIL, etc she would be so thrilled! Speaking of exploding, the team at Bio-Techne is really pleased about our recent app note partnering with Cell Signaling Technologies focused on: 1. CAR Construct Signaling Domain using #Jess 2. Cytokine Expression from Trangene using #Ella 3. CAR construct Expression with SimpleWestern using #Jess We even incorporated TcBuster for our non-viral gene editing along with our G-REX from #scaleready Analytical Tools to Evaluate CAR-T Cell Signaling & Activation | Bio-Techne #CellTherapy #CART #Innovation #Biotechne

Insights on the different researches done on Analysis of Breast Cancer transcriptome that revealed epigenetic based gene signature by #Fiona Okonjo ,PhD genetic profiling from liquid biopsy for adult tumors by #Pavanraj Chana,MD and a whole exome sequencing of breast cancers in AA,EA and kenyan patients by #Francis Makokha,PhD. Gene sequencing is proving to be among the most critical approaches in managing cancer #cancerresearch #kenyattauniveristy #intergratedcancerreearchfoundation

Gene Expression Profiling (GEP) is a laboratory testing method that measures which genes are being expressed in a cell at any given moment. Understanding the expression levels of certain genes for a specific type of cancer helps to create a molecular portrait of the cancer. This information can provide a deeper understanding of the biology of a tumor, which can vary from patient to patient, and can be utilized in several ways: to diagnose a disease or condition, understand response to therapy, or to provide prognostic information, all of which can guide clinical management decisions. #GEP #GeneExpressionProfiling #SkinCancerAwarenessMonth #DecisionDxMelanoma #DecisionDxSCC #MyPathMelanoma #DecisionDxUM

Discover how integrating spatial transcriptomics (ST) and bulk RNA-Seq provides unprecedented insights into the tumor microenvironment of non-small cell lung cancer (NSCLC). This study reveals the power of these techniques in understanding gene expression profiles, refining target expression by cell type, and identifying variability within tumors. Download our poster to learn more about this innovative approach and its potential for personalized therapeutic strategies. https://hubs.la/Q02zQzhl0 #NSCLC #SpatialTranscriptomics #RNASeq #PersonalizedMedicine