Elsie Biotechnologies’ Post

Check our new Nature Communications paper detailing a novel metal-free photocatalytic cross-electrophile coupling that enables C1 homologation and Csp3-Csp3 coupling. 🔗 https://lnkd.in/eQ2RE-K9 Abstract: In contemporary drug discovery, enhancing the sp3-hybridized character of molecular structures is paramount, necessitating innovative synthetic methods. Herein, we introduce a deoxygenative cross-electrophile coupling technique that pairs easily accessible carboxylic acid-derived redox-active esters with aldehyde sulfonyl hydrazones, employing Eosin Y as an organophotocatalyst under visible light irradiation. This approach serves as a versatile, metal-free C(sp3)−C(sp3) cross-coupling platform. We demonstrate its synthetic value as a safer, broadly applicable C1 homologation of carboxylic acids, offering an alternative to the traditional Arndt-Eistert reaction. Additionally, our method provides direct access to cyclic and acyclic β-arylethylamines using diverse aldehyde-derived sulfonyl hydrazones. Notably, the methodology proves to be compatible with the late-stage functionalization of peptides on solid-phase, streamlining the modification of intricate peptides without the need for exhaustive de-novo synthesis. Great collaborative work by Stefano Bonciolini, Antonio Pulcinella, Matteo Leone, Debora Schiroli, Adrián Luguera Ruiz, Andrea Sorato, Maryne, Ranganath Gopalakrishnan, Géraldine Masson, Nicola, Stefano, Maurizio, Eli Zysman-Colman, Magnus J Johansson and Timothy Noel Funding by PhotoReAct and Chair ITN! #SyntheticMethodology, #FlowChemistry, #peptide, #crosscoupling. #metalfree

Molecular glues are small-molecule protein degraders with physical-chemical advantages over proteolysis targeting chimeras (PROTACs), but with very little rational for their design. Thus, methods for the efficient and rapid synthesis of librairies are instrumental to the discovery of new molecular glues. In this report, the groups of Kitamura and Erb disclose the use of SuFEX chemistry to quickly synthesize over 3000 analogues of 5’-amino lenalidomide for direct-to-biology screening, and four were resynthesized and shown to degrade the GSPT1 protein. In the future, this proof-of-concept should be applied to more challenging targets. #SpiroChem #molecularglues https://lnkd.in/eSMUyBXT

Novel fluorescent probes with improved stability and affinity for Gαi1 protein! A new generation of GTP analogs labeled with 5-FAM show improved hydrolytic stability and binding affinity for Gαi1 protein compared to commonly used MANT and BODIPY FL GTPγS. Read more: https://lnkd.in/dYbjKC2S #jenabioscience #biochemistry #signaltransduction #nucleotides

Delve into the effects of enzyme inhibition on substrate availability. Learn how inhibitors can significantly alter the breakdown process, resulting in increased substrate levels. Explore the complex interplay between inhibitors and substrates in enzyme function. Gain a deeper understanding of enzyme regulation and its implications. 🧪 #EnzymeInhibition #SubstrateAvailability #Biochemistry

Here is our latest pre-print focusing on the scaled up enzymatic synthesis of 2'deoxy nucleoside analogues. We explore the reaction scope of nucleoside transglycosylase II and demonstrate the scalability of the process to prepare high value nucleoside building blocks. We also establish a structural basis of the mechanism of transglycosylation which proceeds via covalent catalysis. This was collaborative work with Gideon Grogan and Alex Ascham (York), and Admir Salihovic Andrea Taladriz Sender and Paul Hoskisson Strathclyde Faculty of Science Work was funded by BBSRC The Leverhulme Trust #chemicalbiology #oligonucleotide #biocatalysis

Check out a pre-print of some of the research from my PhD where we showcase the enzymatic synthesis of a range of 2'deoxy nucleoside analogues. We define the substrate scope and show structural basis of covalent catalysis. https://lnkd.in/eFc6KUTK #DNA #biocatalysis #sustainability

Greening peptide synthesis♻️

Delve into the effects of enzyme inhibition on substrate availability. Learn how inhibitors can significantly alter the breakdown process, resulting in increased substrate levels. Explore the complex interplay between inhibitors and substrates in enzyme function. Gain a deeper understanding of enzyme regulation and its implications. 🧪 #EnzymeInhibition #SubstrateAvailability #Biochemistry #pmhnp #npexamcoach

#Cryopreservation_Media Market Growth Set to Surge Significantly during 2023-2032 >> https://lnkd.in/gvRjbF8e #Cryopreservation #media is a #chemically defined solution used to preserve #organelles, #cells, #tissues, and organs from contamination by #freezing and #thawing. Thermo Fisher Scientific, Merck, zenoaq, STEMCELL Technologies, GE HealthCare, Bio-Techne, Lonza, Biological Industries Trading, NIPPON Genetics EUROPE #medical #chemical #cooling #bioactivity #biotechnology

Luca MIAC 2023 We were there, and you? Couldn't get through? Don't worry! Contact us to find out about new technologies of NCR Biochemical. "Innovation is inventing tomorrow with what we have today" #NCR #NCRBiochemical #rckchemicals #chemistry #flowcytometry #stickies #enzyme #technology #miac #innovation #mind #paper #tissue #paperindustry #papertechnology