The Michael J. Fox Foundation for Parkinson's Research’s Post

📃Scientific paper: Interactions Between Astrocytes and Oligodendroglia in Myelin Development and Related Brain Diseases Abstract: Astrocytes (ASTs) and oligodendroglial lineage cells (OLGs) are major macroglial cells in the central nervous system. ASTs communicate with each other through connexin (Cx) and Cx-based network structures, both of which allow for quick transport of nutrients and signals. Moreover, ASTs interact with OLGs through connexin (Cx)-mediated networks to modulate various physiological processes in the brain. In this article, following a brief description of the infrastructural basis of the glial networks and exocrine factors by which ASTs and OLGs may crosstalk, we focus on recapitulating how the interactions between these two types of glial cells modulate myelination, and how the AST-OLG interactions are involved in protecting the integrity of the blood-brain barrier (BBB) and regulating synaptogenesis and neural activity. Recent studies further suggest that AST-OLG interactions are associated with myelin-related diseases, such as multiple sclerosis. A better understanding of the regulatory mechanisms underlying AST-OLG interactions may inspire the development of novel therapeutic strategies for related brain diseases. Continued on ES/IODE ➡️ https://etcse.fr/kHFVZ ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Research Topic Update: Extended Submission Deadlines for Oxytosis/Ferroptosis Study in Neurodegenerative Diseases! Manuscript Summary: 29th February 2024 Manuscript Submission: 31st March 2024 Submission Link: https://lnkd.in/gSa9wEKv Frontiers We welcome your contributions in the form of incisive research, review articles delving into oxytosis/ferroptosis and its pivotal implications in neurodegeneration. This Research Topic offers an invaluable opportunity to dissect the intricate mechanisms of this field and exchange profound insights, The broad areas to be covered are: 1️⃣ Iron Homeostasis and Lipid Peroxidation: Investigate the intricate interplay between oxidative stress, iron regulation, and lipid peroxidation in neurodegenerative disorders. 2️⃣ Disease-Specific Exploration: Uncover oxytosis/ferroptosis nuances in Alzheimer's, Parkinson's, and Huntington's diseases, illuminating their disease-specific impacts. 3️⃣ Advances in Neuroprotection: Showcase recent strides in identifying agents targeting oxytosis/ferroptosis, offering potential avenues for therapeutic development. 4️⃣ Cutting-Edge Tools and Techniques: Discuss state-of-the-art tools—from omics approaches to imaging—that aid in pinpointing therapeutic targets and biomarkers. 5️⃣ Role of Glial Cells: Examine the crucial role of glial cells in modulating oxytosis/ferroptosis, presenting implications for therapeutic strategies. This is your chance to contribute to the advancement of oxytosis/ferroptosis research. Let's deepen our understanding of neurodegenerative diseases and explore avenues for effective treatments. Submit now: [https://lnkd.in/gSa9wEKv] #neurodegeneration #neurodegenerativediseases #Neuroscience #Oxytosis #Ferroptosis #ScientificResearch

TODAY, I delivered the keynote address at the 9th Neurological Disorders Summit (NDS-2024) in Barcelona, Spain in a session chaired by Laxman Gangwani which also featured Moussa Youdim. What an amazing opportunity to speak about the #PasinettiLab's work "AD-derived bone marrow transplant induces proinflammatory immune peripheral mechanisms accompanied by decreased neuroplasticity and reduced gut microbiome diversity affecting AD-like phenotype in the absence of Aβ neuropathology". Surprisingly, I was given the award for most outstanding keynote presentation. A huge honor that I am so proud to have received. Immune system dysfunction is increasingly recognized as a significant feature that contributes to #AlzheimersDisease (AD) pathogenesis, reflected by alterations in central and peripheral responses leading to detrimental mechanisms that can contribute to the worsening of the disease. The damaging alterations in the peripheral immune system may disrupt the peripheral-central immune crosstalk, implicating the #Gut #Microbiota in this complex interaction. I spoke about the central hypothesis of our study which posits that the immune signature inherently harbored in bone marrow (BM) precursor hematopoietic cells can be transferred through allogeneic transplantation, influencing the recipient's immune system and modulating peripheral, gut, and brain immune responses. Our investigation shed light on the pivotal role of the peripheral immune system in the brain-gut-periphery axis and its profound potential to shape the trajectory of #Alzheimers. Finally, I spoke about how our study advances our understanding of the complex interplay among the peripheral immune system, brain functionality, and the gut #Microbiome, which collectively influence AD onset and progression, and how this paves the way for future studies. If you missed my presentation, Learn More about this study - "AD-derived bone marrow transplant induces proinflammatory immune peripheral mechanisms accompanied by decreased neuroplasticity and reduced gut microbiome diversity affecting AD-like phenotype in the absence of Aβ neuropathology" 👉 Brain, Behavior, and Immunity https://lnkd.in/dDakHNiq Learn More about the NDS-2024 Summit https://lnkd.in/eDPaCXD7

By examining 4,979 proteins across five independent cohorts with our high-plex SomaScan Assay, Tony Wyss-Coray's team from Stanford University School of Medicine discovered "a simple and interpretable method" to understand how organ aging is linked to accelerated risk for diseases like Alzheimer's, heart failure, and more. Using a small blood sample from 5,676 adults, the team discovered that plasma proteins can model organ aging. Some insights from the publication: 🔎 "nearly 20% of the population show strongly accelerated age in one organ" 🔎 "Accelerated organ aging confers 20-50% higher mortality risk" 🔎 "individuals with accelerated heart aging have a 250% increased heart failure risk" 🔎 "A molecular understanding of human organ aging is of critical importance to address the massive global disease burden of aging and could revolutionize patient care, preventative medicine and drug development." Learn more on our website: https://somalogic.com/ New to proteomics? Start here: https://lnkd.in/gFM5BNGC #aging #ageing #biomarkers #proteomics #neuroscience #cardiology

