Harmony Healthcare - Talent and Consulting Solutions’ Post

The Hexokinase 1 5′-UTR Mutation in Charcot–Marie–Tooth 4G Disease Alters Hexokinase 1 Binding to Voltage-Dependent Anion Channel-1 and Leads to Dysfunctional Mitochondrial Calcium Buffering

Small-Extracellular-Vesicle-Derived miRNA Profile Identifies miR-483-3p and miR-326 as Regulators in the Pathogenesis of Antiphospholipid Syndrome (APS)

In #NorthMacedonia 🇲🇰, #policymakers have an opportunity to raise #tobacco excise taxes & reap both fiscal and #publichealth benefits. 🆕 #research from Analytica assesses the impact of a 10%, 30%, and 50% increase in tobacco taxes. The findings demonstrate that each of these scenarios would raise additional #tax revenue for the government 📈 & reduce premature tobacco-related deaths 📉 by: - prompting current #smokers to quit or reduce their smoking intensity & - discouraging youth from initiating #smoking in the first place. Learn more about this evidence & the #policy implications 👇 https://lnkd.in/ghB6jXqn

Due to its small particle size, high specific surface area, functional capability and long-term stable fluorescence, nanodiamond (ND) has been widely used in biomedical applications including fluorescent probes, drug delivery and biological imaging. Nevertheless, the metabolism of ND and its derivatives is not yet well understood for diverse biomedical applications. In this study, to evaluate the cytotoxicity and biodistribution of the ND derivative, pure ND was functionalized with ethylenediamine (EDA) as a linker (ND-EDA) and then covalently labeled with an organic fluorescent dye called calcein. The modified ND is referred to as ND-EDA-calcein. Even at the maximum dose of 0.1 mg·mL−1, the in vitro results for ND-EDA-calcein against HepG2 and LO2 cell lines showed negligible cytotoxicity, which was in line with the in vivo observations. In addition, it was found that following an intraperitoneal injection, ND-EDA-calcein could be accumulated mostly in the liver and kidney of the mice but not in the spleen. It is interesting to note that after 5 days following intraperitoneal injection, mice can totally metabolize the elimination of ND-EDA-calcein outside of their bodies. Therefore, our findings suggested that NDs can be considered for various nanomedicine applications including drug delivery and biomarkers.

Practically all diagnostic tests carry the risk of false positives, which can render results effectively useless for some rare conditions. Diagnostic tests for rare conditions present a mathematical conundrum https://lnkd.in/gZD_6X3g

Learn how the Pin-point™ base editing platform induced fetal hemoglobin in HSPCs whilst retaining viability and high cell yields. Read poster. http://ms.spr.ly/6045YaI8X

Working in HSPCs? They're tricky. We've optimized conditions to deliver the Pin-point base editing platform to introduce a single base change that induces fetal hemoglobin expression - see the poster here!

Practically all diagnostic tests carry the risk of false positives, which can render results effectively useless for some rare conditions. Diagnostic tests for rare conditions present a mathematical conundrum https://lnkd.in/gZD_6X3g

Check out our brand new app note: High-Throughput Toxicity Assessment in OrganoReady® Blood Vessel HUVEC! Snakebites are a major global health issue, affecting millions either fatally or leaving them with permanent injury by disrupting blood vessels. In this app note, we describe an assay to assess vascular toxicity from various snake venoms in the OrganoReady® Blood Vessel HUVEC 3-lane 64 using a multimode microplate reader. 🔬 Key Highlights: - 64 ready-to-use 3D human blood vessels in the OrganoPlate® - Image-based protocols for real-time monitoring of endothelial barrier function, cell viability, and morphological changes - High-throughput assessment of vascular toxicity and inflammation 🔗 Read the app note: https://lnkd.in/eu6xYdSr #SnakebiteResearch #ToxicityAssessment #BiotechInnovation