For the first time in Ireland, Mark Cunningham FutureNeuro-funded investigator will conduct live human brain tissue studies from patients with refractory epilepsy. https://lnkd.in/e7ftPW6v
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CCDC88C variants are associated with focal epilepsy and genotype–phenotype correlation. Two de novo and two biallelic CCDC88C variants were identified in four cases with focal (partial) epilepsy. Patients with de novo variants presented with adult-onset epilepsy, whereas patients with biallelic variants displayed infant-onset epilepsy. CCDC88C variants associated with congenital hydrocephalus were all truncated, whereas epilepsy-associated variants were mainly missense. https://lnkd.in/dMpXb5eN
CCDC88C variants are associated with focal epilepsy and genotype–phenotype correlation
onlinelibrary.wiley.com
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Lesion-related epilepsy maps to a human brain network which could help identify patients at risk for epilepsy after a brain lesion and guide brain stimulation therapies. https://ja.ma/3RePia8
Mapping Lesion-Related Epilepsy to a Human Brain Network
jamanetwork.com
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Transcranial magnetic stimulation (TMS) acts on the cerebral cortex through a time-varying magnetic field to generate inductive currents and affect the electrical activity of cells, thereby exerting a neuromodulation effect. As a non-invasive diagnosis and treatment method, TMS has attracted the attention of clinicians and researchers, and is increasingly used in epilepsy-related basic research and clinical diagnosis and treatment, and has an encouraging application prospect. Therefore, TMS is a potential epilepsy diagnosis and treatment method, which is worthy of further exploration. ELITEMED TMS series products are very mature and have been used in many hospitals & clinics. Suitable for the auxiliary treatment of ischemic cerebrovascular disease, neuropathy (anxiety, neurasthenia, insomnia, brain fatigue and other symptoms), and brain injury diseases. #tms2023 #tms #epilepsy #cerebrovascular disease #neuropathy #brain injury #elite #elitemed
Clinical observation of transcranial magnetic stimulation in the treatment of epilepsy
elitemedtech.com
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#epilepsy #photobiomodulation #neuroprotection Lights for epilepsy: can photobiomodulation reduce seizures and offer neuroprotection? https://lnkd.in/gvwa2MKU Université Grenoble Alpes Epilepsy is synonymous with individuals suffering repeated “fits” or seizures. The seizures are triggered by bursts of abnormal neuronal activity, across either the cerebral cortex and/or the hippocampus. In addition, the seizure sites are characterized by considerable neuronal death. Although the factors that generate this abnormal activity and death are not entirely clear, recent evidence indicates that mitochondrial dysfunction plays a central role. Current treatment options include drug therapy, which aims to suppress the abnormal neuronal activity, or surgical intervention, which involves the removal of the brain region generating the seizure activity. However, ~30% of patients are unresponsive to the drugs, while the surgery option is invasive and has a morbidity risk. Hence, there is a need for the development of an effective non-pharmacological and non-invasive treatment for this disorder, one that has few side effects. In this review, we consider the effectiveness of a potential new treatment for epilepsy, known as photobiomodulation, the use of red to near-infrared light on body tissues. Recent studies in animal models have shown that photobiomodulation reduces seizure-like activity and improves neuronal survival. Further, it has an excellent safety record, with little or no evidence of side effects, and it is non-invasive. Taken all together, this treatment appears to be an ideal treatment option for patients suffering from epilepsy, which is certainly worthy of further consideration.
Lights for epilepsy: can photobiomodulation reduce seizures ... : Neural Regeneration Research
journals.lww.com
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First Child Brain Implant for Epilepsy Appears Successful A groundbreaking implantable device has significantly reduced the frequency and severity of seizures in children with severe epilepsy, according to a new UK clinical trial. The rechargeable device, attached to the skull, delivers constant electrical stimulation to the brain, allowing patients like Oran to experience dramatic improvements in quality of life. This trial, known as the CADET pilot, is the first to measure this treatment for pediatric epilepsy and shows promise for broader applications. Further research will expand to more patients, aiming for a new standard in epilepsy treatment. 𝗦𝗵𝗮𝗿𝗲 𝗶𝗳 𝘆𝗼𝘂 𝗳𝗼𝘂𝗻𝗱 𝘁𝗵𝗶𝘀 𝘃𝗮𝗹𝘂𝗮𝗯𝗹𝗲!
First Child Brain Implant for Epilepsy Appears Successful
https://neurosciencenews.com
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#epilepsy #microRNA #experimentalmodel #therapeutictarget MicroRNAs in mouse and rat models of experimental epilepsy and potential therapeutic targets https://lnkd.in/dRPM8ekd University of Otago Epilepsy is a common and serious neurological disease that causes recurrent seizures. The brain damage caused by seizures can lead to depression, anxiety, cognitive impairment, or disability. In almost all cases chronic seizures are difficult to cure. MicroRNAs are widely expressed in the central nervous system and play important roles in the pathogenesis of several neurological disorders, including epilepsy. A variety of animals (mostly mice and rats) have been used to induce experimental epilepsy using different protocols and miRNA profiling performed. Most of the recent studies reviewed had performed miRNA profiling in hippocampal tissues and a large number of microRNAs were dysregulated when compared to controls...
