National Institute of Allergy and Infectious Diseases (NIAID)’s Post

Scientists have known for decades that malaria infection is associated with high levels of autoantibodies—antibodies that are associated with autoimmune disorders like systemic lupus erythematosus (SLE). In a recent paper, NIAID researchers and their colleagues examine the molecular mechanisms of these autoantibodies, and show how the autoantibodies which are associated with SLE today could once have served a purpose as a defense against malaria. Learn more: https://go.nih.gov/O2rTs4a

  • Colorized scanning electron micrograph of red blood cell infected with malaria parasites (blue). The small bumps on the infected cell show how the parasite remodels its host cell by forming protrusions called 'knobs' on the surface, enabling it to avoid destruction and cause inflammation. Uninfected cells (pink) have smoother surfaces.

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