European Society of Toxicology in Vitro ESTIV’s Post

The 3Rs principles - Replacement, Reduction and Refinement, were introduced by the British scientists William Russel and Rex Burch in their book “The Principles of Humane Experimental Technique” published in 1959. Since then, these principles have been established as a new framework for experimental research and as a roadmap for the development of protection policies for laboratory animals. Read more here: https://loom.ly/_PZCEiE #rabbitpyrogentest #pyrogentesting #pharma #biopharma #scientist #europeanunion #europe #animalprotection #animaltesting

🔬 "Challenges with Local Toxicity Assessment in Drug Development" 🔬 🚀 Key Insights: Understanding the gaps in traditional animal testing for drug development. Spotlight on the variability and ethical concerns of these methods. Emphasizing the shift towards human-centric testing platforms. Highlighting the costly pitfalls of current testing methods. 👀 Stay Tuned for More! The upcoming articles will explore non-clinical alternative methods meeting the challenges in toxicity testing and offer a sneak peek into the future of safer and more effective injectable drug development. 🔗 Dive in to explore more about the challenges and the imperative need for change in the field of drug development! https://lnkd.in/eM2Q-YaW

🌟 Check out this article 🌟 Some really interesting work here coming out of a Cheshire Lab. Taking initiative against the use of animal testing in Science by producing synthetic skin for use in testing of pharmaceutical and cosmetics!

The Emulate, Inc. Human Emulation System (HES, a.k.a Zoe and Orb) featured in this video is fundamentally cell agnostic - i.e. cultivation of your organ/tissue/disease state of interest uses the same equipment and chips. With over 35 tissues published in peer reviewed literature, including our seminal liver tox study for predictive validity of liver chip from 2022, the potential to accelerate drug development and incur cost savings is immense! Check out our website for more details on research thats been done with our HES or connect directly if you have interest in learning more. #organonchip #tox #research #FDA

🤝 Working hand in hand with the regulatory scientists, including at the #FDA, is an integral part of ensuring patient safety and reducing animal testing in the development of new therapeutics 🐀 Please watch the short video below to see how FDA scientists are working with Emulate, Inc. to support their understanding of #organonachip as they continue to inform their guidance on utilisation of human-relevant in vitro models during the drug discovery and development process.

The financial value of better models in drug R&D - better "decision tools" - is often hard for the inventor to capture (check out Hep C replicons, for example). The value of novel chemistry, on the other hand, is easy for the inventor to capture; hence so much investment in the discovery of new compounds which are tested in models that are widely regarded as lousy (e.g., cancer) and which then generally fail in human trials, versus less investment in models that might identify better compounds. It is great, therefore, to see the FDA evaluating organ chips. FDA acceptance is the kind of thing that will shift financial incentives in the right direction. Emulate, Inc.

Check out our latest article on a mechanism-based assessment of endocrine disrupting properties of #PFOS, based on AOPs and NAMs! 🎉 This project was A LOT of work and we identified several aspects that are important for the development of Next Generation Risk Assessment (#NGRA) of endocrine disruptors (EDs). In this paper, we compare a standard ED assessment against a mechanism-based assessment that did not utilize any in vivo data. Both assessments investigate thyroid disruption and developmental neurotoxicity caused by PFOS exposure. We utilize a thyroid-relevant Adverse Outcome Pathway (AOP) network to integrate data from New Approach Methodologies (NAMs) and to postulate a Mode-of-Action. Open access article available here: https://lnkd.in/dtxVsQK4 Thank you to all co-authors for your contributions to this great work: Marek Pípal, Jana Weiss, and Anna Beronius. #newapproachmethods #adverseoutcomepathways #karolinskainstitutet #chemicals #PFAS

Good one. I would not use them for predictivity in a human whole system as one organ communicates with hundred organs in a human. I use them to DESIGN MORE INFORMED AND OPTIMAL CLINICAL TRIALS. I also do not like to use the phrase ORGAN ON A CHIP. It is a misnomer. The organoids / spheroids are not really organs. They may mimic some physiological functions but not all. For example, hepatocyte-like cells differentiated from iPSC still grow in cell culture, where as primary human hepatocytes obtained from humans do not grow in cell culture. At the eend of the day, these are more advanced 3D cell co-culture systems compared to 2D static cell cultures which were used for several decades.