Eppendorf ’s Post

👩🏼🔬 #GRI3D FEATURE | SUN bioscience’s microwell technology is unleashing efficiency and precision! SUN bioscience is elevating organoid research through its #Gri3D technology. Our 96 well-plate showcases 2 unique #features: 1) Multiple hydrogel-based U-bottom-shaped microcavities in each well, effortlessly increasing the #throughput.  2) A pipetting port, situated on the side of each well, allowing for safe and easy media exchange without microtissue loss.  🧪 The resulting microtissues are #uniform in size and precisely located in predefined positions, the cell-repellent #hydrogel microwells, where they float. While displaying homogeneous size, they maintain their inherent heterogeneity in shape. We offer the possibility to test #Gri3D with our sample plate format – send us an email, receive your sample, seed your cells, add your media, and let #biology do the rest! 📩 Contact us at [email protected] or visit our website (https://sunbioscience.com/) to learn more! #Gri3D #highthroughput #imagingpower #3Dcellculture #solvingchallenges

I'm happy to share with you that I've finished this course that talks about (Bioprocess development) it was really informative and valuable if you are interested in this field. This course is talking about the fermintation process and the difference between fermintation methods and the fundamentals of Microbial Bioreaction Design and the types of different Bioreactors that are commonly used for biomanufacturing processes. Also it gives you an overview about Upstream and Downstream processing. #bioprocessing #biomanufacturing #fermentation #microbiology

Discover the optimal controlled environment for studying your 3D samples: The CERO 3D Incubator & Bioreactor. Mimicking natural cell growth, it sets a new standard in precision, fine-tuning environmental parameters to ensure consistent and reliable research outcomes. Key Benefits: > Enhance organoid viability & maturation. > Maximize homogeneity & long-term cultivation (1 year). > Optimize yields with reproducible conditions. > Work Smarter, Not Harder: Efficiently manage multiple experiments and scale up with ease. Learn more here: https://lnkd.in/eekCC7J8 #CERO3D #cellculture #iPSC #stemcells #celltherapy #cancerresearch #cellbiology

[Improved performance] The purification process for exosomes is a challenging task. 🔎 But we’ve development of a robust and high-throughput method that enables a comprehensive evaluation of extracellular vesicles (EVs) in complex samples. 💡 The developed 2D SEC-AEX method takes 30 minutes and the result of the analysis is a detailed sample profile that displays:  1) sample components resolved by their size 2) heterogeneity of particles, resolved by their charge   Read on: https://lnkd.in/d_TUceR4 #EV #purification #monoliths #exosome #biotech #chromatography

Overview of 3-Fluoro-2-nitropyridine CAS Number: 54231-35-5 Molecular Formula: C₅H₃FN₂O₂ 3-Fluoro-2-nitropyridine is a specialty chemical widely utilized in proteomics research and various fields of organic synthesis. This compound is particularly valued for its role in the synthesis of complex chemical entities. #3Fluoro2nitropyridine

I am thrilled to present my latest work entitled, " A General Charge Transfer Assembly Driven Photoactivation Platform of Diaryliodonium Reagents: Arylation of Heterocycles" at #RSCPoster conference. Here, we have developed an economical and effective transition-metal-free photoinduced method to generate aryl radicals, which involves the formation of a tetrameric charge transfer assembly (CTA) between DAIRs, NaI, PPh3, and TMEDA. Under mild and sustainable reaction condition, our photoinduced electron donor-acceptor (EDA) approach enables arylation of a plethora of nitrogen and oxygen containing aromatic and non-aromatic heterocycles. This success translates into the generation of arylated heterocyclic scaffolds with therapeutic potential, showcasing the practical utility of our methodology in the modification of drugs. Please feel free to ask any questions. Thank You #RSCPoster #RSCPosterPitch #RSCOrg #RSCPoster2024 #sustainability #Organicsynthesis #photoredox

