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🚀 Announcing the Deployment of ES/IODE New Version: 3.4.9 🎉 We are excited to inform you that ES/IODE, the leading online scientific research platform, has released version 3.4.9, now available as of August 20, 2024! This update brings significant enhancements to improve your research experience. What's New in This Version: 1️⃣ Science Image Feature: We've optimized the layout by centering the image area and seamlessly integrating the descriptive text within the image itself, offering better readability and a more polished presentation. 2️⃣ Scientific Review Feature: We've expanded our daily study selections with a new category focusing on Respiratory Medicine, Immuno-Allergology, and Dermatology. This addition provides access to the latest and most relevant studies in these rapidly evolving fields. We invite you to explore these new features today and continue leveraging the wealth of resources available on ES/IODE. For any questions or assistance, our support team is here to help. Thank you for your continued trust, and happy researching! 🧬🔬 ES/IODE - Innovating for Science.

📃Scientific paper: Antigenic and molecular characterization of low pathogenic avian influenza A(H9N2) viruses in sub-Saharan Africa from 2017 through 2019 Abstract: International audience; Sub-Saharan Africa was historically considered an animal influenza cold spot, with only sporadic highly pathogenic H5 outbreaks detected over the last 20 years. However, in 2017, low pathogenic avian influenza A(H9N2) viruses were detected in poultry in Sub-Saharan Africa. Molecular, phylogenetic, and antigenic characterization of isolates from Benin, Togo, and Uganda showed that they belonged to the G1 lineage. Isolates from Benin and Togo clustered with viruses previously described in Western Africa, whereas viruses from Uganda were genetically distant and clustered with viruses from the Middle East. Viruses from Benin exhibited decreased cross-reactivity with those from Togo and Uganda, suggesting antigenic drift associated with reduced replication in Calu-3 cells. The viruses exhibited mammalian adaptation markers similar to those of the human strain A/Senegal/0243/2019 (H9N2). Therefore, viral genetic and antigenic surveillance in Africa is of paramount importance to detect further evolution or emergence of new zoonotic strains. Continued on ES/IODE ➡️ https://etcse.fr/H6W ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Discrete patterns of microbiome variability across timescales in a wild rodent population Abstract: Mammalian gastrointestinal microbiomes are highly variable, both within individuals and across populations, with changes linked to time and ageing being widely reported. Discerning patterns of change in wild mammal populations can therefore prove challenging. We used high-throughput community sequencing methods to characterise the microbiome of wild field voles ( Microtus agrestis ) from faecal samples collected across 12 live-trapping field sessions, and then at cull. Changes in α- and β-diversity were modelled over three timescales. Short-term differences (following 1–2 days captivity) were analysed between capture and cull, to ascertain the degree to which the microbiome can change following a rapid change in environment. Medium-term changes were measured between successive trapping sessions (12–16 days apart), and long-term changes between the first and final capture of an individual (from 24 to 129 days). The short period between capture and cull was characterised by a marked loss of species richness, while over medium and long-term in the field, richness slightly increased. Changes across both short and long timescales indicated shifts from a Firmicutes-dominant to a Bacteroidetes-dominant microbiome. Dramatic changes following captivity indicate that changes in microbiome diversity can be rapid, following a change of environment (food sources, temperature, lighting etc.). Medium- and long-term patterns of change indicate an accrual of gut bacteria associated... Continued on ES/IODE ➡️ https://etcse.fr/K9T ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Strict Partitioning for Sporadic Rigid Gang Tasks Abstract: The rigid gang task model is based on the idea of executing multiple threads simultaneously on a fixed number of processors to increase efficiency and performance. Although there is extensive literature on global rigid gang scheduling, partitioned approaches have several practical advantages (e.g., task isolation and reduced scheduling overheads). In this paper, we propose a new partitioned scheduling strategy for rigid gang tasks, named strict partitioning. The method creates disjoint partitions of tasks and processors to avoid inter-partition interference. Moreover, it tries to assign tasks with similar volumes (i.e., parallelisms) to the same partition so that the intra-partition interference can be reduced. Within each partition, the tasks can be scheduled using any type of scheduler, which allows the use of a less pessimistic schedulability test. Extensive synthetic experiments and a case study based on Edge TPU benchmarks show that strict partitioning achieves better schedulability performance than state-of-the-art