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PATIENTS ON LONGTERM OPIOIDS OFTEN “IRRATIONAL.” (Seriously?) #America #JAMA #mentalcapacity #primarypain #secondarypain #noonesizefitsall #enforcedtapering #patientcentredcare #opioidprescribingguidelines #opioidreview #dontpunishpain #opioidhysteria #advocacy #opioidrestrictions #opioidcrisis #opioidepidemic #opioidhysteria #chronicpain #humanrights #chronicpainpatients #prescriptionopioids #deprescribingopioids #abandonment #untreatedpain #addiction #dependence #opioidusedisorder #substanceabuse #overdose #multidisciplinary #painmanagement #education #stopthestigma #holisticcare #qualityoflife #shareddecisionmaking

Prescription opioids used for pain relief are generally safe when taken for a short time and as prescribed by a doctor, but they can be misused. People misuse prescription opioids by: 1️⃣ taking the medicine in a way or dose other than prescribed. 2️⃣ taking someone else's prescription medicine. 3️⃣ taking the medicine for the effect it causes-to get high. ⚠️ When misusing an opioid prescription, a person can swallow the medicine in its normal form. Sometimes people crush pills or open capsules, dissolve the powder in water, and inject the liquid into a vein. Some also snort the powder. ✅️ In the short term, opioids can relieve pain and make people feel relaxed and happy. However, opioids can also have harmful effects, including: ✔️drowsiness ✔️confusion ✔️nausea ✔️constipation ✔️euphoria ✔️slowed breathing ⚠️ Opioid misuse can cause slowed breathing, which can cause hypoxia. ⚠️ Hypoxia can have short- and long-term psychological and neurological effects, including coma, permanent brain damage, or death. ✅️ Older adults are at higher risk of accidental misuse or abuse because they typically have multiple prescriptions and chronic diseases, increasing the risk of drug-drug and drug-disease interactions, as well as a slowed metabolism that affects the breakdown of drugs. ⚠️ If a woman uses prescription opioids when she's pregnant, the baby could develop dependence and have withdrawal symptoms after birth. Use during pregnancy can also lead to miscarriage and low birth weight. ✅️ Medications for opioid use disorders are safe, effective, and save lives. These medicines interact with the same opioid receptors in the brain on which other prescription opioids act. 1️⃣ Methadone, an opioid receptor full agonist, attaches to and activates opioid receptors to ease withdrawal symptoms and cravings. 2️⃣ Buprenorphine, an opioid receptor partial agonist, attaches to and partially activates opioid receptors to ease withdrawal symptoms and cravings. 3️⃣ Naltrexone, an opioid receptor antagonist, prevents opioids from attaching to opioid receptors, thus blocking their effects. ✅️ Behavioral therapies such as cognitive behavioral therapy helps modify the patient's drug use expectations, and also effectively manage triggers and stress. ✅️ Multidimensional family therapy, developed for adolescents with drug use problems, addresses a range of personal and family influences on one's drug use patterns and is designed to improve overall functioning. ⬆️ These behavioral treatment approaches have proven effective, especially when used along with medicines.

