MaxWell Biosystems’ Post

We are thrilled to be back at #SfN2023 in Washington, DC, in about 3 months! We are proud to showcase our team of experts and their cutting-edge research with the following abstracts: 🔹Characterizing the maturation of electrophysiological properties in stem cell-derived human neurons lacking methyl CpG binding protein 2 (MECP2). 🔹Patch clamp profiling the functional properties of human iPSC-derived nociceptors. 🔹High-density MEA recording of primary rat neuron cultures and human iPSC-derived neuron cultures growing at low density on astrocyte feeder layers. 🔹Establishment of a preclinical migraine model based on nitroglycerine (NTG)-induced sensitization of spinal trigeminal parabrachial (TPB) neurons in the anesthetized rat. We are looking forward to engaging with fellow researchers, exchanging knowledge, and contributing to the advancements in neuroscience. Visit us booth 2422 at #SfN2023 to learn more about our innovative research and services! #SfN2023 #Neuroscience #Research #ipsc #MEA #painresearch #drugdiscovery #Innovation #lifeatnsa

A factor involved in brain expansion in humans identified! The neocortex is the characteristic folded outer layer of the brain that resembles a walnut. It is responsible for higher cognitive functions such as abstract thinking, art, and language. The molecular mechanisms driving neocortex evolution are still largely unknown. Using 3D brain organoids, the group was able to show that a growth factor, known as epiregulin, indeed promotes the division and expansion of stem cells in the developing brain. Comparing the effect of epiregulin in human and gorilla brain organoids, the team found that adding epiregulin to gorilla brain organoids can further promote the expansion of stem cells. However, adding even more epiregulin to human brain organoids did not have the same effect. This might be because the human neocortex has already expanded to a very large extent. #ScienceMission #sciencenewshighlights https://lnkd.in/gaGhx3NC

#Microscopy monday! In the lab, we use human neural progenitor cells to study the dynamics of neural differentiation. In this image, two microtubule-associated proteins are imaged in tandem. Doublecortin (DCX) in green and Map-2 in red. We use these proteins as they are generally expressed in neurons along their differentiation axis. Early neuroblasts are more motile as they have to migrate and "find" their place in the brain. In this case DCX is more expressed as it is really good at stabilising the microtubules associated with cell polarisation and migration. (https://lnkd.in/dDPAqkKw). Now, more mature neurons, have their place established and need to work on developing their connections. For this, they have to send their axons for long distances until they find a strong synapse. Associated with this maturation process is the increased presence of Map-2 proteins that are needed to stabilise their microtubules as well as interact with neurofilaments. (https://lnkd.in/dTacs82D). Note how the green stained (DCX ) neurons have smaller processes while the red ones (MAP-2 ) have much longer processes. In the ReNEU lab at ICVS - Life and Health Sciences Research Institute Escola de Medicina - Universidade do Minho, we have applied this in-vitro paradigm to probe how secretome from stem cells as well as biomaterials alter such differentiation trajectories. Check out our publications: https://lnkd.in/dBnPh2qJ https://lnkd.in/drPB4qui https://lnkd.in/dX9KYpvM https://lnkd.in/dRPs56eX #cellbiology #stemcells #neuroscience #secretome

Sharing our latest application note on the use of animal origin-free BDNF and GDNF for neural stem cell differentiation. Discover how these growth factors can be a game-changer for your neural stem cell research. You will find: 🔹Detailed protocols 🔹Cutting-edge methodologies 🔹Expert insights on optimizing your experiments If you're advancing your research or exploring new avenues in neural stem cell differentiation, download the full application note here: https://zurl.co/0B2a Learn more about Qkine BDNF here: https://zurl.co/q4v0 and Qkine GDNF here: https://zurl.co/MYOR #Neuroscience #StemCells #BDNF #GDNF #Research #ScienceInnovation