Join InnoSer in raising awareness for Parkinson’s disease!  April 11th marks Parkinson’s disease awareness day, with the whole month of April being dedicated to raising awareness of this devastating neurodegenerative disease. The global prevalence of Parkinson’s disease has doubled in the last 25 years, leading to global increases in disabilities and death as a result of this neurological disease.  Current Parkinson’s disease therapies focus on relieving disease symptoms rather than preventing disease progression. New and more powerful therapeutic approaches targeting disease pathology are needed to address the disease development and severity of Parkinson’s disease.  Multiple in vitro and in vivo models have been generated to evaluate the efficacy and safety of such novel treatments. However, different experimental models recapitulate distinct pathophysiological features of Parkinson’s disease. Therefore, selecting the most appropriate model for your specific research question is crucial to advancing the development of targeted therapeutics.  Together with our neurology study directors Jolien B. and Thomas Vogels we have recently put together a blog post discussing all available in vitro and in vivo Parkinson’s disease models that InnoSer offers. Click here to discover how your research can benefit from InnoSer’s preclinical expertise and experience in modelling neurodegenerative diseases such as Parkinson’s: https://lnkd.in/ePZzn5dF  #ParkinsonsDiseaseAwareness #ParkinsonsDisease #NeurodegenerativeDisease #Neurodegeneration #Neuroinflammation #NeuroscienceCRO #CRO

By examining 4,979 proteins across five independent cohorts with our high-plex SomaScan Assay, Tony Wyss-Coray's team from Stanford University School of Medicine discovered "a simple and interpretable method" to understand how organ aging is linked to accelerated risk for diseases like Alzheimer's, heart failure, and more. Using a small blood sample from 5,676 adults, the team discovered that plasma proteins can model organ aging. Some insights from the publication: 🔎 "nearly 20% of the population show strongly accelerated age in one organ" 🔎 "Accelerated organ aging confers 20-50% higher mortality risk" 🔎 "individuals with accelerated heart aging have a 250% increased heart failure risk" 🔎 "A molecular understanding of human organ aging is of critical importance to address the massive global disease burden of aging and could revolutionize patient care, preventative medicine and drug development." Learn more on our website: https://somalogic.com/ New to proteomics? Start here: https://lnkd.in/gFM5BNGC #aging #ageing #biomarkers #proteomics #neuroscience #cardiology

🚀 Breakthrough in Neurodegenerative Disease Research! 🚀 CHARM is out!! https://lnkd.in/e4WQXS55 Small recap : 1️⃣ Some diseases propagate not through viruses or microbes, but through proteins that induce neurodegenerative diseases, like prion diseases (e.g., mad cow disease). 2️⃣ It might be that other neurodegenerative diseases, such as Parkinson's, propagate in a similar way according to the Braak hypothesis. 3️⃣ If you are interested in the development of this research, which started in the 1950s with the description of kuru, check out Prion Science and Its Unsung Heroes by Adriano Aguzzi: 🔗 Science, 18 Jan 2024, Vol 383, Issue 6680, DOI: 10.1126/science.adn9424 https://lnkd.in/e6yX4_xX 4️⃣ A new epigenetic editor that silences prion protein brainwide via AAV delivery, published on June 28, 2024, opens the way for exciting new therapeutics. 🧬✨ 🥳👏 #Neuroscience #Epigenetics #PrionDiseases #Neurodegeneration #Innovation https://lnkd.in/e4WQXS55

🧠 New study by Libri et al. investigates the impact of the APOE genotype on blood-brain barrier (BBB) integrity among 230 participants experiencing cognitive impairment. It utilizes cerebrospinal fluid (CSF)/serum albumin ratios and CSF/serum kappa and lambda free light chains (FLCs) as indirect markers of BBB permeability, offering insights into the pathophysiology of neurodegenerative diseases. 💡 Key findings: 🕐 Elevated CSF/serum albumin and FLCs ratios were observed, indicating increased BBB permeability in individuals carrying the APOE ε4 allele, particularly pronounced in Alzheimer's disease patients. This finding underscores the allele's potential role in neurodegeneration. 🕑 Heterozygous and homozygous carriers of APOE ε4 exhibited a dose-dependent increase in BBB permeability, reflecting a genetic influence on BBB function. 🕒 The association of APOE ε4 with BBB permeability highlights its importance not only in Alzheimer's disease but also in broader neurodegenerative conditions, suggesting areas for future research in therapeutic interventions. For more details: https://lnkd.in/dDEkz29v #Neuroscience #Bloodbrainbarrier #APOE4 #CognitiveImpairment #AlzheimersDisease

😃 Review Sharing-Welcome reading and download... 👉 Title: T-cell based immunotherapies for Parkinson's disease 🤵 Author: Rodrigo Pacheco 🔎 DOI: https://lnkd.in/ggPzyv86 This work summarizes and discusses a number of experimental immunotherapies that aim to strengthen the Treg response or to dampen the inflammatory T-cell response as a therapeutic approach in animal models of Parkinson's disease. #ParkinsonsDisease, #Neuroinflammation, #Neurodegeneration, #Tcells, #RegulatoryTcells, #AlphaSynuclein, #Immunotherapy