#Reminder: Today (June 23) at 1:10 pm ET, Jeff Jacobs presents “Losmapimod, a p38 Small Molecule Inhibitor, Selectively Inhibits the DUX4 Program Without Negatively Impacting Myogenesis in FSHD.” Find his presentation and our posters at https://ow.ly/lrUh50Snjbj. #NewDirectionsInScience
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Introducing fluorinated substituents into biologically active molecules can improve their physicochemical properties, metabolic stability, and binding affinity (https://lnkd.in/dycW2wbA). Therefore, adding fluorinated moieties (e.g., CF3 or CHF2 groups) to the 1,3-functionalized cyclobutane ring is a promising design approach to advanced building blocks for early drug discovery. Try our trifluoromethyl cyclobutane building blocks in your research! https://lnkd.in/dyuvrjDc
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Are you looking for a deeper understanding of your lead candidates? 🔍 Gain specific kinetic insights into your compounds with our KinSight Time-Dependent Inhibition services. Whether your inhibition is time-dependent, reversible, or irreversible, we provide a comprehensive characterization of your compound, capturing valuable information for downstream discovery. Empower your research and accelerate your drug discovery journey with our state-of-the-art KinSight services. Learn more https://hubs.ly/Q02xtrFr0 #KinSight #TimeDependentInhibition #PhosphoSens #KinaseInhibitors #DrugDiscovery
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IMiD small molecule library ChemDiv’s collection of imide-like compounds for the discovery of PROTAC and molecular glue molecules contains 2,000 entries. Imide-like compounds provide the scientific background for discovering and developing PROTACs and molecular glue drug compounds, two innovative strategies in targeted protein degradation. These compounds act as crucial connectors or "glues" that facilitate the interaction between target proteins and the cellular degradation machinery via engagement with E3 ligase. https://lnkd.in/eTEBxRrY #IMiD
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The new degron system described in the article offers a promising avenue for target validation studies, especially for proteins of interest (POIs) lacking small molecule ligands. Its small size reduces the likelihood of independent ubiquitination and degradation, unlike larger tags, enhancing its suitability for evaluating POI degradability. doi: https://doi.org 10.1101/2024.03.15.585309 #protac #molecularglues #drugdiscovery
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Methyltriphenylphosphonium bromide is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. It is a lipophilic molecule and used to deliver molecules to specific cell components. Further, it acts as an antineoplastic agent.
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We’re excited to attend the 37th European Peptide Symposium in Florence! Join us to explore the latest trends in peptide synthesis and discover our groundbreaking UE-SPPS No Wash methodology. Let's discuss how this new technology is revolutionizing solid-phase peptide synthesis. Hope to see you there! #Peptides #PeptideSynthesis #EuropeanPeptideSymposium
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Separation of the final oligonucleotide product from its closest impurity is challenging, as these impurities are highly related to the full-length product. Download resource guide to see the Agilent complete workflows for oligonucleotide analysis to help you achieve accuracy and optimize speed. https://bit.ly/3TglsBD #oligonucleotidepurity #oligopurity #oligoimpurity
Download resource guide | Agilent
agilent.com
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Discover what's new in Therapeutic Oligonucleotides & Chromatography with Patrick Endres’s talk at 2:45 PM, part of IOPC 2024! Plus, don't forget to view Dr. Elena Kumm’s poster: Purification of a 100 Nucleotide ssDNA Oligomer using Anion Exchange Chromatography. Agenda available here: https://bit.ly/3VVSREd #ChromatographyExperts #Oligonucleotides #IOPC2024
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Regioselective Homolytic C2–H Borylation of Unprotected Adenosine and Adenine Derivatives via Minisci Reaction Effective for the late-stage borylation of some important biomolecules as well as a few antiviral and antitumor drug molecules, such as AMP, cAMP, Vidarabine, Cordycepin, Tenofovir, Adefovir, GS-441524. Preliminary antitumor evaluation, derivation of the C2-borylated adenosine to other analogues with high-value functionalities, along with the CuAAC click reactions, suggest the potential application of this methodology in drug molecular optimization studies and chemical biology. https://lnkd.in/gSB8Vr38
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Great to see this out there and a privilege to work with this team! Using DEL to identify and novel PAD2 inhibitor through an allosteric binding mechanism: https://lnkd.in/emcYvM4v
Discovery, Characterization, and Structure of a Cell Active PAD2 Inhibitor Acting through a Novel Allosteric Mechanism
pubs.acs.org
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