Prescription opioids used for pain relief are generally safe when taken for a short time and as prescribed by a doctor, but they can be misused. People misuse prescription opioids by: 1️⃣ taking the medicine in a way or dose other than prescribed. 2️⃣ taking someone else's prescription medicine. 3️⃣ taking the medicine for the effect it causes-to get high. ⚠️ When misusing an opioid prescription, a person can swallow the medicine in its normal form. Sometimes people crush pills or open capsules, dissolve the powder in water, and inject the liquid into a vein. Some also snort the powder. ✅️ In the short term, opioids can relieve pain and make people feel relaxed and happy. However, opioids can also have harmful effects, including: ✔️drowsiness ✔️confusion ✔️nausea ✔️constipation ✔️euphoria ✔️slowed breathing ⚠️ Opioid misuse can cause slowed breathing, which can cause hypoxia. ⚠️ Hypoxia can have short- and long-term psychological and neurological effects, including coma, permanent brain damage, or death. ✅️ Older adults are at higher risk of accidental misuse or abuse because they typically have multiple prescriptions and chronic diseases, increasing the risk of drug-drug and drug-disease interactions, as well as a slowed metabolism that affects the breakdown of drugs. ⚠️ If a woman uses prescription opioids when she's pregnant, the baby could develop dependence and have withdrawal symptoms after birth. Use during pregnancy can also lead to miscarriage and low birth weight. ✅️ Medications for opioid use disorders are safe, effective, and save lives. These medicines interact with the same opioid receptors in the brain on which other prescription opioids act. 1️⃣ Methadone, an opioid receptor full agonist, attaches to and activates opioid receptors to ease withdrawal symptoms and cravings. 2️⃣ Buprenorphine, an opioid receptor partial agonist, attaches to and partially activates opioid receptors to ease withdrawal symptoms and cravings. 3️⃣ Naltrexone, an opioid receptor antagonist, prevents opioids from attaching to opioid receptors, thus blocking their effects. ✅️ Behavioral therapies such as cognitive behavioral therapy helps modify the patient's drug use expectations, and also effectively manage triggers and stress. ✅️ Multidimensional family therapy, developed for adolescents with drug use problems, addresses a range of personal and family influences on one's drug use patterns and is designed to improve overall functioning. ⬆️ These behavioral treatment approaches have proven effective, especially when used along with medicines.

CNN HEALTH-weekly newsly-Patients with chronic pain tout the benefits of ketamine, but doctors still aren’t sure how it works Recent headlines about ketamine have been connected to the death of actor Matthew Perry, whose autopsy showed that he died of “acute effects” of the drug. This may be the first time some people have heard of the drug, but it has been used by doctors since the 1970s. Ketamine became widely used in field hospitals during the Vietnam War because it doesn’t depress breathing and heart rate the way some other kinds of anesthesia can. At the same time, it raises blood pressure and heart rate, which can be helpful for people who’ve lost blood. The US Food and Drug Administration has approved the drug for anesthesia and in 2019 approved a derivate of it known as esketamine for treatment-resistant depression. But there has been increasing off-label use of ketamine, including some hospitals and specialty pain clinics that are using infusions to treat intractable pain. “A lot of pain docs sort of think it’s sort of voodoo-ish, if you will, sort of like, ‘What are you really doing here?’ ” said Dr. Pavan Tankha, a pain specialist at the Cleveland Clinic who is treating people with the drug. Some people who have chronic pain say the relief they get after their treatments lasts months. Experts say it’s hard to understand how it could be working that long, and they point out that while preliminary evidence is promising, there’s just not a lot of high-quality research to help explain why it might work or who could see the most benefit. Adding a pet may offset a type of cognitive decline if you live alone over 50, study says People older than 50 who live alone may be able to counter decline in their verbal cognition by adding a pet to their home, according to a new study. Losing the ability to easily find words and understand others can be early signs of dementia, research has found. The study analyzed data from people 50 and older participating in the English Longitudinal Study of Ageing who lived with pets. The researchers analyzed answers to an abbreviated word test about animals that assessed the person’s ability to pay attention to the words, encode the words and recall them later. Pet ownership was associated with slower rates of decline in an overall score of verbal cognition, verbal memory and fluency if a person lived alone, but not if they lived with other people. But the reason for that is unclear, said study coauthor Dr. Ciyong Lu, professor of epidemiology and medical science and associate dean of the School of Public Health at Sun Yat-sen University in Guangzhou, China. “One caution I would say is that if a person who lives alone already has cognitive impairment or physical limitations such as balance or vision problems, it wouldn’t generally be advisable for that person to adopt a pet to slow down their brain aging,” he added.

