The Extracellular Matrix Pharmacology Congress’ Post

📢📄 [#PressRelease] May 30, 2024: Lys Therapeutics Announces Significant Scientific Advances in Neurodegenerative and Neurovascular Diseases With several #publications and oral #presentations at international medical conferences, Lys Therapeutics consolidates its scientific advances and demonstrates the quality of its research in the fields of #Stroke, #Parkinson's disease, and #MultipleSclerosis.   Lyon & Caen, France, May 30, 2024 – Lys Therapeutics, a pioneering French biotechnology company revolutionizing the treatment of patients with neurodegenerative and neurovascular diseases, today announces a series of scientific advances made public during the first half of 2024. These include six events (plenary presentations, oral communications, publications, and posters) where Lys Therapeutics presented major preclinical results in its two strategic areas: emergency medicine (including strokes) and neurodegenerative diseases (such as Parkinson's disease and multiple sclerosis). More information on https://lnkd.in/gwWwQ2rR

Hepatocellular carcinoma is a global burden. In this study funded by the Arab-German Young Academy of Sciences and Humanities (AGYA), which draws on financial support from the German Federal Ministry of Education and Research (BMBF), together with my dear colleague Maha Nasr and the dynamic vibrant team of collaborators, an innovative nano-based therapeutic construct was established. The natural plant-driven compound pterostilbene was loaded in dual targeted polymeric nanoparticles. Bearing two targeting moieties namely folic acid and lactobionic acid allowed for an outperformance over the free compound as delineated by the experiment at the cell line and animal levels. This studies opens the door for precision medicine. #nanomedicine #hepatocellularcarcinoma #targetedtherapy https://lnkd.in/dpPPfYfZ

Frontage and Telomir Pharmaceuticals recently presented promising pre-clinical data for Telomir‘s lead development product at the National University Health System of Singapore (NUHS) Centre for Healthy Longevity Conference 2024. The data highlighted the effect of Telomir-1 on telomere length in three human cell lines: MRC-5 fetal lung fibroblasts, human umbilical endothelial cells (HUVEC), and mesenchymal stem cells (MSC). Senior Scientist, Danielle Piazza Baker, PhD, of Frontage, presented the poster, titled “Telomir-1 Induces Telomere Extensions in Primary Human Cell Strains,” at the conference, which took place earlier this year. The data presented further demonstrated how Telomir-1 increases telomere length and its potential to successfully affect age-related inflammatory conditions. 👉 Learn more about this exciting news here: https://ow.ly/QcEj50R5IPL #drugdevelopment #preclinical #cro

Proud to share Selda’s new article on ruthenium-based photoactivated chemotherapy in ACS Journal of Medicinal Chemistry! Selda studied the interaction between the two photoproducts released upon light irradiation of a PACT compound: the photocage, and the anticancer drug. She realised her study a glioblastoma in vitro tumour model, where our target NAMPT protein is over-expressed. Strikingly, she found first that the ruthenium photocage is not necessarily as biologically inert as what is often believed, and second that the two photoproducts produced by light activation do interact biologically speaking. Importantly, this interaction depends on the oxygenation levels: In normoxia she found concentration-dependent interactions, while under hypoxia she found clear synergism. She also introduces an important distinction between on the one hand, the observation that two fragments may interact synergistically, and on the other hand, a high value of the photoindex. Well done Selda! and thanks to all co-authors who have contributed on this paper, and in particular Yurii who made large and pure batches of the compound so that the biologists can work with it ! Also thanks to Sylvia Le Dévédec from LACDR for this fruitful, long standing, collaboration. #leidenscience

There are so many rodent models available for preclinical target and drug discovery for #MASH. But which model offers the highest resemblance of the human disease?   The answer is simple. In the recent issue of Nature Metabolism, the renowned #LITMUS consortium concludes that Gubra’s GAN DIO-MASH mouse model ranks #1 for human proximity, a key indicator of clinical translatability, in terms of both metabolic relevance and ability to induce MASH-fibrosis. LITMUS compared a wide range of the most commonly used preclinical MASH models, evaluating their metabolic phenotype, liver histopathology and transcriptomics against corresponding MASH patient data.    We are very proud and grateful to be recognized by LITMUS as the provider of the most translational preclinical model.   Check out the paper and explore the objective ranking of preclinical models of MASH in the industry. #PreclinicalModel #PreclincalResearch #ClinicalTranslatability #MASLD #Publication #PreclinicalCRO #ResearchModels

