Saint Francis Healthcare System’s Post

🧠🔬 New insights into #Alzheimer’s! 🐭 Study reveals key changes in the kidney & spleen of 3xTg-AD mice, highlighting the importance of a systemic approach🧫🩸🔗@MDPIOpenAccess https://mdpi.com/2813936 #mdpiijms via @IJMS_MDPI

We now know that HF is not just a cardiac disorder and inflammation is one of the main contributors, but not all inflammatory biomarkers are helpful for assessing HF prognosis. Platelet-to-lymphocyte ratio (PLR) is one of them showing conflicting results and we should still wait for the further data. So, check out our recent publications regarding the effect of PLR on HF outcomes, this time also as the corresponding author. Thanks to all of our outstanding colleagues (Niloofar Bondariyan, Sayed Ali Emami, Mehrnaz Shakarami, Farbod Khanizadeh, Ph.D.(Maths), davood shafie, Shahin Sanaei, etc.) See the following link and cite as appropriate: https://lnkd.in/g8uHK7zJ #heartfailure #inflammation #article #metaanalysis #systematicreview #cardiology #cardiovasculardisease #biomarkers

A short story about Long QT Syndrome (LQTS),part three. LQTS1 and LQTS2 account for the majority of all LQTS cases(e) and 10% is due to LQTS3. LQTS1 and LQTS2 are caused by mutations in genes that encoding the ion channel for the potassium current,the mutations can cause the channels to be blocked completely, open after a delay, or close prematurely, thus causing decreased potassium outward current and a longer duration of repolarization. Increased sympathetic stimulation can provoke arrhythmias in LQTS1 and LQTS2 patients. Key point: In LQTS1, exercise (especially swimming) and emotional stress can precipitate syncope and sudden cardiac death,while arrhythmic events in LQTS2 can occur at stress or rest; triggering by unexpected loud noises (e.g. alarm clock) is very suggestive of LQTS2. LQTS3 is caused by mutations of the SCN5A sodium channel gene, leading to delayed closing of the channel, a constant inward sodium current, and prolonged repolarization. Key point: 1)Individuals with LQTS3 tend to experience cardiac events while sleeping. 2) In addition to rapid ventricular arrhythmias, in LQTS3 ,the syncopal events can also be associated with bradycardia #cardiology #Long_QT_Syndrome

𝐂𝐡𝐚𝐧𝐠𝐢𝐧𝐠 𝐭𝐡𝐞 𝐩𝐚𝐫𝐚𝐝𝐢𝐠𝐦 𝐨𝐟 𝐡𝐞𝐚𝐫𝐭 𝐩𝐫𝐞𝐬𝐞𝐫𝐯𝐚𝐭𝐢𝐨𝐧 – 𝐰𝐢𝐭𝐡 𝐡𝐲𝐩𝐨𝐭𝐡𝐞𝐫𝐦𝐢𝐜 𝐨𝐱𝐲𝐠𝐞𝐧𝐚𝐭𝐞𝐝 𝐩𝐞𝐫𝐟𝐮𝐬𝐢𝐨𝐧. 𝐍𝐞𝐰 𝐇𝐎𝐏𝐄 𝐟𝐨𝐫 𝐡𝐞𝐚𝐫𝐭𝐬. Listen to Drs. Filip Rega, Paul Jansz and Jacob Schroder at ISHLT - International Society for Heart and Lung Transplantation- 2024 when they share their insights on heart preservation. Heart transplantation procedures have been evolving since the first heart transplant was performed in 1967. Over the years, scientific and clinical advancements have been made, but limitations such as time, distance, and the availability of donor hearts have been constant constraints. Now, there is new hope for hearts. Hypothermic oxygenated perfusion of hearts has accumulated experience across three continents and eleven countries. Listen to experts present groundbreaking clinical results and share their experiences. Mark your calendars: 📅 When: Friday, April 12 at 11:45-12:45 CEST 📍 Where: Panorama Hall #hearttransplant #transplant #extendinghorizons #heart #HOPEforhearts #ISHLT2024

Happy to share our most recent research, soon to be published in Sleep Medicine, delving into the relationship between Obstructive Sleep Apnea and Cancer. ✅ #OSA severity significantly impacts the overall prognosis of oncologic disease ✅ Nocturnal #hypoxia is associated with higher mortality regardless of #cancer subtype or primary site ✅ Higher hypoxic burden translated into worse prognosis irrespective of staging and cancer treatment 𝗟𝗶𝗻𝗸: https://lnkd.in/dgdWku2p ⏳ Next up, should we be looking at OSA/NH as 𝘁𝗿𝗲𝗮𝘁𝗮𝗯𝗹𝗲 𝘁𝗿𝗮𝗶𝘁𝘀 in our cancer patients to possibly improve overall outcomes?

