Robert Plenge’s Post

🔬Exciting News! 📚 I am thrilled to announce the publication of our latest paper, "Targeting Angiotensinogen With N-Acetylgalactosamine–Conjugated Small Interfering RNA to Reduce Blood Pressure," authored by Dien Ye, Edwyn O. Cruz-López, Ho-Chou Tu, Ivan Zlatev, and A.H. Jan Danser. 📅 Published: October 19, 2023 📖 Journal: Arteriosclerosis, Thrombosis, and Vascular Biology Read the full open access on: https://lnkd.in/edXMPn5T Our paper provides a comprehensive review of AGT small interfering RNA in preclinical models, comparing it to classical RAS blockade with ACE inhibitors, AT1 receptor antagonists, and AGT suppression with antisense oligonucleotides. We also address the latest information about clinical trials and safety of this novel antihypertensive approach. #Hypertension #MedicalResearch #HealthcareInnovation 🩺💡

An excellent new addition to our capabilities in BioPharma. This new laboratory could help us learn much more about the genetics of diseases in respiratory and immunology, providing many promising new targets for our R&D pipeline. #RandD #Innovation #Respiratory #Immunology

This is what is needed to succeed in drug discovery space.

Are you interested in the past, present, and potential future applications of discovery biology to better understand mechanisms of and therapeutic targets for #osteoarthritis? Grateful to be included in this thoughtful review describing what we have learned and how to leverage advances in #proteomics, #transcriptomics & #metabolomics in OA, led by Mohit Kapoor out now in Osteoarthritis and Cartilage Journal. We speculate on what the future can hold - including the exciting potential value of spatial and multi-omics approaches! Shoutout to the awesome team behind this important contribution: Farooq Rai, Annemarie Lang, Tristan Maerz, Ph.D., Jeroen Geurts, Cristina Ruiz Romero, Ron June, Yolande F. M. Ramos, Sarah Rice, S. Amanda Ali, PhD, Chiara Pastrello, Igor Jurisica, Tom Appleton, MD PhD, Jason Rockel, PhD https://lnkd.in/g9YbqBQm PDF available by request.

📢I am very happy and proud to share our latest research article! In this study, we aimed to systematically investigate the differences between fetal and adult Mesenchymal Stromal Cells (MSCs) and MSC-derived Extracellular Vesicles (EVs) at the phenotypic, RNA, and protein levels. I specially thank to Cecilia Götherström for being a great and supportive mentor! 💐 Thanks all authors for their effort and contributions! Yuk Kit Lor, Fawaz Abomaray, PhD, Samir EL Andaloussi, Maria Pernemalm, Nidhi Sharma, Daniel W Hagey, André Görgens, Manuela O Gustafsson, Katarina Le Blanc, Mawaddah Asad Toonsi, Lilian Walther Jallow, Cecilia Götherström 🔎 Key findings: -Fetal MSCs are in a more undifferentiated state at the transcriptomic, proteomic, and cellular levels, and that they possess a greater bone formation and regenerative capacity compared to adult MSCs. -We also show that the active pathways in fetal and adult MSCs are distinctly different, mirroring their developmental origin and potential in regenerative medicine. #stemcells #stromalcells #extracellularvesicles #proteomic #transcriptomic

Spatial analysis is crucial for understanding diseases such as cancer and neurodegeneration by highlighting the importance of cellular variation and structural organization. Explore best practices in spatial biology through our infographic to enhance your research. https://lnkd.in/gvpeqJvP

Join Our Upcoming Webinar on Liver Bile Duct Development! 📅 Date: May 1 ⏰ Time: 9:00 AM Pacific 🌐 Registration: https://parse.bio/3Umr9jb Delve into the complexities of liver bile ducts with Emory University's Gracz Lab! In this webinar, Hannah Hrncir will discuss findings from their recent study. What You'll Learn: ➡ The exciting work being done in the Gracz Lab at Emory University. ➡ How scRNA-seq identified gene-expression defects in ductule-like biliary epithelial cells (BECs). ➡ More about Parse Biosciences' single-cell platform, Evercode. #webinar #singlecell #research

IsoPlexis is now Bruker Cellular Analysis! Follow Bruker Cellular Analysis to get updates on technologies revealing true functional immune biology, and accelerating biomarker discovery and development. https://hubs.ly/Q02HbPk10

We were thrilled to welcome Dr. Ashleigh Riegler, a Postdoctoral Research Fellow at the University of Alabama at Birmingham, to our NanoString Technologies Customer Experience Lab. Dr. Riegler has been tirelessly working on the front lines of COVID-19 research, focusing specifically on Mycology in intubated COVID-19 patients with secondary mold infections. During her visit, she dove deeper into our CosMx SMI technology, which she is utilizing in her groundbreaking research. She is using our platform to spatially study iron concentrations in relation to these fungal infections, seeking to understand the crucial role that iron plays in infection outcomes. Her innovative approach includes comparing the gene expression of iron-loaded versus iron-low macrophages to gain new insights and hopefully develop more effective treatments. We are proud to support such important research and excited to see the results of Dr. Riegler's work. Stay tuned for more updates! #biotechnology #research #covid19 #mycology #geneexpression #nanotechnology #ironresearch #NanoStringTechnologies #CosMxSMI #CustomerExperienceLab #UAB This post may include information regarding CosMx™ SMI products for RNA detection, which products are not available in the member states of the European Unified Patent Court, as further described here - https://bit.ly/498JPIB.

From cellular biology to immunotherapy development, experience and leverage Quantitative Flow Cytometry using the QIFIKIT®. Download flyer to learn more: https://lnkd.in/giyDY9s5