global gang schedulability analyses for both preemptive and non-preemptive rigid gang task sets. ;Comment: to be published in IEEE Real-Time and Embedded Technology and Applications Symposium (RTAS 2024) Continued on ES/IODE ➡️ https://etcse.fr/MtW9S ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Genetic Testing in Parkinson's Disease Abstract: Genetic testing for persons with Parkinson's disease is becoming increasingly common. Significant gains have been made regarding genetic testing methods, and testing is becoming more readily available in clinical, research, and direct‐to‐consumer settings. Although the potential utility of clinical testing is expanding, there are currently no proven gene‐targeted therapies, but clinical trials are underway. Furthermore, genetic testing practices vary widely, as do knowledge and attitudes of relevant stakeholders. The specter of testing mandates financial, ethical, and physician engagement, and there is a need for guidelines to help navigate the myriad of challenges. However, to develop guidelines, gaps and controversies need to be clearly identified and analyzed. To this end, we first reviewed recent literature and subsequently identified gaps and controversies, some of which were partially addressed in the literature, but many of which are not well delineated or researched. Key gaps and controversies include: (1) Is genetic testing appropriate in symptomatic and asymptomatic individuals without medical actionability? (2) How, if at all, should testing vary based on ethnicity? (3) What are the long‐term outcomes of consumer‐ and research‐based genetic testing in presymptomatic PD? (4) What resources are needed for clinical genetic testing, and how is this impacted by models of care and cost‐benefit considerations? Addressing these issues will help facilitate the ... Continued on ES/IODE ➡️ https://etcse.fr/J5xw ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Eculizumab for adult patients with atypical haemolytic-uraemic syndrome: full dataset analysis of Japanese post-marketing surveillance Abstract: Background Eculizumab has been approved for atypical haemolytic-uraemic syndrome (aHUS) in Japan since 2013. Post-marketing surveillance enrolled patients with aHUS who received ≥ 1 dose of eculizumab to assess eculizumab safety and effectiveness. Methods We evaluated serious adverse events and effectiveness endpoints, i.e., haematologic normalization, a decrease of ≥ 25% in serum creatinine (sCr) levels, and complete thrombotic microangiopathy (TMA) response in adult patients with aHUS without other underlying diseases. In addition, the difference of baseline characteristics between patients who did and did not meet effectiveness endpoints was examined. Results In this safety and effectiveness analysis, 79 adult patients were included; median age was 54.0 years, median treatment duration was 30 weeks. Total exposure time of eculizumab was 75.51 patient-years, and 94 serious adverse events were reported in 39 patients. No unexpected safety signals were identified in this population. Mean platelet count, lactate dehydrogenase and estimated glomerular filtration rate significantly improved after 7 days of treatment. Complete TMA response, haematologic normalization and the improvement of sCr levels were met by 35.3%, 40.4% and 51.3% of patients, respectively. Median treatment duration was shorter in patients who did not achieve complete TMA response (6 weeks) than in patients who did (114 weeks). Multivariate analysis suggested that the time from the most recent TMA... Continued on ES/IODE ➡️ https://etcse.fr/X18 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Alzheimer's Magnetic Resonance Imaging Classification Using Deep and Meta-Learning Models Abstract: Deep learning, a cutting-edge machine learning approach, outperforms traditional machine learning in identifying intricate structures in complex high-dimensional data, particularly in the domain of healthcare. This study focuses on classifying Magnetic Resonance Imaging (MRI) data for Alzheimer's disease (AD) by leveraging deep learning techniques characterized by state-of-the-art CNNs. Brain imaging techniques such as MRI have enabled the measurement of pathophysiological brain changes related to Alzheimer's disease. Alzheimer's disease is the leading cause of dementia in the elderly, and it is an irreversible brain illness that causes gradual cognitive function disorder. In this paper, we train some benchmark deep models individually for the approach of the solution and later use an ensembling approach to combine the effect of multiple CNNs towards the observation of higher recall and accuracy. Here, the model's effectiveness is evaluated using various methods, including stacking, majority voting, and the combination of models with high recall values. The majority voting performs better than the alternative modelling approach as the majority voting approach typically reduces the variance in the predictions. We report a test accuracy of 90% with a precision score of 0.90 and a recall score of 0.89 in our proposed approach. In future, this study can be extended to incorporate other types of medical data, including signals, images, and other data. The same or altern... Continued on ES/IODE ➡️ https://etcse.fr/QfHgY ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you. #alzheimer #science #health