TOPIC: One Lot of Clonazepam Orally Disintegrating Tablets, USP (C-IV) Lot Number 550147301 by Endo USA: Recall - Due to Mislabeling: Incorrect Strength on Product Carton AUDIENCE: Patient, Health Professional, Pharmacy, Neurology ISSUE: Endo USA is recalling one lot of Clonazepam Orally Disintegrating Tablets, USP (C-IV) 0.25 mg tablets, which may also appear as Clonazepam Orally Disintegrating Tablets, USP (C-IV) 0.125 tablets 60-count pack to the consumer level. The product lot is being recalled due to mislabeling where an incorrect strength appears on the cartons of some packs to show the product strength as 0.125 mg and not 0.25 mg due to an error at a third-party packager. The blister strips inside the product pack reflect the correct strength of 0.25 mg. Risk Statement: Children and adults who are inadvertently prescribed a two-fold overdose of clonazepam would be at risk for the adverse effects of significant sedation, dizziness, ataxia, and confusion. There is reasonable probability for significant, possibly life-threatening, respiratory depression especially for patients with concomitant pulmonary disease, patients who have prescribed dosing near maximal dosing, and patients also taking other medications that could cause additional respiratory depression. To date, Endo has not received any reports of adverse events associated with this product lot recall. The product lot was distributed through wholesale distributors to retail pharmacies nationwide. For more information about this recall, click on the red button "Read Recall" below. BACKGROUND: Clonazepam Orally Disintegrating Tablets are indicated alone for as an adjunct in the treatment of the Lennoz-Gastaut syndrome (petit mal variant), akinetic and myoclonic seizures. Additionally, the product is indicated for the treatment of panic disorder. RECOMMENDATIONS: Distributors, retailers that have the product lot being recalled should immediately stop distributing and dispensing and return to the place of purchase or contact Inmar on the below telephone line. Consumers in possession of any unused prescribed 60 tablet cartons of Clonazepam Orally Disintegrating Tablets, USP 0.25 mg which may also appear as Clonazepam Orally Disintegrating Tablets USP 0.125 mg bearing the lot number 550147301 have been advised to discontinue use of the product. In the event that a patient inadvertently took a 0.25 mg dose rather than the intended 0.125 mg dose, they are advised to consult a physician. Consumers with questions regarding this recall can contact Inmar by telephone at 877-890- 0765 or by email at [email protected]. Health professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:

A definitive study of suicides following prescription opioid dose reductions among patients in chronic pain. To follow up on this announcement may contact Dr Stefan Kertesz, the principle investigator, at [email protected] The following is from the one-sheet summary of the study as approved by the Veterans Administration: CSI:OPIOIDs – a Research Study Summary for General Public and Potential Participants Let’s prevent suicides that happen after prescription opioid reduction or stoppage. Principal Investigator: Stefan G. Kertesz, MD, MSc (Heersink UAB School of Medicine & Birmingham Alabama VA Healthcare System) Co-investigators/Consultants shown: Thomas Joiner (FSU), Allyson Varley (UAB), Adam J. Gordon (University of Utah), Meghan McCullough (UMass & Bedford VA) Stephanie Gamble (VA Canandaigua), Anne Fuqua (UAB), Kevin Riggs (UAB), Mark Flower, Joshua Richman (UAB), April Hoge (Birmingham VA), Dawn Gibson Funder: US Department of Veterans Affairs, Health Services Research and Development Branch General Information Website: CSI:OPIOIDs (Research to Understand and Prevent Loss of Life After Medication Dose Reduction in Pain) Sites: Birmingham, Alabama VA Health Care System, Edith Nourse Rogers Veterans Affairs Medical Center, VA Salt Lake City Health Care System CSI:OPIOIDs (Clinical Context of Suicide Following Opioid Transitions) is a scientific research study to closely examine suicides that have occurred after prescription opioid dose reductions in patients with long-term pain. The team will look at 110-120 suicides, split between those among individuals who were Veterans of the US armed forces and people who were not Veterans. Although these suicides are not common, research based on large databases does find a consistent association between opioid reduction and increased incidence of suicidal events. Members of our research team have seen many reports of these suicides or have been personally connected to individual deaths by suicide. ========== This is needed work that I personally endorse. The CSI:OPIOIDs team will: • Compile a registry of people who have died by suicide following a reduction or stoppage in their opioid medication. • Perform in-depth, one on one interviews with survivors of individuals who have died by suicide after opioid transition to understand what led their loved-one to die by suicide, and review medical records when they are obtainable. • Identify factors common to these individuals prior to their death and suggest ways to reduce likelihood that future patients will die by suicide under similar circumstances. The approach used in this study, psychological autopsy, offers descriptive portrait of each death. The resulting insights will help health systems, policy makers, and prescribers make better decisions to prevent these tragedies. There is a website for the general public and a separate one for persons who wish to enter the study. Please feel free to pass on this announcement.

