[Guest article] Organ-on-chip technology transforms infectious disease modelling Our most recent guest article, published in SelectScience, talks about how organ-on-chip technology can improve the understanding of host-pathogen interactions and the evaluation of antimicrobial treatments. You can find the article here: https://zurl.co/JEmT
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Research Assistant at Wayne State University, studying Legionella pneumophila, bacterial pathogenesis, and host immunity in Dr. Pei-Chung Lee's Lab
Check out our newly published research article investigating the role of the Hippo kinases, MST1 and MST2, in regulating inflammatory gene expression and limiting bacterial replication!
I am incredibly excited to share our new publication: The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes. In this research article, we demonstrate novel and distinct roles for the Hippo kinases, MST1 and MST2, in macrophage-dependent immunity and provide insight into how MST1/2 are involved in restricting bacterial infection. Special thank you to all co-authors: Sydney Quagliato, Lee Pei-Chung, YuTing Su https://lnkd.in/gCs4DAzz
The Hippo kinases control inflammatory Hippo signaling and restrict bacterial infection in phagocytes | mBio
journals.asm.org
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Scientist, RAN BioLinks co-founder: Driven by a passion for science and innovative solutions to accelerate research
A new study led by researchers at UCL and the Wellcome Sanger Institute showed the important differences in how the nasal cells of kids, young adults and elderly people respond to the SARS-CoV-2 virus, could explain why children typically experience milder COVID-19 symptoms. They focused on the early effects of SARS-CoV-2 infection on the cells first targeted by the virus, the human nasal epithelial cells (NECs). The strong antiviral response in the NECs of children could explain why younger people typically experience milder symptoms. In contrast, the increased damage and higher viral replication found in NECs from elderly individuals could be linked to the greater severity of disease observed in older adults. Check the details out in this very comprehensive publication: https://lnkd.in/gehn6RSK
Age-specific nasal epithelial responses to SARS-CoV-2 infection - Nature Microbiology
nature.com
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Veterinarian | Molecular Biologist | Molecular Entomologist | Molecular Parasitologist | Vector Biologist | Microbiome | Bioinformatics | Next Generation Sequencing (NGS) |
Thrilled to announce the publication of a crucial aspect of my PhD research conducted at The University of Southern Mississippi. This accomplishment wouldn't have been possible without the support of my advisor Shahid Karim and the collaborative efforts of Ryan Smith and Jose Ribeiro. In our study, we employed single-cell technology to investigate the transcriptomic changes in hemocytes (immune cells) of the Lone Star tick when in response to Ehrlichia infection and blood-feeding. 1. Our results revealed substantial heterogeneity in hemocyte populations, particularly noteworthy changes in those infected with the intracellular pathogen, E. chaffeensis. Utilizing trajectory analysis, we identified major lineages within the hemocyte clusters. 2. Recognizing the challenge of functionally characterizing the identified genes, we focused on genes abundant in clusters enriched in E. chaffeensis-infected cohorts for clearer insights. Silencing hemocytin, fibronectin, lipocalin, and cystatin had a notable impact on the overall hemocyte population, suggesting their role in maintaining homeostasis within the tick vector. 3. One of the most intriguing findings of the study is the specific influence of silencing certain genes on Ehrlichia infection in the entire tick. Silencing hemocytin and lipocalin resulted in a higher pathogen load, correlating with a decrease in granulocytes and plasmatocyte count. These findings contribute significantly to our understanding of tick immune biology and their responses to microbial infection, providing valuable insights for future research on vector control #singlecell #entomology #tickcontrol
Happy to finally get this work out there: Adegoke A, Ribeiro JMC, Smith RC and Karim S (2024) Tick innate immune responses to hematophagy and Ehrlichia infection at single-cell resolution. Front. Immunol. 14:1305976. doi: 10.3389/fimmu.2023.1305976. Great work Abdulsalam Adegoke!! Many thanks to everyone involved, especially Jose Ribeiro and Ryan Smith. https://lnkd.in/gMkKS3xK
Tick innate immune responses to hematophagy and Ehrlichia infection at single-cell resolution
frontiersin.org
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Happy to share our latest publication just out in JHEP Reports!