Are you looking to tap into a unique genetic heritage and high-quality data to accelerate your research? Find research subjects faster, discover novel targets and biomarkers, and investigate with a multi-omic perspective. If so, then join this 30 September webinar for a dive into biomedical research with the Finnish biobanks. Click below to see the agenda and to register. #biobank #finbb #genomics #pharma #biomedical #research

In recent, Some paper was published as title is Intravital microscopy for real-time monitoring of drug delivery and nanobiological processes. This paper indicate that Intravital microscopy (IVM) expands our understanding of cellular and molecular processes, with applications ranging from fundamental biology to (patho)physiology and immunology, as well as from drug delivery to drug processing and drug efficacy testing. https://lnkd.in/gY9bRPGh

#SimpleWestern™ Testimonials: OLD-SCHOOL WESTERN BLOTS NOT CUTTING IT WITH PROTACS #PROTACs utilize the intracellular ubiquitinproteasome system to induce targeted protein degradation. A chimeric small molecule is designed with two “warheads”, one binds to the protein target of interest and the second binds to an E3 ligase. Both are joined by a flexible linker that brings the protein and ligase into close proximity. The ligase ubiquitinates the protein and targets it for degradation. This approach is getting attention in the field of targeted therapies, particularly in #oncology, as it has the potential of specifically eliminating targets from cells that previously proved undruggable. Rachel Doidge, Ph.D., a Senior Research Scientist, has been doing the studies with PROTAC target molecules at Aurelia. “When you’re working with PROTACs, Western blots are the standard manner of assessing compound potency,” she explained. “However, traditional Westerns are time consuming and only semiquantitative.” With traditional Western blot analysis, it took the team at Aurelia a good 24 to 48 hours – or longer – to get data. They were also going through lots of sample to get it.   SIMPLE WESTERN ON JESS STEPS UP THE ACCURACY ON DOSE RESPONSE Aurelia brought Wes into the lab several years ago, and he became a key technology very quickly. They recently upgraded and now have two #Jess™ systems in use pretty much full time. Jess and Wes are automated western blotting instruments from #ProteinSimple, called #SimpleWestern™. #automatedsolutions #biotechne #highthroughput https://lnkd.in/gQzxPVqm

𝗔𝗿𝗲 𝘆𝗼𝘂 𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝘄𝗶𝘁𝗵 𝗰𝗮𝗿𝗱𝗶𝗮𝗰 𝗺𝗼𝗱𝗲𝗹𝘀 𝗳𝗼𝗿 𝗽𝗿𝗲-𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗮𝘀𝘀𝗮𝘆𝘀? 𝗗𝗼𝗻’𝘁 𝗺𝗶𝘀𝘀 𝘁𝗵𝗲 𝘀𝗲𝗰𝗼𝗻𝗱 𝗲𝗱𝗶𝘁𝗶𝗼𝗻 𝗼𝗳 𝗟𝗮𝗯𝗜𝗡𝗔𝗥 𝗕𝗥𝗘𝗔𝗞 Join Dr. Ravi Vaidyanathan from FUJIFILM Cellular Dynamics, Inc for an enlightening webinar hosted by innoVitro. The webinar will explore how 2D and 3D co-culture systems enhance the relevance of these cell models, bridging the gap between lab research and clinical success. Here’s why you should attend: 🌱 Introduction to iCell cardiac fibroblasts: These high-purity cells exhibit low lot-to-lot variability and express specific markers like POSTN, TE7, and Cx43. 🧪 Enhanced co-culture models: Learn about co-culturing iCell Cardiomyocytes² with iCell Cardiac Fibroblasts and/or endothelial cells in 2D and 3D systems, providing advanced models for preclinical screening assays. If you're a researcher in cardiac physiology, drug discovery, or regenerative medicine, this webinar is for you. Make sure to save your spot! 🔗 Register here: https://lnkd.in/dht5JBxB #Cardiac #Fibroblasts #DrugDevelopment #PreclinicalResearch #HumanCellModels #Pharmaceuticals #Cardiomyocytes

A new interview on memo inHaematology! Anna Schuh presents her view on the recent and potential role of WGS in precision haematology and presents her personal congress highlights. Stay tuned for more congress content from ASCO, EHA and ICML 2023 including a new SPECIAL ISSUE coming soon! #EHA2023 #17ICML #ASCO #hematology #precisionmedicine #EHA #medicaleducation #cancerresearch