🔎 Automation of 18F-labelled branched chain amino acids synthesis 🔎 The relatively long half-life of fluorine-18 (110 mins) and its favourable decay profile (97% positron emission) make 18F-labelled compounds attractive radiotracers for use in positron emission tomography (PET), a medical imaging technique. The development of new 18F-labelled molecules is crucial in order to be able to expand the use of PET as a diagnostic tool for different disease areas. Working with radiolabelled compounds presents extra challenges due to the potential exposure to radiation throughout the process. In this manuscript, Schaffer, Britton and coworkers report the design and implementation of an automated flow module for the 18F-fluorination of branched-chain aliphatic amino acids. By automating this flow procedure, the authors were able to achieve higher molar activity, enhanced reproducibility, and reduced radiation exposure, exemplified by the radiosynthesis of 5-[18F]FHL – obtained with a radiochemical yield of 20.1 ± 4.8% (n = 3), a radiochemical purity of 94.5 ± 4.9% (n = 3), and a synthesis time of ~75 min. Read the paper to find out more about their system! 🗒 Design and implementation of an automated DT-PhotoFluor radiosynthesis module for 18F-fluorination of aliphatic, branched chain amino acids 🌐 https://lnkd.in/d3JHRG8T ✍ Gökçe Engüdar, Zheliang Yuan, Matthew Nodwell, Hua Yang, Chelsea Currie, Stuart McDiarmid, Robert Britton, and Paul Schaffer This article is part of our part of a special Issue: Emerging Investigators in Flow Chemistry 2023. Follow us for more updates from the Journal of Flow Chemistry 📰 #flowchemistry #JFC #flowchemistrysociety #radiosynthesis #18F_fluorination #automation

Checkout the PrecisionPak™ Complete Lysis & Extraction Kits by Next Advance — available now at FroggaBio! Streamlined solution for high-quality biomolecule extractions. 🧬🔬🐸 LEARN MORE: https://hubs.li/Q02Fn-Xh0 The PrecisionPak™ offers a streamlined, customized solution for high-quality and high-yield biomolecule extractions from many sample types. Bundling bead lysis and extraction kits with a customized protocol, it includes additional reagents typically purchased separately. This all-in-one package ensures all necessary components for tissue homogenization and biomolecule isolation, available in various tube sizes and optimized for specific samples. #FroggaBio #PrecisionPak #NextAdvance #LysisKits #ExtractionKits #BiomoleculeExtraction #HighYieldExtraction #QualityExtraction #StreamlinedProtocols #BiotechSolutions #LaboratoryTools #MolecularBiology #DNAExtraction #RNAExtraction #MagneticBeadTechnology #CustomProtocols #ComprehensiveKits #LaboratoryEfficiency #ResearchTools #BiologicalResearch #TissueHomogenization #SamplePreparation #LabOptimization #ScientificResearch #BiomedicalResearch #BiotechProducts #MolecularTools #LaboratorySupplies #SampleProcessing #HighQualityResults #EfficientWorkflows

Skeletal editing is definitely a hot topic. Phenyl to pyridyl editing methodologies have been recently disclosed by the Burns, Levin or Xu groups (among others). Yet I find the conversion of pyridyl to phenyl even more exciting as pyridines are often a convenient handle to activate and functionalize aromatic rings (SNAr, Minisci, Chichibabin, etc...). Here are two different studies that address the same issue: one by Sorensen and coworkers relies on pyridine oxides (https://lnkd.in/ebJkSwVY) and the second one by Studer and coworkers (https://lnkd.in/eFBZZFCD). Certainly useful tools for late stage functionalization

Today BioLife Solutions, Inc. launches the ThawSTAR® CSV, an Automated Thawing System that is compatible with our CellSeal® Cryogenic Vials and CellSeal® Connect Vials. Why Choose ThawSTAR CSV? 🧪 Reduces variability and your manual processes with steady thaw rates, no matter who is operating the system or where they are located. 🧪 Enables qualifiable thawing algorithms of your frozen CellSeal vials each time. 🧪 The water-free design eliminates certain contamination risks common in water or bead baths. Check it out to find out more. #cellthawing #cellseal #vials #vialthawing #GMP