The Extracellular Matrix Pharmacology Congress’ Post

🌍 Exciting Times at the European #Workshop for Drug Design 2024! Dompé as part of the Ligate Project is thrilled to share highlights from the #EWDD24 held in the beautiful city of Siena, Italy. The conference was a remarkable success, providing a platform for pioneering discussions and collaborative learning within the scientific community. Dr. Akash Deep Biswas (PhD) presented groundbreaking work. We demonstrated the execution of over 16,442 molecular dynamics (MD) simulations, each lasting 250 nanoseconds, and binding free energy (BFE) calculations as part of the BAP Workflow. These simulations provide detailed insights into the behavior of molecules over time, aiding in the design of more effective drugs. Additionally, we completed over 8 million MD simulations, each 100 picoseconds long, and corresponding BFE calculations for the PS Workflow. These shorter simulations still offer valuable data on molecular interactions and are crucial for the rapid evaluation of potential drug candidates. These efforts underline the Ligate Project #commitment to advancing computational drug design, and it was inspiring to see such significant recognition and appreciation from our peers. A heartfelt thank you to the organizers and all participants for making this event so impactful. We are excited to leverage these insights to drive further innovation in drug discovery and development. #EWDD24 #DrugDesign #MDsimulations #BFEcalculations #LIGATE #Innovation #ScientificResearch #Networking #ML #AI #CADD #insilico #simulation

It was worthwhile waiting for the outstanding topic on every #DMDG Open Meeting, The Debate, this year the motion was: "This house believes that human will be the only species in DMPK evaluation by the 65th Open Meeting" Speakers FOR the motion: Beth Williamson PhD and Ian Wilson Speakers AGAINST the motion: Toby Athersuch and Steve Hood Moderator: Simon Taylor No doubt that I am FOR the motion since TNO is adhering to the 3R’s principle by offering predictive in vitro and ex vivo platforms predicting human PK/metabolism. Besides the pay-off of our TNO spin-off Peregrion is: Human first, human only. Generating hADME data early in #DrugDevelopment #TNO #Peregrion #DMPK #DrugMetabolism #3Rs

We're at SLAS! See our first poster presentation at 2pm EST and speak to one of the lead authors Dr Sian Humphreys. At 2pm EST today (Track: Cellular Technologies, poster session B) we're presenting our first SLAS poster titled "Differentiation of multiple iPSC lines to different cell types to enable cohort analysis in neurodegeneration: challenges and learnings". Tomorrow at 10am EST, we'll also be joined by our friends from Axion BioSystems at our booth (#224) to discuss iPSC technology, MEA, QC and phenotyping of advanced in vitro models. #iPSCs #SLAS #biotech #StemCells #DrugDiscovery

Congratulations to the authors of this week's Publication Spotlight! Alan Courteau, John McGrath, Paul Michael Walker, Benoît Presles, Ruslan Garipov, Alexandre Cochet, François Brunotte, Jean-Marc Vrigneaud The use of preclinical simultaneous PET/MR imaging systems is on the rise, transitioning from physicists to pharmacology and biology experts. However, these combined scanners are susceptible to artefacts and performance deviations due to external factors or subsystem interference, potentially affecting image quality and data accuracy. Quality assurance is essential to prevent the loss of animals and experiments. To streamline this process, simple daily tests have been developed over the past 5 years for easy implementation by experimenters with limited technical expertise. Additional periodic tests are recommended for comprehensive system maintenance, using cost-effective materials for accessibility. The data was acquired on a MRS*DRYMAG 7T with an integrated PET insert system at the Preclinical imaging platform - Centre Georges François Leclerc. The article was published in Molecular Imaging and Biology in 2022. The publication is available at: https://lnkd.in/eaXWVBbp #MRI #PET #calibration

We’re excited to share the last in our series of new visualizations, “Competition”, as featured on our website: https://lnkd.in/eVNt6F4a. This graphic shows how ErythroMer’s use of a lipid nanoparticle to encapsulate and regulate Hb addresses the shortfalls of first-generation, unencapsulated HBOCs.   In terms of competition, the standard of care is blood – a type-specific and perishable liquid that requires refrigeration, cold-chain, and use within about a month, so there have been many attempts to develop a substitute with more ideal features that improve upon these limitations. Attempts to date have failed due to two main reasons: (1) Poor oxygen delivery, and (2) Safety and efficacy issues that ended FDA trials.   ErythroMer was specifically designed to fix these issues, and we have a growing set of preclinical data to support its future use in humans. In studies to date, we are demonstrating safety and efficacy in preclinical studies – in vivo, ex vivo, and in vitro. None of the first-generation HBOC attempts are viable for use in trauma, and other technologies in development either lack ideal features or are far behind us in development.   Created by Fabian de Kok-Mercado, at Discoveries Brought to Life, LLC.

A friend asked me “Simon, what’s up with your large-scale multi-omics 🧬 presentation tomorrow at NextGen Omics conference??” We’re struggling with a proper single-omic workflow!! Well, the future of precision medicine 💊 is there and patients can’t wait. We all have family members and friends who want to live a better life. ❤️ ⏰ When: Tomorrow 9:40 AM. Make sure to swing by booth #17 and meet the Code Ocean team to have a chat, grab some of our latest swag, or see a demo! #bioinformatics #nextgenomics #biotech

Are you involved in drug development? Then don't miss our upcoming webinar! Patrick O'Meara from the Critical Path Institute (C-Path) will be presenting this Thursday about the value of the drug development information management systems developed and used within ERA4TB, to enable streamlined access to and integration of data. His presentation will be one of three alongside talks from Silvia Grandoni from Consiglio Nazionale delle Ricerche on the use of computer modelling , and Juan Jose Vaquero from Universidad Carlos III de Madrid on the use of imaging biomarkers within #tuberculosis research. Don't miss out, register for the webinar today! https://lnkd.in/eGks_sbP This webinar will be hosted by NICE - National Institute for Health and Care Excellence, partner member of ERA4TB. #preclinicalresearch #earlystageresearch #tuberculosisresearch #TBresearch #clinicalresearch #imaging #imagingbiomarkers #drugdevelopment #datamanagement

Why should you choose Somark's identification methods for your research practices? 1️⃣ Compliant - Universal IACUC/Ethics approvals 2️⃣ Unique and individual - Over 3 million mice identified so far 3️⃣ Integrated - LinkTo can be used to integrate with existing laboratory systems and platforms 4️⃣ Permanent - ID's which are assured to last the lifetime of the lab rodent during their study involvement, even longitudinal studies. Transform your institute or organizations preclinical research with Digitail, Labstamp or both! Get in touch now [email protected] #laboratoryprocesses #researchorangisation #preclinical

Join us for this #ORS2024 Scientific Workshop! In this workshop, attendees will gain insights into challenges stemming from clinical trials involving nerve growth factor (NGF) inhibitors and more. Learn more about this workshop and others: https://bit.ly/3tMX6Xg

#ASCO2024 with some of my favorite people. Meet our amazing BostonGene team in beautiful Chicago. Stop by booth #22157 to learn more about our AI-powered multiomics platform, which accelerates new research and drug development while precisely matching each patient with the best available therapy. Reach out and let me know if you would like to setup a meeting with our R&D or clinical team. 🧬🥼📊 Angela Peterson Leslie Cropper #AI-powered #multiomics #biomarkerdiscovery #spatialproteomics #analytics