Our new paper just published in JHep Reports shows that Peg-IFN enhances the kinetics of viral decline in HDV infected patients treated with bulevirtide. While infection with Hepatitis Delta virus remains the most severe form of chronic hepatitis infection, our results show that the combination of bulevirtide and Peg-IFN have the potential to accelerate the clearance of the virus, with potential implications for cure. These results have been made possible thanks to the fantastic modeling work of PhD student Selma El Messaoudi, using the data from the Buledelta cohort conducted by ANRS Maladies infectieuses émergentes ! Thanks to all our collaborators that made this study possible, in particular Victor de Lédinghen, Jean-Michel Pawlotsky, Claire FOUGEROU-LEURENT, Ségolène Brichler !
Effect of Peg-IFN on the viral kinetics of HDV infected patients treated with bulevirtide
sciencedirect.com
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Our work just published in MIcrobes and Infection, December 23 2023, reveals a novel role for receptor 210 in endocytic sorting and recognition of influenza A virus in macrophages. https://lnkd.in/enZNEW9M
SP-R210 isoforms of Myosin18A modulate endosomal sorting and recognition of influenza A virus infection in macrophages
sciencedirect.com
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📣 New Study Alert! Dive into the impact of #COVID19 on hospital-acquired infections at a comprehensive cancer center. 🏥 APIC Highlights: 1️⃣ Measures during the pandemic impact hospital-acquired infections. 2️⃣ Decrease in nosocomial respiratory viral infections. 3️⃣ Significant drop in CLABSI incidence. 4️⃣ Higher incidence of multidrug-resistant organisms on COVID-19 wards. Explore the findings: https://lnkd.in/gEn3dKZX #InfectionPrevention #HealthResearch
The impact of the COVID-19 pandemic on hospital-acquired infections at a comprehensive cancer center
ajicjournal.org
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Really pleased to see our work published in BBRC underpinning the potential utility of cysteamine in treating respiratory infection. In this case, improving epithelial cell responses to viral infection by temporarily inhibiting the activity of glycine decarboxylase (GLDC), boosting interferon lambda production, while inhibiting IL-6. Cysteamine is a naturally occurring molecule and an advance stage clinical candidate for exacerbations in cystic fibrosis, non-CF bronchiectasis and community acquired pneumonia (CAP), where it is in phase III development. This adds another potential string to the bow of this multi-active molecule which has decades of safety data as it is already licenced for an unrelated condition. https://lnkd.in/e_7FyM7Z https://lnkd.in/eyvJud2k
Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection
sciencedirect.com
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Neutralising #antibodies that target #resistant bacteria #Antibiotic-resistant bacteria pose a major challenge to healthcare systems worldwide. Due to numerous resistance mechanisms, infections with the pathogen #Pseudomonas aeruginosa are particularly feared. Researchers at the German Center for Infection Research, the University Hospital Cologne, the Helmholtz Centre for Infection Research in Braunschweig and the University Medical Center Hamburg-Eppendorf have now discovered antibodies that could lead to a highly potent treatment option of acute and chronic infections with P. aeruginosa. The study was published in the prestigious scientific journal Cell Press. https://lnkd.in/eiK4PfmC Helmholtz-Zentrum für Infektionsforschung Uniklinik Köln Universitätsklinikum Hamburg Eppendorf Jan Rybniker #AMR #AntimicrobialResistance #PseudomonasAeruginosa #InfectiousDiseases #MedicalResearch #Healthcare #NewTreatment #CellJournal #HealthChallenges
Neutralising antibodies that target resistant bacteria
dzif.de
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The most important point of this study is that the novel method can be used to determine the number of bacteria in a sample as a novel biomarker of infectious diseases. https://lnkd.in/e5m5j7Z2
Novel rapid method for identifying and quantifying pathogenic bacteria within four hours of blood collection - Scientific Reports
nature.com
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Bordetella hinzii colonies on blood agar isolated from respiratory sample of a patient and identified by 16S rRNA sequencing Points to note: Not all Bordetella detected in respiratory samples are B pertussis Not all Bordetella cause whooping cough Not all PCRs for Bordetella are pertussis specific A positive PCR for B pertussis may detect a non pertussis species in 1 to 3% of cases Species specific PCRs for Bordetella pertussis may be designed to confirm initial positives especially if the CT value is >29 Pertussis may present without whooping cough among patients with comorbidities and those with cancer Adult perussis is very much possible especially those with immunosuppression PCR may detect colonization rather than infection PCR may also detect non pathogenic or non pertussis Bordetella species Non pertussis Bordetella species can rarely cause disease doi: 10.3201/eid2711.211468 PMCID: PMC8544983 PMID: 34388087 Bordetella hinzii Pneumonia and Bacteremia in a Patient with SARS-CoV-2 Infection
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