Join us on Tuesday, June 25th, for a live webinar on Phenotypic Disease Modeling for Inflammation: Advancing Immune-targeting Therapies! Presented by Lenie van den Broek, Director Biology Discovery at MIMETAS, this webinar will dive into the complexities of immune-targeting therapies and how innovative 3D disease modeling is impacting drug discovery. 💡 What you'll learn: - Case study on mechanism of action and antibody ranking in vascular inflammation assays - Using complement activated serum in immune-competent renal models - Capturing key IBD mechanisms with adult stem cell-derived gut organoid models - Benefits of partnering with MIMETAS to accelerate your research and improve the selection of your immunomodulatory compounds - Be the first to learn about our new product, the OrganoReady® Colon Organoid 🔗 Register now: https://lnkd.in/edQbawru #Webinar #DrugDiscovery #Inflammation #ImmuneTherapies #3DModeling
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Are you tired of the tedious and error-prone methods of isolating lymphocytes from whole blood? Uni-Sep is here to simplify your lab workflow and deliver accurate results. ✅ Ready-to-use and sterile, Uni-Sep ensures a safe process with minimal contact with biological fluids. ✅ Say goodbye to time-consuming sample preparation – just pour your blood sample directly into the tube. ✅ Enjoy maximum yields of viable mononuclear cells, all while handling multiple samples simultaneously. No more painstaking layering, lengthy centrifugation, or careful cell harvesting with pipettes. Uni-Sep's innovative plastic membrane prevents layers from mixing, allowing you to pour blood directly into the tube without disrupting the separation medium layer. This means faster, easier, and more efficient processing of a large number of samples at once, reducing centrifugation time and simplifying lymphocyte isolation. Ideal for genetics, immunology, and oncology research, Uni-Sep guarantees consistent and accurate mononuclear cell isolation. It's time to elevate your research game! #UniSep #ResearchMadeEasy #ScienceSolutions #LabInnovation #EfficiencyMatters #ResearchSimplified
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Starving cancer cells by depleting specific amino acids, such as cysteine, can expose the vulnerabilities of cancer cells, leading to enhanced DNA damage and better responses to DNA repair-targeted and immune-based therapies. This strategy creates oxidative stress, disrupts glutathione synthesis, and amplifies reactive oxygen species levels, ultimately increasing cancer cell death. Combining amino acid depletion with agents targeting antioxidant defenses further boosts cytotoxicity in prostate cancer cells. #CancerResearch #Biohacking #Immunotherapy #DNARepair #HealthTech Read more here: https://lnkd.in/eMTqV_3C BioMedHack.com is your leading source for the latest news, breakthroughs, and insights in medicine, biohacking, and alternative medicine. Our mission is to help you live healthier and longer by bringing you cutting-edge information and expert advice. Follow us on Facebook, Instagram, and X.
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🧬 FixNCut: new Single-cell RNAseq protocol 🎉 A recent study titled "A Novel Single-cell RNA-sequencing Method Pushes the Boundaries of Research and Clinical Care in Pancreatic Cancer" has just been published in Gastroenterology by Aney and colleagues. 🚀 The study introduces FixNCut, a method that employs reversible fixation to overcome the limitations posed by pancreatic digestive enzymes. This technique pauses RNase, DNase, and protease activities, enabling high-definition transcriptomic profiles of pancreas cells. It's a big step forward in tackling pancreatic diseases! 📖 Gastroenterology paper: https://buff.ly/3vBBo9O 📢 Join the Conversation 📢 Share your ideas, methods, and tools in the comments! 👇 💬 #PancreaticCancer #SingleCell #RNAseq #Bioinformatics #Biotechnology #FixNCut #ClinicalResearch
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Access our on-demand webinar to learn about how scientists are leveraging single-cell epigenomics assays like ATAC-seq, whole transcriptome assays and image-based spectral sorting to drive deep immunology discovery. Watch now: https://bit.ly/3LfsiU6 #epigenomics #transcriptomics #spectralflowcytometry #ATACseq #singlecellmultiomics #BDRhapsody #BDBiosciences
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Check out our new paper on MUC5AC expression to diagnose pancreatic cancer. Reviving old biomarkers for new purpose
Differential Expression and Diagnostic Value of MUC5AC Glycoforms in Pancreatic Ductal Adenocarcinoma
mdpi.com
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Looking for an innovative liver model for your drug discovery and research endeavors? Register for our upcoming webinar this November 28, where our Early Stage Researcher, Flavio Bonanini, will be presenting liver tissue and disease modeling capabilities at MIMETAS, focusing on our comprehensive 3D human liver model and it's diverse array of applications. Key highlights will include: - A state-of-the-art, 3D in vitro liver tissue and disease modeling incorporating multiple cell types, including hepatocytes, liver endothelial cells, stellate cells and immune cells - Explore key applications of our liver model, including fibrosis, steatosis and other metabolic assays - Key findings of a fully automated and multiplexed anti-fibrotic drug screening project Register here: https://lnkd.in/eB5d8GjW #livermodel #diseasemodeling #liverfibrosis #liverresearch
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NASH Drug R&D Challenges We understand the debilitating challenges faced by patients. With more than 15 years of experience in immunology, inflammation, and metabolic disease models, we are committed to providing novel and high-quality solutions to our partners in new drug discovery. Developing NASH treatments is tough due to complex mechanisms and low patient response rates. Histological evaluation has limitations. Our novel NASH model accelerates preclinical studies, saving time and costs. It's clinically translatable, and validated with reference drugs. Partner with us for innovative NASH solutions. 👉 Download the 13-page ebook now: https://lnkd.in/gBq7KmMA #NASHResearch #BioDuroSundia #Discovery #NASHDiscovery
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https://lnkd.in/djsZ9Y9d PRECAME Study: Preventing cardiovascular effects with metformin in obese patients ( Corpori Sano Biotechnology, Brasil 🇧🇷 2002 ): " Insulin resistance sensitizers or modulators: Therapeutic link between human metabolism, cardiovascular system and cancer " " Drug that modulates mitochondrial, endothelial and DNA-telomere function " " A new therapeutic approach in cardiovascular, metabolic and oncological prevention " " Creating a scientific basis for an infinite possibility of future studies and research " " Specific therapy, to live healthily " " Scientific research that studies the basis of the iceberg of cardiovascular disease " " Through innovative medicines for public health and committed to bringing better health and a better future for patients, translating science and regenerative medicine into medicines that change for human lives, as the main objective " PRECAME Study and Walter's Metabolic Theory, improving the perspective and quality of life of patients " #science #ciencia #cancer #oncology #obesity #
Integrated Pharmacodynamic Analysis Identifies Two Metabolic Adaption Pathways to Metformin in Breast Cancer
sciencedirect.com
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