😃 😃 Congratulations on Prof Yuanyuan Li‘s newly published case report “Multiple ‘rings’ in the brain” on BMJ with IF 105.7! (doi: https://lnkd.in/gcSY7X5A) This case is from Xiangya Hospital, Central South University in which a 60s woman was diagnosed with K1 hypervirulent Klebsiella pneumoniae species (hvKP) using Hugobiotech’s mNGS pathogen diagnosis solution and was finally treated. It showed again that mNGS is an important novel way in pathogen detection and Hugobiotech is committed to transform the pathogenic diagnosis paradigm. #mNGS #pathogen #pathogenic #diagnosis #BMJ #infectious #casereport
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On this Rare Disease Day, 29 February, we stand in solidarity with the 300 million people worldwide battling rare diseases, along with their families and caregivers. At Constantiam Biosciences, we're committed to making a difference in their lives through innovation and research. Our platform, MAVEvidence, is at the forefront of this mission, providing crucial insights into the genetic basis of rare diseases. By empowering scientists and clinicians with precise, actionable data, we're helping to unlock new pathways for diagnosis, treatment, and ultimately, hope. Today, we reiterate our dedication to advancing the science of genetics, striving to bring light to those affected by rare diseases. Together, we can generate the change needed to improve lives and foster a future where no disease is too rare to care about. #rarediseaseday2024 #MAVEvidence #ConstantiamBiosciences #genetictesting
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We are excited to share that Ramon Garcia and Bill Gillespie from MetrumRG, alongside other industry scientists, have spearheaded novel research in systemic lupus erythematosus (SLE) treatment efficacy through a model-based meta-analysis (MBMA). Their latest study involved an in-depth analysis of numerous investigational agents and approved therapies in 25 studies comprising 81 treatment arms, evaluating 16 different agents. Leveraging a sophisticated Bayesian framework and latent variable models, this research compared treatment effects against placebos, setting a new benchmark for assessing efficacy in SLE treatments. This novel MBMA not only benchmarks the efficacy of these compounds but also showcases the application of latent variable models in understanding chronic disease trajectories. For further insights, explore the published article here: https://lnkd.in/gEmhH5X6 #CPTjournal #ASCPT #bayesian #MetrumRG
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Timely update ahead of #BIoEurope: We are making great progress with our PMD-OPTION study in Primary Mitochondrial Disease (PMD). The first patient has now entered the interventional part of the study and is receiving OMT-28 in once-daily doses. Meet us next week at the BioEurope Partnering Conference in Munich, to learn more about the study design and development strategy in PMD. The PMD-OPTION study starts with a 12-week untreated run-in phase, capturing each patients’ natural history and baseline parameters. Subsequently, the safety and tolerability of OMT-28 are evaluated, and the response rate of patients showing a reduction of Growth differentiation factor 15 (GDF-15) levels by at least 20% compared to the recorded baseline is reported. As an open label study, we anticipate providing interim data readouts in 2024 and completion of the study in 2025.
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🚀 Kick-off Meeting of ARTEMIs - The Power of Virtual Twins to Fight MAFLD Consortium We are thrilled to officially launch the European collaborative research project with representatives from all our 21 partner institutions today at the PariSanté Campus in Paris, France. Since January 1st, #ARTEMIs has been striving to lead the way towards #personalizedmedicine with #liver and #heart #VirtualTwins alongside a state-of-the-art Clinical Decision Support System (#CDSS). As we begin our work towards redefining the landscape of #MAFLD (Metabolic dysfunction-associated fatty liver disease) management, stay tuned for more highlights from today's event! #EuropeanResearch #HorizonEurope
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A brilliant talk from Catriona Crombie this morning at Beacon for Rare Diseases #RareShowcase23 highlighting the work LifeArc are doing, as part of our Rare Disease Translational Challenge, to tackle some of the major obstacles facing rare disease translational science. #LifeArc #translationalresearch #raredisease
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Co-founder & CBO @ Vincere Biosciences | Conquering Age-Related Decline with AI-Driven Drug Discovery
Could propagation of mitochondrial DNA be driving Parkinson's progression? Watch this presentation and Q&A for another interesting perspective in the evolving story around intercellular communication, mitochondrial damage, and disease.
This week we welcomed our guest presenter who is from a time zone six hours ahead - our first international Vincere weekly Journal Club guest! Københavns Universitet - University of Copenhagen Professor Shohreh Issazadeh-Navikas explains her recent publication describing how damaged mtDNA contributes to the progression of sporadic Parkinson’s disease. #journalclub #unicopenhagen #openscience #vincere #mitochondria #parkinsons #mtDNA https://lnkd.in/eHT3hSEZ
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Social Media Manager of ME and LONG COVID unite SA [MELCuSA] Millions Missing Voice Global and Millions Missing Voice.
An extensive review (https://bit.ly/4bro1rp) on ME/CFS from a multidisciplinary team, including researchers and clinicians, has recently been published. The paper focuses on “describing ME/CFS in terms of symptoms, severity and burden, diagnostic criteria, causes and triggers; followed by an overview of the complex pathophysiology and management of the condition.” Whilst not necessarily providing new information about ME/CFS, this review pools together information from multiple sources to provide a helpful overview of this complex disease. Read more: https://lnkd.in/d2g_uN-q #MyalgicEncephalomyelitis #MECFS #pwME #myalgicE
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If you missed our conference call last Friday on the positive interim analysis of the FALCON study, you can access the replay by following the link below: #mitochondrialdisease #raredisease #interimanalysis #clinicaltrials https://lnkd.in/dDiMCqDg
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If you missed the conference call Friday the 19th of July, following our positive interim analysis readout of the FALCON study, you can access the replay by following the link below
If you missed our conference call last Friday on the positive interim analysis of the FALCON study, you can access the replay by following the link below: #mitochondrialdisease #raredisease #interimanalysis #clinicaltrials https://lnkd.in/dDiMCqDg
Abliva Conference Call to Discuss the Positive Interim Analysis of the FALCON Study for KL1333 in Primary Mitochondrial Disease - LifeSci Events
https://lifescievents.com
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March 2024 marks The Journal of Critical Limb Ischemia's three-year anniversary! Journal of Critical Limb Ischemia is the only peer-reviewed journal dedicated to advancing the treatment of critical limb-threatening ischemia. The goal of the journal is to provide an international forum for the presentation of original ideas and recent results related to all aspects of diagnostic, therapeutic and pathophysiologic aspects of critical limb ischemia. Journal of Critical Limb Ischemia is the official journal of the CLI Global Society. JCLI is the first and only academic journal to focus on interventional techniques pertaining to the complex disease. Learn more >> clijournal.com #CLIFighters
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