Dynamic42 GmbH’s Post

[𝐍𝐞𝐰 𝐛𝐥𝐨𝐠] Spheroid-on-chip – Combining the benefits of dynamic cell culture with the complexity of spheroids In recent years, the integration of spheroids and organoids with microfluidic chip technology has become a growing trend in biomedical research. This combination, often referred to as "spheroid-on-chip" or “organoid-on-chip”, provides a dynamic, but also highly controlled environment that more accurately mimics the complexity of in vivo tissue when compared to traditional culture methods. You can read it here: https://shorturl.at/tvg56

🌐 What Are Spheroids? 🌐   Spheroids are transforming how we study cellular behavior. Unlike traditional 2D cultures, these 3D cell aggregates closely resemble the natural architecture and function of tissues. This similarity makes them invaluable for research that requires realistic cell-cell and cell-matrix interactions.   🧫 What Exactly Are Spheroids? These compact, spherical structures are formed when cells are suspended in a culture medium and naturally aggregate. The process is driven by cell-cell interactions, such as integrin-ECM binding and cadherin expression. The result? A microenvironment that can include various cell types—epithelial, mesenchymal, endothelial—mirroring what we find in actual tissues. Spheroids can be created using cell lines, single cells, or even tissue-derived cells from biopsies. This versatility makes them a powerful tool for biomedical research! 🔬   🧬 Why Are They So Special? One key characteristic is their ability to develop distinct layers, similar to the spatial organization in solid tumors or tissues. These layers often include: Outer Proliferating Zone: Active cell growth and division. Intermediate Quiescent Zone: Cells in a state of dormancy. Central Necrotic Core: Especially in larger spheroids, mimicking the natural oxygen and nutrient gradients found in tissues. 🌐 This layered structure allows researchers to explore cellular behaviors and drug responses in conditions that closely resemble the human body. 🚀 Spheroids are not just a step forward - When combined with on-chip technology they're a leap toward more accurate, in vivo-like research models. 🌟   #Spheroids #3DCellCulture #BiomedicalResearch #CellBiology #InVivoModeling

Organ-on-chip as an alternative to animal testing.   Did you know we offer an objective and scientific introduction to organ-on-chip technology for animal facilities and other institutions as part of a free, remote 3R education?   The presentation will include different approaches, manufacturers, strengths, challenges and a Q&A session.   Interested? Get in touch here on LinkedIn or via our website.

We are proud to say that the project of our scientist Joanna Nowacka will be financed by the directive of the Free State of Thuringia on the Promotion of Research, Technology and Innovation (FTI, Project nb. 2024 VFE 0050).   Joanna will be working on a vascularized liver-on-chip model for personalized compound testing (Vascu Chip). Within her work, Joanna will be developing stem cell cultures into “pluripotent” stem cells, from which she can then differentiate multiple cell types.   Joanna says: “I believe organ-on-chip technology represents the future of drug testing models. I am eager to join Dynamic42 to contribute my stem cell expertise to their already remarkable platforms.”

💡 Did you know that Dynamic42 GmbH maintains a quality management system certified according to ISO 9001:2015 standards? All our manufacturing and contract research work is performed according to strict quality management guidelines. In a recent quality audit conducted by Dekra Certification GmbH, our quality management has been tested, and we are proud to say that we have passed the requirements of a quality management system according to DIN EN ISO 9001:2015. We are delighted by the positive outcome and will strive to continue to deliver outstanding products and service to our customers.

Could this be you? We are looking for an enthusiastic and proactive individual to join our team as an Application Specialist. You have a degree in the life sciences, experience in cell biology or organ-on-chip, like to travel and have an open and self-confident nature? Apply today to join our young, open-minded and committed team! You will have broad development opportunities, you can help to shape the company and realize your own potential. We offer a fair basic salary, performance-related special payments and flexible organization of everyday working life. Apply & learn more here: https://lnkd.in/eXQXVYa5

Investigating the pharmacokinetic properties of drugs in a biochip-based organ model.   This was what we had in mind 18 months ago when we launched a project funded as part of the Sanofi iDEA-iTECH Award Program.   Recycling, viability and vascular permeability of two frequently used mAbs were analyzed using our liver-on-chip model.   “We were able to verify the recycling process of therapeutic antibodies without compromising cell viability or tissue integrity. Our model helps to overcome the species specificity of animal models and thereby can reduce the frequency of failures in clinical trials.” Anne-Katrin Bothe Senior Scientist at Dynamic42 GmbH, summarizes the results.   Initial results were presented at this year's MPS World Summit in Seattle in mid-June and at the annual meeting of the European Organ-on-chip society (EUROoCS) in Milan at the beginning of July.   The project partners aim to continue their joint efforts on innovative organ-on-chip technology for the characterization of the disposition of new therapeutic antibodies. Learn more here: https://shorturl.at/KldoG

Over the past decade, the field of microphysiological systems has flourished, especially with organ-on-chip technologies. However, adoption in the industry faces challenges due to the lack of regulatory guidelines and standardization. A classification system proposed by Viraj Mehta seeks to categorize organ-on-chips based on their design and functionality, paving the way for clearer regulatory guidelines, accelerated innovation, and improved educational resources. #organonchip #ooccs #mps