📃Scientific paper: Neonatal reference intervals for thyroid stimulating hormone and free thyroxine assayed on a Siemens Atellica® IM analyzer: a cross sectional study Abstract: Background Deriving population specific reference intervals (RIs) or at the very least verifying any RI before adoption is good laboratory practice. Siemens has provided RIs for thyroid stimulating hormone (TSH) and free thyroxine (FT4) determined on their Atellica® IM analyzer for all age groups except the neonatal age group which provides a challenge for laboratories that intend to use it to screen for congenital hypothyroidism (CH) and other thyroid disorders in neonates. We set out to determine RIs for TSH and FT4 using data obtained from neonates undergoing routine screening for CH at the Aga Khan University Hospital, Nairobi, Kenya. Methodology TSH and FT4 data for neonates aged 30 days and below were extracted from the hospital management information system for the period March 2020 to June 2021. A single episode of testing for the same neonate was included provided both TSH and FT4 were done on the same sample. RI determination was performed using a non-parametric approach. Results A total of 1243 testing episodes from 1218 neonates had both TSH and FT4 results. A single set of test results from each neonate was used to derive RIs. Both TSH and FT4 declined with increase in age with a more marked decline seen in the first 7 days of life. There was a positive correlation between logFT4 and logTSH (r_s (1216) = 0.189, p = < 0.001). We derived TSH RIs for the age groups 2–4 days (0.403–7.942 µIU/mL) and 5–7 days (0.418–6.319 µIU/mL), and sex specific RIs for ... Continued on ES/IODE ➡️ https://etcse.fr/zjHn6 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: CURLING - I. The Influence of Point-like Image Approximation on the Outcomes of Cluster Strong Lens Modeling Abstract: Cluster-scale strong lensing is a powerful tool for exploring the properties of dark matter and constraining cosmological models. However, due to the complex parameter space, pixelized strong lens modeling in galaxy clusters is computationally expensive, leading to the point-source approximation of strongly lensed extended images, potentially introducing systematic biases. Herein, as the first paper of the ClUsteR strong Lens modelIng for the Next-Generation observations \(CURLING\) program, we use lensing ray-tracing simulations to quantify the biases and uncertainties arising from the point-like image approximation for JWST-like observations. Our results indicate that the approximation works well for reconstructing the total cluster mass distribution, but can bias the magnification measurements near critical curves and the constraints on the cosmological parameters, the total matter density of the Universe $\Omega\_\{\rm m\}$, and dark energy equation of state parameter $w$. To mitigate the biases, we propose incorporating the extended surface brightness distribution of lensed sources into the modeling. This approach reduces the bias in magnification from 46.2 per cent to 0.09 per cent for $\mu \sim 1000$. Furthermore, the median values of cosmological parameters align more closely with the fiducial model. In addition to the improved accuracy, we also demonstrate that the constraining power can be substantially enhanced. In conclusion, it is necessary to model cluster-... Continued on ES/IODE ➡️ https://etcse.fr/mS7nU ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: CD20^ T cells: an emerging T cell subset in human pathology Abstract: Introduction Although CD20 is classically a B cell marker, in the last three decades, dim expression has been noted on a subset of T cells as well that has been independently verified by a number of groups. Our understanding of these cells and their function is not well established. Methods A thorough review of original articles on CD20^ T cells was undertaken of Pubmed by using combination of phrases including “CD20^ ”, “CD20-positive” and “T cells”. Articles in English were considered, and there was no time restriction. Results CD20^ T cells express the standard T cell markers and, in comparison to CD20¯ T cells, appear to express greater inflammatory cytokines and markers of effector function. Although the ontogeny of these cells is still being established, the current theory is that CD20 may be acquired by trogocytosis from B cells. CD20^ T cells may be found in healthy controls and in a wide range of pathologies including autoimmune diseases, haematological and non-haematological malignancies and human immunodeficiency virus (HIV) infections. One of the best studied diseases where these cells are found is multiple sclerosis (MS) where a number of therapeutic interventions, including anti-CD20 depletion, have been shown to effectively deplete these cells. Conclusion This review summarises the latest understanding of CD20^ T cells, their presence in various diseases, their putative function and how they may be an ongoing target of CD20-depleting agents. Unfo... Continued on ES/IODE ➡️ https://etcse.fr/4pRVf ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.