October 26th marks the World Amyloidosis Day, a day for connecting the amyloidosis community to the general public. #Amyloidosis is a rare and complex disease which is barely known by the general public and medical professionals alike. The objective for World Amyloidosis Day, organized by Amyloidosis Alliance and patient organisations from 18 different countries, spanning 4 continents, is to alert the world to the diagnostic delay that patients face, which averages 4 years. Faster diagnoses and better quality treatment can only be acheived by more widespread knowledge of the disease. #Amyloidosis #RareDiseases #Cardiology #AmyloidosisAlliance

Congratulations to Drs. Michael Foley, Rasha Al-Lamee, and all investigators for completing the randomized, sham-controlled ORBITA-COSMIC trial! 👏 The trial results have shown that Coronary Sinus Reducer therapy significantly reduces symptoms in patients with symptomatic coronary microvascular disease. 🌟 Following the COSIRA study, this is the second sham-controlled trial confirming the therapy's effectiveness. Evidence in the study suggests epi-to-endo flow redistribution, offering a new understanding of symptom improvement beyond traditional definitions of angina. 📈 These insights offer a new layer of hope for many patients experiencing symptoms like shortness of breath not always recognized as angina. VahatiCor is committed to support the management of symptomatic coronary microvascular disease, building a robust body of clinical evidence for patient benefit. Read more on these groundbreaking results on our website article. Link in the comments. #Cardiology #ORBITACOSMIC #microvascular #angina #CoronarySinusReducer #MedicalResearch #CardiacCare #HealthcareInnovation

🔥 Hot off the press! 🔥 We're thrilled to share a groundbreaking new article published in AoH: Coronary artery disease as a risk factor for metabolic dysfunction-associated steatotic liver disease and liver fibrosis". In this pioneering study, the authors explore the intricate link between coronary artery disease (CAD) and liver health, shedding light on how CAD can elevate the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis. This research is a significant step forward in understanding the complex interactions between heart and liver diseases. 🎥 Watch Dr. Vega discuss his findings and their implications in this brief video! Full text 😜 🔗 https://lnkd.in/gR2ves7d #Hepatology #LiverHealth #Cardiology #CoronaryArteryDisease #MedicalResearch #AnnalsOfHepatology

#cancer #lymphoma #chemo #effects #bronchoscopy #update #life #love #reverenceforlife #loveofJesus My dear friends, as I wait for the rain in south Alabama to abate enough to permit dog walking, (my two dogs, although poodles by breed and ostensibly water loving canines, in actuality hate getting wet), allow me to furnish interested parties with an update on my post chemo infusion situation. First as to lingering side effects. The last chemo infusion occurred two months ago. Still lingering to plague me are the following: neuropathy, in the form of occasional unsteadiness and weakness, lack of energy, usually in the morning; inappetence, but at least the nausea and inability to even to contemplate food ingestion have lessened; lower limb tumescence; and skin flakiness. As to procedures, you will recall that the pt scan revealed 99% cancer liberation, but a couple of troublesome spots remained. To analyze those trouble spots a bronchoscopy (tissue extraction) was set up, but the presiding anesthesiologist wanted first an updated echocardiogram, then a statement from my cardiologist that I was, in the opinion of that professional, fit for anesthesia. I have been informed by the office of the pulmonologist to be performing the bronchoscopy that such a statement has been provided to the anesthesiologist. Its contents and reception have not been vouchsafed unto me, but I am scheduled for the procedure on August 1, then a visit with the oncologist on August 19 (this to give all the labs time to conduct and analyze the biopsy of the tissues resulting from the procedure). Accordingly on/about August 19 I should know whether I am 100% cancer free, or whether the remaining spots will require radiation to help me attain that promised land! I am most grateful for all your prayers and good wishes, and I trust this short recapitulation of my protocols, trials, and tribulations will be of assistance to anyone experiencing this disease and treatment in the future. Cum meo maximo amore!

This study reveals promising results for cardio-oncology rehab among high-risk cancer survivors. Center-based cardiac rehab (CBCR) showed superior cardiorespiratory fitness & cardiovascular risk control compared to community-based exercise training (CBET). https://ja.ma/48LwdTo