#ArticleoftheWeek published by Nature Portfolio #Biotech #Organoids and organs-on-chips are transforming #drugdiscovery and #diseasemodeling by bridging the gap between 2D cultures and animal models. Read the latest review by Zhao et al., detailing their origins in #tissue engineering and regenerative #medicine, and highlighting recent #research adapting these technologies. #Applications include intestines, kidneys, lungs, liver, pancreas, brain, retina, heart, and tumors. Overcoming challenges like batch-to-batch variability and integrating vasculature will drive future innovations. Congratulations to: Yimu Zhao, Shira Landau, Sargol Okhovatian, Chuan (Mary) Liu, Rick Xing Ze Lu, Benjamin Fook Lun Lai, Qinghua Wu, Jennifer Kieda, Krisco Cheung, Shravanthi Rajasekar, PhD, Kimia Jozani, Boyang Zhang, Milica Radisic https://lnkd.in/e9SRuigh
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🔬 Excited to share my first blog post diving into the fascinating world of protein folding and Artificial Intelligence! In my blog, I give a basic introduction of the groundbreaking technology known as AlphaFold, revolutionizing biomedical sciences. Read how AI is transforming our understanding of protein structures and its implications for drug discovery and disease treatment. #Alphafold #Biomedical #ArtificialIntelligence https://lnkd.in/exCEjhQa
Introduction of Protein Folding using Artificial Intelligence
medium.com
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🔬 Exciting Developments in Drug Discovery! 🔍 At DrugSense Analytics, we're pioneering drug design with advanced docking simulations. Our computational techniques predict how small molecules (ligands) bind to target proteins, guiding precise interactions crucial for drug development. Leveraging AI and cutting-edge bioinformatics, we're accelerating the search for novel therapies. Join us in revolutionizing healthcare through innovative science. #DrugDiscovery #DockingSimulations #Bioinformatics #AIinHealthcare #InnovativeScience #drugsenseanalytics
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Lipid nanoparticles (LNPs) are versatile carriers with broad applications in drug delivery. LNPs deliver various payloads, including nucleic acids, small molecules, and proteins, across diverse therapeutic areas. By leveraging computational models and AI algorithms, at Prescience Insilico we are able to optimize LNP formulations by predicting drug interactions, loading, and release as a function of excipients and payloads. LNPs thus serve as a foundational technology in the intersection of biomedicine, computation, and AI, driving innovation in drug development and delivery. To know more, please contact us at [email protected] #drugdelivery #drugdesign #drugdevelopment #computationalbiology #insilicodrug
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3D imaging of organoid cultures offers a promising way to study complex mammalian tissues. This Biocompare article explores common challenges, recent advancements, and advice for researchers who want to image complex cell models better: https://ow.ly/JWoT50PZhVc. Joined by other industry experts from Agilent Technologies, Etaluma, Inc., and Corning Life Sciences, Oksana Sirenko, Ph.D., Senior Scientist at Molecular Devices, shares insights on how researchers are leveraging more advanced technologies such as automated high-content imaging platforms to better capture the depth of information that organoids offer. #3dbiology #AI #drugdiscovery #highcontentscreening #organoids #machinelearning
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Phenotypic analysis for automated cell culture and screening - High Content Imaging and organoids solutions for researchers - Organoids and PDO expansion/handling/screening - Sales and Business Development
Cellular models are becoming so complex that we see many research institute putting in place platforms dedicated to support researchers at producing those cells (IPSC - 3D models). The models of the future capturing the complexity of biology need to be mastered to be a consitent tool. ✔️Need to analyse 24/24 your cells, in order not to miss the right moment ✔️Need an operator independant choice to have the best reproducibility We created a new tool for scientists, enabling a 24/24, 7/7 fully automated and reproductible culture. Empowered with our imaging and machine learning tools, to capture and analyze complex phenotypes enabling consistent and unbiased cell processing. All the info => https://lnkd.in/eUn9c7rb Molecular Devices #RemoveTheBias #IPSC #organoid #MachineLearning #CellCultureOfTheFuture
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Scientists are thinking about whether AI can use small lab-grown organs instead of computers to work better, by copying structures similar to brains. They call this Organoid Intelligence. Artificial Intelligence is getting a lot of attention as a big technological change right now. But Organoid Intelligence might push AI even more. #LabTissue #Organoid #Intelligence #Biotechnology #Engineering #Tech #Scitke
Breakthrough in Organoid Intelligence
https://scitke.com
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Although it sounds like a science fiction scenario, scientists have managed to build robots from human cells! What's more, they can heal people!🥼😮 Microscopic biological robots (called Anthrobots) made of human cells move and can heal wounds and repair damaged tissues. American scientists announced this breakthrough discovery on the Harvard University website.🔬 Anthrobots were grown from mature tracheal epithelial cells. Why were tracheal cells chosen? Among other things, they are equipped with waving cilia, usually used to remove various contaminants and dust particles from the respiratory tract. Scientists explain that they relatively quickly form into so-called organoids, i.e., cell formations used for research. The most exciting thing about this achievement was the observation that wandering anthrobots can regenerate damaged tissue when they encounter it. This was demonstrated by an experiment in which scientists placed anthrobots on damaged neurons. Therapies using anthrobots are only plans for now, requiring further extensive research and experiments. However, the achievements of scientists so far give hope that they will be able to develop them in the desired direction. Clinmark is fascinated with development of medicine and pharmaceutical market and we are happy to be a part of it!🤓 #clinmark #clinicaltrials #breakingnews #Anthrobots #breakthrough #medicine #hope
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#BioImaging | 𝗛𝗼𝘄 𝗥𝗲𝗱 𝗕𝗹𝗼𝗼𝗱 𝗖𝗲𝗹𝗹𝘀 𝗗𝗲𝗳𝗼𝗿𝗺 | Empa researcher Dr. Peter Nirmalraj has made a significant breakthrough in the field of bio-imaging. His team has effectively used holotomographic microscopy to study drug molecules' interaction with the cell membrane on red blood cells. The study witnessed a real-time transformation of living red blood cells into spiky "echinocytes" when treated with high concentrations of ibuprofen. This outstanding scientific achievement, powered by digital holotomographic microscopy, generated high-resolution, non-contact, marker-free images converted into three-dimensional representations. The importance of this research lies in its unprecedented insights into how drug molecules interact with cell membranes. Moreover, the technique sheds light on the impact of various chemical and physical environments on red blood cells, contributing significantly to expanding our understanding in the bio-imaging field. 👉 Learn more >> https://lnkd.in/gZKGnaF3 👉 Original publication >> https://lnkd.in/gUwXHtft 🇨🇭 Follow #ScienceSwitzerland for the latest news and emerging trends on Swiss science, technology, education, and innovation >> www.swissinnovation.org Follow us >> Science-Switzerland #Science | #Education | #Research | #Innovation
Spiky insight: How red blood cells deform
empa.ch
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