It's an exciting and motivating time in the neuroscience community, and many of the highlights in the past month are a result of the latest developments in artificial intelligence. Cells (in the brain, and more generally) are key to understanding disease, and yet our knowledge of how they work and interact is limited. For example, we don't yet know how many types of cells actually exist in the human brain. Here are some amazing recent updates: 🧠 Today 21 papers, across 3 journals, were published revealing large-scale whole-brain cell atlases. This marks one of the greatest scientific developments in recent history (!) and amounts to a new field of study with entirely new deep parts of the brain being revealed | https://lnkd.in/e4MeM3MX 🧠 The Chan Zuckerberg Initiative's data contributions to the first "virtual cell" continue with the ongoing development of a high-performance computing cluster with 1000 H100 GPUs that facilitate new AI models trained on cell and biomolecule mass datasets | https://lnkd.in/eQWj2t2n 🧠 Embryonic stem cell research has been happening for decades (controversially, and at the cost of billions of dollars), and there still isn't an approved medical treatment. However, implants of lab-made neurons introduced into the brains of 12 people with Parkinson’s disease appear to be safe and may have demonstrated regenerative properties by reducing symptoms | https://lnkd.in/eavpQkhM. 🧠 "Embodiment" is the concept that organisms process sensory information in the context of a moving body, interacting with the environment (i.e., not in isolation). This is important in neuroscience, robotics, and artificial intelligence, and there has long been an assumption that this is consistent between species. New research challenges this by using more comprehensive ML and AI modelling | https://lnkd.in/e5ab66Jh #neuroscience #technology #MITtechnology #artificialintelligence #AI #CZI #Nature

#TechTide Music is an emotion & #ArtificialIntelligence has progressed to the extent of deciphering this emotion by analyzing brainwave patterns in individuals suffering from neurological conditions. AI is now reading what's inside Universe's most complex structure, Human Brain NIMHANS: Leading the Way for Mental Health and Neuro Sciences University of California, Berkeley National Brain Research Centre Institute for Stem Cell Science and Regenerative Medicine (DBT-inStem)

The brain is highly heterogeneous, comprised of many different cell types and intricate relationships. Spatial context of major cell lineages in human and mouse neural tissue helps us better understand primary brain cell constituents, such as microglia, astrocytes, neurons, endothelial cells, and oligodendrocytes, and distinguish infiltrating and resident myeloid and lymphoid immune cells. Application of Imaging Mass Cytometry™ for neuro phenotyping enables the high specificity and signal intensity needed with the absence of autofluorescence artifacts to successfully determine the spatial landscape of normal and neoplastic brain tissues. Stay tuned for our new imaging innovations to further enhance the quality of research that can be accomplished and improve our day-to-day experiences: https://lnkd.in/gqmehHnJ #tissueimaging #spatialbiology #cellphenotyping #neuroscience Highest Quality Information | Highest Throughput

The brain is highly heterogeneous, comprised of many different cell types and intricate relationships. The spatial context of major cell lineages in human and mouse neural tissue helps us better understand primary brain cell constituents, such as microglia, astrocytes, neurons, endothelial cells, and oligodendrocytes, and distinguish infiltrating and resident myeloid and lymphoid immune cells. Application of Imaging Mass Cytometry™ for neuro phenotyping enables the high specificity and signal intensity needed with the absence of autofluorescence artifacts to successfully determine the spatial landscape of normal and neoplastic brain tissues. Stay tuned for our new imaging innovations to further enhance the quality of research that can be accomplished and improve our day-to-day experiences: https://lnkd.in/gqmehHnJ #tissueimaging #spatialbiology #cellphenotyping #neuroscience Highest Quality Information | Highest Throughput

🧠✨ The first cellular map of a mammalian brain has been unveiled! A groundbreaking set of 10 papers in Nature showcases an atlas meticulously cataloging the location and type of every cell in the adult mouse brain. 🐭🗺️ With over 6 years of dedicated research and a staggering 32 million cells examined, this project reveals the astonishing diversity and regional specificity within the brain. 🔹 Dive Deeper: https://lnkd.in/gJKBFgpc 🔹 Explore the Papers: https://lnkd.in/g2aiVR5a This remarkable research, supported by The National Institutes of Health, is part of the BRAIN Initiative Cell Census Network (BICCN). 🧪🧬 The mission of #BICCN is to provide a comprehensive reference of diverse cell types in the human, mouse, and non-human primate brain. 🌐 How does this impact your research? Imagine having access to such detailed insights for your own studies! 🤯 Elevate your experiments with cutting-edge technology. Our company proudly distributes the extraordinary Merscope by Vizgen, the state-of-the-art instrument that played a pivotal role in this groundbreaking research, exclusively in Switzerland! 🇨🇭✨ 🔹 Curious to redefine your research capabilities? Merscope by Vizgen isn't just a tool; it's the key to unlocking the secrets of cellular diversity and regional specificity. Connect with us to discover how Merscope can transform your scientific journey, empowering you to explore the uncharted realms of life sciences and biotech! #bucherbiotec #lifesciences #research #Switzerland 🇨🇭 #BICCN #studyBRAIN #innovation #technology #biotech #scientificmarvel #neuroscience #cellmapping #Merscope #Vizgen #groundbreakingresearch #scientificadvancements #NaturePapers #researchtools #scientificcommunity