Flagship Pioneering reposted this
We're pleased to share new research in collaboration with NEO Proteomics that was published in ACS Publications. In addition to mapping the binding site of a crotonylated histone 3 peptide (H3K14Cr) to BAF45D, this study went on to demonstrate the direct binding of H3K14Cr to BRM. Overall, this study illustrates the power of mass spectrometry-based protein footprinting to map binding interfaces in large, multisubunit complexes with new insights into the BRG-/BRM-associated factor (BAF) chromatin remodeling complex. Read here: https://bit.ly/3xHHer0
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