OUR MISSION AND CREDO AT WORK – Improving lives together A breakthrough solution under development in Canada seeks to provide alternate therapeutic options for pain management and insomnia, and is making huge strides under the leadership of a consortium of experts, including #McGillUniversity, #CQDM (an R&D incubator non-profit organization), the #brainCanadaFoundation, Evotec SE, the Quebec Government and the full engagement of #MINAKEM Montreal. This transformative research is issued from the work conducted by #GabriellaGobbi, MD, PhD, Professor of Psychiatry at McGill, in 2007. The new treatment option could transform pain management, replacing opioids-type medicines with higher risk profiles, as well as help enable durable deep sleep phases for insomnia patients. Through the effective coordination of CQDM, the consortium was able to join strengths and push forward a quality of life changing solutions for patients. This project is soon to enter first trial phases on humans. #healthcareinnovation #medicalresearch #breakthroughresearch #painmanagement #insomnia #sleephealth #qualityoflife #patientsfirst #clinicaltrials
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Faculty, University of Victoria, Teacher Trainer, Project Facilitator, EMI Consultant, Business Owner
I look forward to reading their reports when they finish this important research #tbi
It is estimated that approximately 165,000 people per year experience a traumatic brain injury (TBI) in Canada, and that by 2031, TBI is projected to be among the most common neurological conditions affecting Canadians. Because of the high numbers of people living with TBI, contrasted with the lack of resources to match the demand for services, people with brain injury are at a high risk of missing a critical window of opportunity for recovery. Through the Innovation Grants for Research Impact in Traumatic Brain Injury program, Brain Canada and Brain Changes Initiative are funding research to improve brain health in Canada. We are thrilled to introduce the recipients of this year's grants! Congratulations to Dr. Carolina Bottari from Université de Montréal, Dr. DJ Cook from Queen's University and Dr. Chantel Debert from University of Calgary, as well as Dr. Sandy Shultz from Vancouver Island University. Learn more about their projects ➡️ https://lnkd.in/gpD4aDUP #TBIresearch - Chaque année, environ 165 000 personnes subissent un traumatisme cranio-cérébral (TCC) au Canada. D’ici 2031, les TCC devraient figurer parmi les troubles neurologiques les plus répandus au sein de la population. Le nombre élevé de victimes de TCC et le manque de ressources pour répondre à la demande de services font en sorte que les chances de se rétablir d’un TCC sont gravement compromises. Grâce au programme Subventions à l’innovation pour l’impact de la recherche sur les traumatismes cranio-cérébraux, la Fondation Brain Canada et Brain Changes Initiative financent des recherches qui ont le potentiel d’améliorer la santé cérébrale de la population canadienne. Nous sommes ravis de vous présenter les lauréats des subventions de cette année ! Félicitations à Carolina Bottari de Université de Montréal, DJ Cook de Queen's University, Chantel Debert de University of Calgary, ainsi que Sandy Shultz de Vancouver Island University. Pour en savoir plus sur leurs projets ➡️ https://lnkd.in/gVCH6pRx
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Longitudinal population-based research reveals associations between prenatal SSRI exposure and brain development from childhood to adolescence. https://ja.ma/3L2rYJ0
Prenatal Antidepressant Exposure and Offspring Brain Morphologic Trajectory
jamanetwork.com
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May be we need to add Free T3 in routine labs, TSH with or without free T4 is not enough! "It is important to note that the more typically measured biomarkers for thyroid function (T4 and TSH) are poorly linked to free T3 levels," Lawton and colleagues wrote. The ratio of TSH:T4 explained only 1.7% of variation in T3 levels, they noted, which suggested that TSH and T4 may not be accurate surrogates of free T3. Thus, "direct measurement of free T3 is likely vital to properly stratify the effects of HPT-axis variation," https://lnkd.in/gBt_4hTK #thyroidhealth #depression #psychoneuroendocrinology #hormones #health #primarycare #psychiatry
