The Extracellular Matrix Pharmacology Congress’ Post

📢 EARLYBIRD ALERT 📢 This is your last chance to save up to $550 on your pass for the Bioelectric Medicine Development Summit. Register: https://ter.li/y4nf2p Join 80 neurostimulation experts from LivaNova, Axonics, Inc., Neuspera Medical Inc., Saluda Medical, ClearPoint Neuro, Inc., Cognito Therapeutics, Inc. and many more to discover novel strategies in obtaining funding, shortening clinical trials, approaching regulatory bodies, and overcoming reimbursement barriers. Furthermore, Vivek Pinto, PhD, MBA from the FDA will be talking on: 🧠 Overview of CDRH & Regulatory Pathways to Provide Novel Neuromodulation & Physical Medicine Devices to Patients 🖥 Panel Discussion: A Comparison of EU & US Regulations to Move Towards Global Harmonization View the full Event Guide HERE: https://ter.li/7vdix6 #neuromodulation #bioelectronics #brainstimulation #neurostimulation

The Osteoarthritis Research Society International Congress 2024 will take place in Vienna, Austria, from April 18 to 21. Our Chief Medical Officer, Professor francis berenbaum, is scheduled to deliver an oral presentation on Friday, April 19, 2024. His presentation is titled IN-MOTION: "Pioneering a Phase 2b Clinical Trial Tailored for Inflamed Phenotypes in Knee Osteoarthritis with Intraarticular Liraglutide." Also, Coralie Meurot, our preclinical research scientist, will present her poster titled "Intra-articular Administration of Liraglutide Mitigates Synovial Tissue Alteration and Cartilage Degradation in Preclinical Osteoarthritis Models" during the poster presentation session. #4P004 #clinicaltrial #OARSI #Biotech.

Cybin Inc's Two Deuterated Psychedelic Molecules Achieve Positive Topline Clinical Results, read more on the latest from Benzinga by Lara Goldstein. Features Cybin Inc, Doug Drysdale. #Psychedelics #PsychedelicsNews #Molecules #Study #BZCannabis.

Talks on acquisition of this platform by big pharmas, is on-going. Very interesting webinar on micro-spheres platform which have received FDA approval to encapulate oncolytic drugs for mutiple folds of bio-distribution to tissue/tumour of interest, with no more than innate immune response generated toxicity, and most importantly with maximum tolerated drug concentration delivered. The panel of speakers are touting this platform to rescue failed endpoints in phase 3 trials. Have a listen.

📅 Save The Date! 5th NovAliX Virtual Conference on November 30, 2023: Biophysics in Drug Discovery Developing the Synergy between Biophysics and Medicinal Chemistry to Deliver Better Drugs Exciting program to follow! #medicinalchemistry #biophysique #chimiemedicinale

Researchers have developed a pioneering once-a-day pill, SPG302, aimed at regenerating nerve cell connections damaged by ALS (amyotrophic lateral sclerosis). This drug, designed by Spinogenix, Inc., has been FDA-approved for ongoing clinical trials and is now being tested on ALS patients. ALS, also known as Lou Gehrig's disease, progressively damages motor neurons controlling muscle movements, leading to fatal muscle control loss. While current treatments only manage symptoms or slow progression, SPG302 offers a novel approach by focusing on synapse regeneration to restore neuron communication. Early-stage trials in Australia demonstrated that the drug is well-tolerated, leading to FDA approval for further trials in the US. This new phase aims to determine whether SPG302 can significantly improve ALS patients' lives by recovering lost motor and cognitive functions. Read more: https://lnkd.in/e3v3CZZA #medical #als #science #drugdevelopment #biology

Hepatocytes offer a physiologically relevant model for human translation of drug clearance and drug-drug interaction studies, but cell membranes can limit the entry of certain compounds, complicating translation.   Permeabilized hepatocytes offer an alternative way to utilize hepatocytes in research, with completely permeabilized plasma membranes, and intact subcellular organelle membranes. This maintains similar enzymatic activity, while allowing researchers to freeze, store and reuse material that would otherwise be lost.   Published in The AAPS Journal, the paper explores a novel method for optimizing hepatocyte permeabilization using saponin and details their value in providing mechanistic insights into liver metabolism and drug interactions.   Read more: https://rb.gy/puc71x   #Hepatocytes #CellModels #DrugDiscovery

Low price and fast track , correspndnace avaiaalble  Opportunity to add your name in research paper as co-author. Title:  Investigating the relationship between post-meal fluid intake abdominal obesity and gut health. Survey based study Journal Name: Journal of Population Therapeutics and Clinical Pharmacology  ISSN: 1710-6222 Indexing: HEC X Cat Cross Ref Google Scholar Paid Slot Available:  ,3rd, 5th 6th #dietitian #dietarysupplements #dietplan

WEBINAR THIS WEEK! Learn about advancements and the translational potential of 3D-modelled muscle microtissues for vascularisation and dynamic drug response in research and drug discovery. https://hubs.ly/Q0251x8h0 Dr Marieke Aarts from Bi/ond and Amanda Turner from bit․bio will explain how to generate 3D skeletal muscle microtissues that can be nourished, stimulated and monitored. They will also address the translational potential of Bi/ond's perfusable organ-on-chip technology for vascularisation and dynamic drug response for research and drug discovery. Discover how to: - Culture 3D muscle cell bundles on Bi/ond's perfusable organ-on-chip platform. - Measure muscle contractions triggered by electrical stimulation in ioSkeletal Myocytes™. - Apply this physiologically relevant, functional 3D system for pharmacological studies on wild-type and disease model cells. There is still time to register: https://hubs.ly/Q0251x8h0 #research #DrugDiscovery #neurodegeneration #DMD #3Dbiology #organonchip #myocyte #muscle #3D #cells #ioCells #optiox #webinar #technology SelectScience®