International Society of Blood Transfusion (ISBT)’s Post

🛑 When to pull out al(l) the Albumin stops? 💫 New guidelines from the International Collaboration for Transfusion Medicine provide updated recommendations on the use of intravenous (IV) albumin. 🥼🩺 Curbsider Dr. Jen DeSalvo summarizes the new guidelines in the latest version of The Digest! Give it a ❤️ and 🤝share it with someone who’d love to hear these guidelines!

Impact of Blood Products Transfusion on Patients in the Immediate Post-Lung #Transplant Period: A Cohort Study | https://ow.ly/H5Wg50Rr9or #lung #lungtransplant #transplantation #fridayreads #weekendreads

ABO blood groups explained with examples The discovery of the ABO blood group, over 100 years ago, caused great excitement. Until then, all blood had been assumed to be the same, and the often tragic consequences of blood transfusions were not understood. As our understanding of the ABO group grew, not only did the world of blood transfusion become a great deal safer, but scientists could now study one of the first human characteristics proven to be inherited. A person's ABO blood type was used by lawyers in paternity suits, by police in forensic science, and by anthropologists in the study of different populations. The ABO blood group antigens remain of prime importance in transfusion medicine they are the most immunogenic of all the blood group antigens. The most common cause of death from a blood transfusion is a clerical error in which an incompatible type of ABO blood is transfused. The ABO blood group antigens also appear to have been important throughout our evolution because the frequencies of different ABO blood types vary among different populations, suggesting that a particular blood type conferred a selection advantage (e.g., resistance against an infectious disease.) However, despite their obvious clinical importance, the physiological functions of ABO blood group antigens remain a mystery. People with the common blood type O express neither the A nor B antigen, and they are perfectly healthy. Numerous associations have been made between particular ABO phenotypes and an increased susceptibility to disease. For example, the ABO phenotype has been linked with stomach ulcers (more common in group O individuals) and gastric cancer (more common in group A individuals). Another observation is that individuals with blood type O tend to have lower levels of the von Willebrand Factor (vWF), which is a protein involved in blood clotting. Youtube video: https://lnkd.in/d9wycvxt #nikolaysgeneticslessons

New research in Canada sheds light on a concerning discovery regarding Hepatitis E virus (HEV) in cystic fibrosis patients, especially those who have undergone lung transplant. The study underscores the importance of understanding the potential risks associated with pancreatic enzyme replacement therapy (PERT) derived from pigs, a known HEV reservoir. This insightful article delves into the implications of zoonotic virus transmission through PERT, urging a closer look at patient safety practices. #HEV #CysticFibrosis

🎯 Trivia Question: Which of the following mechanisms is primarily targeted by immunotherapy for the treatment of autoimmune diseases to restore immune tolerance? A. Enhancing regulatory T cells (Tregs) function.   B. Depleting B-lymphocytes.   C. Blocking costimulatory signals for T-cell activation.   D. Inhibiting dendritic cell maturation. #Trivia #Immunotherapy #AutoimmuneDiseases #Medicine #Healthcare Sciqst, Precise References in Medicine. www.sciqst.com

🦠🔬 In the framework of the #VIRMOFProject, researchers of BMOFs - Advanced Porous Materials Unit have proposed a pioneering approach by studying nanoscale organometallic structures as safe therapeutic agents for the treatment of COVID-19. This research paves the way toward novel antiviral therapies based on nanoMOFs, not only against SARS-CoV-2 but also against other challenging infectious and/or pulmonary diseases. 🔗 Read the full article at ACS Publications: https://lnkd.in/eguDjAsU

Join us for a webinar featuring Prof. Tawesak Tanwandee, an esteemed expert in hepatology, as we discuss optimising care pathways for chronic hepatitis B.

One of our top ten articles this month: Efficacy and safety of restrictive versus liberal blood transfusion strategies in acute myocardial infarction and anemia: a #systematicreview and #metaanalysis of randomized controlled trials by Amin et al. https://lnkd.in/eYmJkNMv

A new consortium co-led by our researchers has been awarded a $31 million grant to accelerate the development of faster, more effective treatment regimens for tuberculosis (TB). The National Institutes of Health grant brings together more than 30 multidisciplinary researchers from 20 institutions in 6 countries to identify the most promising new and existing treatment combinations for TB and help advance them toward clinical trials. A lack of new drug development and lengthy existing treatment regimens have contributed to the persistence of TB worldwide despite the availability of curative antimicrobial therapies. https://bit.ly/3Lib5JZ