Direct Measurement of T3 Is Likely Vital, Say Researchers
medscape.com
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New Danish study looking at risk of psychiatric and neurological diagnoses after COVID-19. https://lnkd.in/dzTPUcs6 https://lnkd.in/dmZthqfe It is nice to see our prior findings being reproduced with updated data also finding that the increased risk of neuropsychiatric disorders is driven by infection severity - and that the increased risk after COVID-19 resembles the increased risk for neuropsychiatric disorders observed after other respiratory infections with similar severity. https://lnkd.in/dyr6NXPC https://lnkd.in/gSzNBBWf #COVID-19, #Psychiatry, #Neurology, #MentalDisorders, #Cognition"
Stort dansk coronastudie giver ny viden om senfølger
nyheder.tv2.dk
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👉 Do you know neuropathy can be caused by various factors in your life? Knowledge is the first step to managing and reversing it! 1️⃣ Chronic Alcohol Consumption 🍷: Alcohol has a toxic effect on nerve tissue, which over time can cause nerves to deteriorate or become damaged. This damage can disrupt the normal functioning of the peripheral nerves, leading to chronic pain, tingling, and numbness. 2️⃣ Vitamin B12 Deficiency 💊: Vitamin B12 is essential for nerve health as it helps maintain the myelin sheath that protects nerve fibers. Without enough B12, this protective layer can degrade, causing nerve signals to slow down or become faulty, leading to neuropathy. 3️⃣ Injury or Surgery 🤕🔪: Any physical trauma can directly damage the nerves, disrupting their ability to transmit signals. Post-surgical neuropathy can also occur if nerves are inadvertently damaged during operations. 4️⃣ Hypothyroidism 🦋: This condition affects your metabolism and can result in fluid buildup in tissues which may exert pressure on peripheral nerves. Prolonged pressure can cause these nerves to malfunction, resulting in neuropathic symptoms. 5️⃣ Certain Infections 🦠: Viruses and bacteria can cause inflammation or direct damage to nerves. For example, shingles can cause severe nerve damage in the affected area. Lyme disease, diphtheria, botulism, HIV can all cause varying degrees of nerve damage leading to neuropathy. 6️⃣ Vasculitis 🔥🩸: Inflammation of blood vessels can restrict blood flow to nerves, depriving them of oxygen and nutrients. This lack of nourishment can cause nerves to become damaged or die, leading to neuropathy. If you or someone you know is dealing with neuropathic symptoms, drop a comment with "Aware" below! #NeuropathyAwareness #HealthJourney #KnowledgeIsPower #ChiropractorClinic #HealthJourney #WindsorChiropractor #ColoradoChiropractor #AlthoffWellnessClinic #neuropathy #medications #neuropathyhurts #neuropathysucks #neuropathyfighter #neuropathypain #neuropathyawareness #neuropathytreatment #neuropathywarrior #neuropathyrelief #footpainrelief #footpainsucks #nervepain #painreliever #reduceinflammation #naturalpainrelief #nervepainawareness
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Gestational exposures have enduring impacts on brain and neuroimmune development and function. Perturbations of pregnancy leading to placental structure/function deficits, cell stress, immune activation, and endocrine changes (metabolic, growth factors, etc.) all increase neuropsychiatric risk in offspring. The existing literature links obstetric diseases with placental involvement to offspring neuroimmune outcomes and neurodevelopmental risk. Psychoneuroimmune outcomes in offspring brain include changes to microglia, cytokine/chemokine production, cell stress, and long-term immunoreactivity. These outcomes are altered by structural, anti-angiogenic/hypoxic, inflammatory, and metabolic diseases of the placenta. This fetal programming occurs via direct placental passage or production of factors which can act directly on fetal brain substrates, or indirectly via action of circulating factors on intermediates in the placenta. Placental neuroendocrine, vascular/angiogenic, immune, and extracellular vesicular mechanisms are detailed. These mechanisms interact within various placental and pregnancy conditions. An increased understanding of the placental origins of psychoneuroimmunology will yield dividends for human health. Identifying maternal and placental biomarkers for fetal neuroimmune health may also revolutionize early diagnosis and precision psychiatry, empowering patients to make the best healthcare decisions for their families. Targeting placental mechanisms may be a valuable approach for the prevention and mitigation of intergenerational, lifelong neuropathology. Gumusoglu SB, Brain Behav Immun Health. 