Diatech Pharmacogenetics’ Post

Want to learn more about the TROPION-Lung01 trial? Dana-Farber Cancer Institute's Dr. Jacob Sands dives into the data on OncLive, comparing the results of datopotamab deruxtecan versus docetaxel in non-squamous non-small cell lung cancer. Great overview! Check out the video. #lungcancer #cancer #oncology https://lnkd.in/e85tyyZe

#ICYMI At #AACR24, We presented results from our study, “Detection of non-small cell lung cancer and bladder cancer signatures in peripheral blood using a novel active chromatin capture assay.” In honor of Cancer Research Month, we share this study, which provides insights into the changes that could benefit therapeutic approaches to targeting tumor micro-environments in non-small cell lung and bladder cancer.  See the full poster here: https://lnkd.in/eWAHiBqn #NCRM24 #Cancerresearch #Cancer #blood #assay

In the second SLAS journals capsule collection focusing on lung cancer, researchers from Emory University School of Medicine and Memorial Sloan Kettering Cancer Center illustrate a method for a high-throughput assay for the identification of heat shock protein 90 (Hsp90) inhibitors by measuring the competitive binding of red-shifted fluorescently labeled gel-danamycin (GM-cy3B) in NCI-N417 small-cell lung carcinoma cells. Since the publication of this article, Hsp90 has remained an attractive drug target for malignant tumors. Read, "High-Throughput Screening Fluorescence Polarization Assay for Tumor-Specific Hsp90," from the October 2007 issue of SLAS Discovery: https://lnkd.in/ezxK_CSK. #worldlungcancerday

Dive into a highly sensitive analysis using an EVOSEP-LC-MS/MS assay, with a focus on targeted PD-L1 and PD-1 expression levels to predict responses to immune checkpoint inhibitors (ICIs0) with this poster recently presented at #EBF. Learn about: 🔬The limitations of traditional PD-L1 and PD-1 immunoassays and their uncertain clinical value across tumor types. 🔬A new perspective on the predictive power of biomarkers for non-small cell lung cancer (NSCLC) therapy. Download the poster here: https://bit.ly/3RkTDbx #spatialbioanalysis #spatialbiology #cancer #evosep #immunoassays #assays

Check out this poster! #spatialbioanalysis #spatialbiology #cancer #immunoassay

Charles VOYTON, Senior Clinical Research Scientist, eyonis™, also presented a poster at the 2023 North America Conference on Lung Cancer (NACLC) on "End to End AI model for Nodule Detection and Characterization in Lung Cancer Screening: Performances and Subpopulation Analysis". The abstract presents the performances and subpopulation analysis of a computer-aided detection and characterization (CADe/CADx) AI model developed to aid lung cancer screening standard of care. Performance at nodule level in terms of AUC-ROC is 0.987, significantly outperforming the NLST Brock model (AUC-ROC 0.971). IASLC FOUNDATION #NACLC2023 Download the poster here: https://lnkd.in/e-hFVBh6

The proto-oncogene tyrosine-protein kinase-1 (Ros-1)-gene fusion is expressed in non-small cell lung cancer (NSCLC). The ROS1 Zeta-Antibody clone ZR400 readily assesses the ROS1 antigen as well as ROS1-fusion variants in lung cancer tissue.

🌐 Join our groundbreaking webinar with Leica Biosystems to explore the world of digital and quantitative multiplexed assays for protein and RNA tumor microenvironment profiling. 🔍 Pancreatic and colorectal cancers are among the deadliest in the U.S., but genomically-directed therapies help only a minority. The Wolpin-Nowak lab at Dana-Farber Cancer Institute is on a mission to change that. They aim to understand these deadly tumors better, detect them earlier, and develop innovative therapies. ➡️ Register here and learn the advantages of different assays and ensure high data quality, even with large-scale specimen analysis: https://buff.ly/45D7HRG #PancreaticCancer #Oncology #ColorectalCancer #MultiplexImmunofluorescence

Spatial transcriptomic profiling of tumors reveals the spatial context of tumor cells and their interactions with surrounding components like immune cells, stroma, and vasculature. Single-cell resolution is crucial for studying these dynamics. Download our poster presented by Dr. Cheng-Yi Chen, PhD at ASHG to learn how the Predesigned MERSCOPE Immuno-oncology Panel can be leveraged to examined cell subtype distribution and spatial dynamics in human lung cancer samples: https://lnkd.in/e_EGVz8n #ASHG23 #Vizgen #MERSCOPE #MERFISH #SpatialGenomics#LungCancer #Oncology #CancerResearch #SpatialData #DataAnalysis

Earlier this year, researchers in the Breast Cancer Now at the ICR discovered a new way to help prevent #BreastCancer ‘time bomb’. The team, led by the ICR’s Dean of Academic and Research Affairs, Professor Clare Isacke, showed that age-related changes in the level of a certain protein in the lung influence the development of secondary tumours in people with the most common type of breast cancer, oestrogen receptor positive (ER ) breast cancer. About four in five cases of primary breast cancer are ER , so future treatments that use this approach could benefit thousands of people by preventing the mechanism that causes dormant cancer cells to ’reawaken’. Read more about this ICR scientific achievement⬇️ https://lnkd.in/eK6aZR_a