What to know about tinnitus and blood pressure drugs Tinnitus and its Connection to Blood Pressure Medications Hypertension, a prevalent medical condition characterized by elevated blood pressure levels, poses a significant health concern affecting millions worldwide. If left unmanaged, it can lead to severe health complications, including kidney dysfunction, heart diseases, and strokes. To combat high blood pressure, physicians often prescribe medications aimed at reducing these elevated levels. However, some individuals may experience an unexpected side effect while taking these medications - a persistent ringing in the ears, known as tinnitus. In this comprehensive exploration, we delve into the question of whether high blood pressure medication can indeed trigger tinnitus. Dr. Ben, an esteemed audiologist and tinnitus specialist based in California, offers invaluable insights into this matter. He asserts that high blood pressure medication, per se, doesn't directly cause tinnitus. However, a specific class of medications known as loop diuretics, employed to increase urine production, can, under certain circumstances and in high doses, exhibit ototoxic properties. Ototoxicity refers to the potential harm inflicted upon the ear, which may manifest as tinnitus. Getting High Blood Pressure Under Control According to the American Heart Association, high blood pressure affects nearly half of all adults in the United States, representing a persistent force exerted by the blood against the walls of blood vessels. The standard blood pressure target is less than 120 mmHg for systolic pressure (the upper number) and less than 80 mmHg for diastolic pressure (the lower number). Without effective management, high blood pressure can lead to grave health issues, including kidney impairment, vision deterioration, strokes, and heart attacks. While lifestyle modifications can offer some relief, managing high blood pressure often necessitates the use of prescription drugs, which may entail certain side effects. Though the precise reasons for some blood pressure medications being more likely to induce tinnitus remain unclear, it is postulated that the reduction in cochlear blood flow, attributed to medication-induced blood pressure reduction, might contribute to the occurrence of tinnitus. Read more here: https://lnkd.in/eqHne7r7

🤯 I am thankful not to be prescribed another horrible questionable 🤨 FDA medication for anything. You can grow your own medicine. It’s safer apparently much safer. Of course this is my opinion only and if it’s not prescribed here, why is there an issue in Florida with this substance? Tianeptine is prescribed for depression treatment in some countries outside the United States. Here's how it is typically used: - **Dosage**: Tianeptine is usually prescribed at low doses for its antidepressant effects. The exact dosage can vary based on the specific formulation and the patient's condition². - **Administration**: It is often administered orally, in the form of tablets or capsules². - **Mechanism of Action**: Tianeptine works by modulating brain chemicals, including serotonin, which can affect mood³. It is believed to enhance serotonin uptake in the brain, which differs from the mechanism of most common antidepressants that inhibit serotonin reuptake⁴. - **Efficacy**: Studies have shown that tianeptine is effective against serious depressive episodes, comparable to other antidepressants like amitriptyline, imipramine, and fluoxetine, but with significantly fewer side effects⁴. - **Additional Benefits**: It has also been reported to be more effective than maprotiline in patients with co-existing depression and anxiety⁴. It's important to note that while tianeptine is used as a prescription drug for depression in some European, Asian, and Latin American countries, it is not approved for use in the U.S. due to concerns about its safety and potential for misuse². The FDA has placed tianeptine on its Advisory List of ingredients Source: Conversation with Bing, 4/11/2024 (1) TIANEPTINE - Uses, Side Effects, and More - WebMD. https://lnkd.in/gz3Yw8-t. (2) Tianeptine: Effects, Addiction Potential, and Withdrawal Symptoms. https://lnkd.in/gF33wNZs. (3) Tianeptine - Wikipedia. https://lnkd.in/g9Zmrxgj.