2024 Feb 6;36:100735. doi: 10.1016/j.bbih.2024.100735. PMID: 38420039; PMCID: PMC10900837 #Gesundheit #Bildung #Fuehrung #Coaching #Mindset #Motivation #Gehirn #Neuroscience #Psychologie #Persoenlichkeitsentwicklung #Kindheit #KeyNoteSpeaker #Humangenetik #Biochemie #Neuroleadership #Ernaehrung #Transformation #Stress #Demografie #Gender #Age #interkulturelleKompetenz #Epigenetik #Veraenderung #EmotionaleIntelligenz #Change #Gesellschaft #Organisationsentwicklung #Philosophie #Beratung # Quantum
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A new study led by UCLA neurologist Dr. Rhonda Voskuhl sheds light on the underlying mechanisms linking menopause to cognitive deficits and brain atrophy. Published September 28, 2023, the study reveals that both aging and estrogen loss were critical to cognitive deficits in women. This critical body of work confirms the effect of menopause-related cognitive decline and prompts the need for additional studies to address preventive measures and support for women during this critical life stage. Read the full study by visiting cleopatrarx.com. https://bit.ly/3F5wjHS #menopause #cognitivehealth #cognitivedecline #brainhealth #neurodegeneration
Menopausal hormone changes linked to cognitive deficits
eurekalert.org
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Excited to share our latest #research #article! Free access for 50 days to our new study showing that amniotic cortisol predicts multiple growth and developmental outcomes in healthy, non-stressed macaques 🐒 This is important research that is nearly impossible to do in humans, because pregnant people are generally only referred for an amniocentesis for karyotyping/genetic concerns -- it's not done in standard populations. We show that fetal cortisol exposure, as measured by amniotic cortisol, predicted neonatal growth and brain development, and cognitive development later in infancy. https://lnkd.in/ej5uNWbH
Amniotic fluid cortisol predicts neonatal and infant development in non-stressed rhesus monkeys: Implications for prenatal stress
sciencedirect.com
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Some new articles posted In Press in the Archives of PM&R Effect of inspiratory muscle training on cough strength in older people with #frailty: a single-blind randomized controlled trial from Tatsuya Morishita, Shusuke Toyama, Kazuaki Suyama, Fumiya Nagata, Masatoshi Itaki, Takako Tanaka, Shuntaro Sato, Yuji Ishimatsu, Terumitsu Sawai, Ryo Kozu At https://lnkd.in/eTWCH-fT #Psychometric properties of the Pictorial Pain Interference Questionnaire for Assessing Functional Interference in Chronic #LowBackPain from Marta Moreno-Ligero, María Dueñas, Inmaculada Failde, Rogelio Del Pino, M Carmen Coronilla, Jose A. Moral-Munoz At https://lnkd.in/ennQABG2 The Effects of #ShockWaveTherapy on The Symptoms and Function of Patients with Dupuytren's Disease; A #SystematicReview from Amid Yazdani Researcher, Parsa Nasri Researcher, Sadegh Baradaran Mahdavi Physiatrist, Clinician-Scientist, Researcher At https://lnkd.in/eg3-bswY Effectiveness of #balance #exercise and brisk #walking on alleviating non-motor and motor symptoms in people with mild-to-moderate Parkinson's Disease: A randomized clinical trial with 6-month follow-up from Margaret K.Y. Mak, Irene S.K. Wong-Yu, Roy T.H. Cheung, Shu-Leong Ho At https://lnkd.in/ejABkEk2 Utilization and potential disparities in access to #physicaltherapy for #spine #pain in the long-term care population from Rachel A Prusynski, Laura S Gold, Sean D Rundell At https://lnkd.in/eFx3i3rW Digital self-management, analgesic use and patient-reported outcomes in #knee or #hip #osteoarthritis from Armaghan Mahmoudian, L Stefan Lohmander, Leif E Dahlberg, Ali Kiadaliri At https://lnkd.in/ewdetk9x #rehabilitation #physiatry #ACRM #parkinsons #PRO #patientreportedoutcome #DupuytrensDisease
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