MicroRNAs in mouse and rat models of experimental epilepsy... : Neural Regeneration Research
journals.lww.com
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In my previous post I touched upon this very interesting article, here I will provide more details about the significance of the findings: Frontier NeuroSci: 2022 Aug 17 "Continuous theta burst stimulation for drug-resistant epilepsy" 🔍 **Key Insights from the Study:** The study delves into the safety and efficacy of Continuous Theta Burst Stimulation (cTBS) for drug-resistant epilepsy (DRE). As a Board Certified Neurologist and TMS Specialist, I'm thrilled to present key findings that could reshape the landscape of epilepsy treatment. 🚀 **Navigating Safety Horizons: Unprecedented Findings in TBS** The study pioneers an intensified cTBS protocol for epilepsy patients, highlighting the commitment to innovation in neurostimulation. Importantly, all participants completed the study without any serious adverse events. ⚖️ **Balancing Act: Managing Adverse Events Safely** Patients experienced local sensations and headaches during stimulation, with caution warranted for potential unintended co-stimulation of adjacent brain regions. 🌐 **Extending Frontiers: TBS in Epileptic Population** Experience with cTBS in epilepsy patients is limited, and caution remains essential in a seizure-prone population. The study, a pioneer in this field, reported no induced seizures during cTBS sessions. The exploration of TBS in epilepsy, considering its safety and tolerability, opens new avenues for personalized treatment strategies. 🌟 **Beyond Seizure Reduction: Cognitive and Emotional Impact** Assessment of cognitive and psychological aspects revealed promising outcomes. There was a trend towards improved cognitive function, and the study did not identify a negative impact on psycho-emotional well-being. Subject-reported improvements in quality of life and anxiety traits suggest the potential holistic benefits of cTBS. 👩⚕️ **Feasibility and Future Directions:** The study demonstrates the feasibility of cTBS as an anti-epileptic treatment, with participants expressing a willingness to repeat the treatment for long-term seizure suppression. While this pilot study provides encouraging results, a larger, randomized controlled trial is needed to reliably identify therapeutic effects and optimize treatment parameters. 🌈 **Conclusion: Toward a New Frontier in Epilepsy Care** This study lays the foundation for exploring cTBS as a transformative treatment for drug-resistant epilepsy. The safety, feasibility, and potential anti-epileptic effects suggest a promising future for cTBS, offering hope to patients and clinicians alike. Let's continue pushing the boundaries of innovation in epilepsy care together! #EpilepsyResearch #NeurologyInnovation #TMSAdvancements #MedicalBreakthrough #EpilepsyAwareness #ContinuousThetaBurstStimulation #SeizureTreatment #NeurologicalAdvancements #countrysideneurology
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With the strides made in epilepsy treatment over recent decades, it's crucial to acknowledge that a significant number of patients still grapple with seizures resistant to existing medical and surgical therapies. However, the dawn of potential breakthroughs is upon us, holding promise for personalized medicine, enhanced health and improved quality of life. Researchers are developing innovative treatments and are delving into complementary approaches to augment conventional medical regimens. Neurofeedback—a form of biofeedback therapy centered around patient-driven modulation of the electroencephalogram (EEG) – is gaining traction. The core principle behind neurofeedback involves the synchronization of specific EEG frequencies, believed to exert an influence over both seizure control and behavioral aspects. Neurofeedback harnesses the power of behavioral conditioning, empowering patients to actively engage in their own well-being. By providing positive reinforcement for producing specific EEG frequencies, individuals are motivated to actively engage in their treatment process. When patients successfully create the desired brainwave patterns, they receive rewards or incentives. Active participation empowers them to play a hands-on role and engage with their own healing journey, fostering a sense of control and collaboration in managing their condition. Collaborations between medical professionals, researchers, and patients will be pivotal in shaping the potential impact of integrating neurofeedback into the epilepsy treatment landscape. This innovative strategy enhances the lives of those who continue to seek effective solutions against the challenges of epilepsy. #EpilepsyResearch #Neurofeedback #InnovationInHealthcare #CollaborativeApproach https://lnkd.in/e4t_PrbJ
PII: S1525-5050(02)00001-X
neurofeedbackclinic.ca
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Professor of Pharmacognosy, Natural Products Chemistry and Food Chemistry, Pharmacognosy Department, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt
First Child Brain Implant for Epilepsy Appears Successful https://lnkd.in/dMCMCp57
First Child Brain Implant for Epilepsy Appears Successful - Neuroscience News
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Functional connectomic profile correlates with effective anterior thalamic stimulation for refractory epilepsy
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brainstimjrnl.com
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