More exciting news from Paratus Sciences and our partners at Duke-NUS Medical School as we continue to define the potential of #batbiology to improve human health! https://lnkd.in/gN6bdSQW
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Clinical Biochemist | Dual Master's in Digital Health and Public Health Management | COVID-19 Expert | Leader in Clinical Diagnostics | Published Scientist.
A study in Science Translational Medicine reveals that the risk of prolonged severe COVID-19 varies among immunosuppressed individuals. The research, led by Yijia Li, M.D., from Harvard Medical School, emphasizes the importance of understanding immune defects influencing persistent COVID-19 across various immunosuppressive conditions. #COVID19Research #Immunocompromised #SARSCoV2 #HealthStudy #Immunosuppression #MedicalResearch
Prolonged SARS-CoV-2 Risk Varies Across Immunosuppressive Conditions
healthday.com
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The National Human Genome Research Institute (NHGRI)-funded Electronic Medical Records and Genomics (eMERGE) Network has recently published their framework and pipeline to deliver polygenic risk score (PRS) data in a general population setting. Benefits of PRS-based risk assessment include reducing the burden of a range of conditions through targeted interventions and preventative measures. The eMERGE investigators conclude “The potential impact of PRS-based risk assessment in clinical practice is substantial.” The geneType clinical product offering currently overlaps with five of the diseases within the eMERGE study. Erika Spaeth, Scientific Director of geneType says, “A study of this size is a wonderful advancement for the utility of polygenic risk. We believe that the future of personalized medicine will incorporate polygenic risk into population healthcare, but we take our clinical approach one step further and believe that polygenic risk is a more powerful tool in combination with other clinical risk factors.” geneType is involved in similar studies on a smaller scale, currently being carried out with investigators in Australia and we are working hard to be part of the progression of personalized healthcare. Learn more about this landmark #precisionmedicine study: https://lnkd.in/eq82NvXP #AllOfUs #KnowYourRisk #PRS
Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations - Nature Medicine
nature.com
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Small study shows abnormal immune-cell activity with #longCOVID Story on Center for Infectious Disease Research and Policy (CIDRAP) Study in Science Translational Medicine #COVID19 #COVID19Aus https://lnkd.in/dwWhhrq4
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A Deep Dive into COVID-19's Complex Interactions with the Complement System! Karel Van Damme and researchers from Ghent University and Université libre de Bruxelles have unveiled groundbreaking findings in the realm of COVID-19 pathogenesis. With the support of the Chan Zuckerberg Initiative, their research in Science Magazine's Science Translational Medicine titled "A complement atlas identifies interleukin-6–dependent alternative pathway dysregulation as a key druggable feature of COVID-19" is reshaping our understanding. Top Insights from the paper: • Complement dysregulation correlates with COVID-19 severity. • IL-6 emerges as a pivotal regulator of complement production and is identified as a significant upstream regulator of complement responses. • The alternative complement pathway is a major player in COVID-19 pathogenesis and stands out in its role. • Collaboration between liver and local complement factors is crucial, highlighting the system's multifaceted role in COVID-19. • Complement C5 inhibition offers promise in reducing disease severity and provides a ray of hope in treatment. It's science! The journey to understanding and conquering COVID-19 is paved with challenges, but with each scientific breakthrough, we move closer to solutions. #COVID19 #ComplementSystem #ChanZuckerbergInitiative
A complement atlas identifies interleukin-6–dependent alternative pathway dysregulation as a key druggable feature of COVID-19
science.org
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🌐 A host–microbiota interactome reveals extensive transkingdom connectivity🧬 The myriad of microorganisms living in symbiosis with humans have a profound impact on human physiology, yet the intricate details of these influences at the molecular level remain largely uncharted. While classical pathogens are known to infiltrate host tissues, altering immune defenses by engaging with human extracellular and secreted proteins (the 'exoproteome'), the interactions between commensal microbes and the host exoproteome have been less explored. Introducing 🌟 BASEHIT 🌟 - A pioneering technology developed to probe the extensive landscape of human exoproteome-microbiome interactions at a proteome-wide scale. Leveraging BASEHIT, researchers have examined over 1.7 million potential interactions between 519 bacterial strains, representing a wide array of phylogenies and tissues, and 3,324 human exoproteins. This investigation has revealed a vast network of transkingdom connectivity, uncovering thousands of previously unknown interactions involving 383 bacterial strains and 651 host proteins. The intricate pattern of interactions observed suggests a complex underlying biological logic, with strains of the same species