MaxWell Biosystems’ Post

It was a pleasure to moderate the Selected talks by PhD students and postdocs at the Nordic Neuroscience Meeting 2024 Brilliant presentation from our up and coming scientific young minds: Ruixin Tao, University of Copenhagen, Denmark. Title: APOE4 is instrumental in augmenting RhoA activation and contributes thereby to Alzheimer’s disease'. Maria Hanna Gotkiewicz, University of Eastern Finland, Finland. Title: 3D microscopy unravels details in amyloid plaque-microglia interaction in APP/PS1 mice. Christiana Bjorkli, NTNU, Norway. Title: Manipulation of neuronal activity in the entorhinal-hippocampal circuit affects intraneuronal amyloid-β levels. Tekla Kylkilahti, Lund University, Sweden. Title: Cerebrospinal fluid pathways are perturbed in prodromal Alzheimer’s disease. #neuroscience #alzheimers #ipscs #amyloid

I am looking forward to hearing about exiting scientific findings and discussing how MaxWell next generation electrophysiology platform can accelerate your recearch!!!

Have you seen 👀 it yet? The New CosMx SMI Mouse Brain FFPE dataset 🐭🧠. Uncover the mysteries of the mouse brain with CosMx SMI and take the Leap to Single-cell Spatial! https://bit.ly/3qdYaSt View the morphology stain of a half mouse brain, then🔍 zoom in to explore the spatially resolved transcript locations of mRNA targets overlaid with the morphology stain. This fades to a spatially resolved transcript location of mRNA targets overlaid with Cell Type results, which is then enlarged to a region of interest with Cell Type results overlaid with transcripts. #Neuroscience #MouseBrain #singlecellimaging 

More about #Neuroscience: Class 5 Photonics was on the biggest topical conference in Europe. Multi-photon imaging with our White Dwarf femtosecond lasers is growing💪 by the way, also beyond brain imaging: #oncology and #immunology are becoming new hot topics for the most advanced microscopy methods.

Did you know? Dheeraj Roy, PhD, assistant professor in the Department of Physiology and Biophysics at the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, is a senior author on a paper that explains aspects of how memory works at the cellular level. The researchers’ findings on the brain, published in Nature Neuroscience, could potentially lead to treatments for Alzheimer’s disease and other memory disorders. » Read the full article: https://buff.ly/47ZIAJO #UBuffalo #Alzheimers #MemoryDisorders #Neuroscience

Reminder: The February 1st deadline for #ASNM2024 Annual Conference abstract submissions is fast approaching! Don't miss the chance to present your #IONM work, earn CMEs/CEUs, and enjoy a discount on conference registration. ASNM members can submit up to two abstracts. Whether it's original research, a unique case study, or a literature review, we welcome your contributions. Follow our guidelines for a successful submission and be a part of an enriching platform or E-poster presentation. Submit now: https://lnkd.in/geZqP6Kd #Neurophysiology #neuroscience

🧠 Explore the fascinating world of brain organoids with The Scientist's upcoming webinar on February 20, 2024! Join experts Sofie Salama and Alysson Muotri as they unravel the mysteries of human brain development and evolution using these remarkable models. 🔬 Discover how stem cell-derived brain organoids are revolutionizing research in neurodevelopment and behavior. Learn about the techniques that allow scientists to mimic human neurodevelopment and study complex diseases in a lab setting. 🛠️Discover the applications of brain organoids in biomedical sciences and bioengineering. 🗓️ Don't miss out on this opportunity to expand your knowledge on one of the most innovative tools in neuroscience. Register now: https://ow.ly/MitE50QxIxp #organoids #neurodevelopment #stemcells #neuroscience #lifescienceresearch #sciencethursday

🤔 How can neurons predict your movement using both past and future input? 🧠 This new publication from the Buzsaki Lab, using our Janus Double-sided Probe, dives into hippocampal neurons' spatial tuning properties and memory functions. But are these distinct features or part of a dynamic continuum? Recent findings suggest that the "splitter" feature, which distinguishes different types of information processing, exhibits variation across trials and spatial positions. Typical place fields within the same neuron can split into subfields based on behavioral choices, with firing patterns evolving independently. Comparing tasks with and without delays, they found differences in neuronal computation, impacting route execution in maze tasks. The fraction of future-choice-predicting neurons rapidly decreases after reward consumption, affecting decision-making. Splitter features extend beyond hippocampal neurons, found in other brain regions like the entorhinal and prefrontal cortex. Optogenetic experiments suggest the entorhinal cortex's role in selecting future paths. Interneurons, influenced by pyramidal cell partners, show biased firing control, with those having fewer partners exhibiting higher selectivity. This highlights the intricate interplay between neuronal populations across different environments. Their findings shed light on the dynamic nature of hippocampal computation and its implications for memory and decision-making. Full study: https://hubs.ly/Q02mC57c0 #DBCInside #Neuroscience #Electrophysiology

The complexity and specificity of the developing brain is extraordinary ✔