displaying similar exoprotein-binding patterns and tissue-specific strains associating with corresponding exoproteins. Further analysis has identified unique, often strain-specific interactions that may play critical roles in niche colonization, tissue remodeling, and immune modulation. Interestingly, strains with diverse profiles of interaction with the host exhibited distinct behaviors in vitro with host cells and elicited varied responses from the host immune system in vivo. This groundbreaking work sheds light on a vast, previously unexplored domain of molecular-level interactions between the human microbiota and their hosts, potentially laying the groundwork for new understandings of how indigenous microorganisms influence human health and disease. link: https://lnkd.in/gst-Zaiq #ScienceInnovation #MicrobiomeResearch #HealthTech #ScientificBreakthrough #MicrobiomeDiscovery #InnovativeBASEHIT
A host–microbiota interactome reveals extensive transkingdom connectivity - Nature
nature.com
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Your recurring ear infection may be the result of bacteria evading the antibiotics you're taking. Why is this happening and how can AI help? 👩🏻💻 Jacqueline Valeri, a recent graduate of MIT Jameel Clinic - AI & Health faculty lead Jim Collins' lab, explains how researchers used AI to discover that an existing drug called semapimod could be repurposed for targeting hard-to-kill, "sleeper" bacteria, including A. baumannii, one of the most antibiotic-resistant pathogens in clinical medicine. “For Gram-positive infections, we need better drugs, but for Gram-negative infections we need any drugs.” Valeri is the first author of this paper on semapimod, which was published in the March print issue of Cell Press Chemical Biology. Paper: https://lnkd.in/eA5FYjKP MIT News: https://lnkd.in/erWuExZr #aiforgood #aiforhealth #machinelearningsolutions #antimicrobialresistiance
When an antibiotic fails: MIT scientists are using AI to target “sleeper” bacteria
news.mit.edu
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🔬Exciting News for Scientists!🔬 Introducing: Nature Springer’s Borrelia burgdorferi: Methods and Protocols. Methods in Molecular Biology. Editor Leona Gilbert. https://lnkd.in/dyW8d6V6 📚 From cell and molecular biologists to statisticians and clinical researchers, these methods cater to all fields. Explore techniques for in vitro, in vivo, in situ, de novo, and clinical studies of Borrelia burgdorferi. Let's advance our understanding of infectious diseases! 💪🌍 Chapter 6 Revealed. 🔬 New Advances in Lyme Disease Diagnosis! 🌿 Colleagues from ArminLabs bring light to the complexities of diagnosing Lyme borreliosis. While traditional ELISA tests have been a staple for detecting antibodies against Borrelia burgdorferi, they must be more foolproof. Variations in Borrelia species and their different effects across global populations have made a one-size-fits-all approach to testing challenging. TICKPLEX aids in serology testing by testing immune responses against various species of Borrelia and its persistent forms. The EliSpot Lyme assay is designed to reveal the T cell response to Borrelia infection. This test is a useful, particularly for patients who don't produce enough antibodies to be detected by standard serological tests, often leading to misdiagnosis or delayed treatment. The EliSpot assay paired with TICKPLEX ELISA bridges a gap, integrating humoral (antibody-mediated) and cellular (T cell-mediated) immunity to provide a fuller picture of the body’s response to infection. Stay informed on the latest in Lyme research and diagnostics. #LymeDisease #MedicalInnovation #Healthcare #AdaptiveImmunity #Science #BorreliaBurgdorferi #ResearchMethods #InfectiousDiseases #LymeDisease #ScienceDiscoveries #TickbornePathogen #TickborneDisease #ScienceAdvances #TickBorneDiseases #Tickplex www.tezted.com www.arminlabs.com
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Let's shed light on the sophisticated interplay between T cells, interleukins, RANKL, and osteoclasts in their pivotal roles in periodontitis. This paper published by Prof. Jose R. Gonzales, delves into the nuanced contributions of T cells in the immune landscape of periodontal disease, emphasizing the balance between pro-inflammatory and anti-inflammatory interleukins. 🔬 Key Highlights: T cells orchestrate a delicate balance in periodontal health, influenced significantly by interleukins, which can either escalate or alleviate the inflammatory response. Pro-inflammatory interleukins, often triggered by certain T cell subsets, can exacerbate periodontal damage by promoting inflammation and tissue degradation. Conversely, anti-inflammatory interleukins play a crucial role in regulating T cell responses, potentially mitigating the severity of periodontitis by reducing inflammation and protecting periodontal tissues. Understanding this intricate interaction opens up new avenues for targeted therapeutic strategies, aiming to modulate the immune response to prevent excessive inflammation while bolstering the body's natural defense mechanisms against periodontal disease. Could this be the key to more personalized, effective periodontal care? https://lnkd.in/gmTQPZku #Periodontitis #Immunology #TCells #Interleukins #InflammationManagement #DentalResearch
T- and B-cell subsets in periodontitis - PubMed
pubmed.ncbi.nlm.nih.gov
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