Cellbox Solutions’ Post

Aging-associated stress triggers senescence in neurons Early in life, neurons differentiate terminally from neural stem cells, followed by a permanent halt in their cell cycle. This irreversible arrest exposes them to a lifetime of age-related stress, ultimately leading to a subpopulation of senescent neurons in late life. Interestingly, despite their inability to proliferate, these senescent neurons exhibit other hallmarks typically associated with senescence. This great perspective article published in Science: https://lnkd.in/ekHSKHzF #genetics #genomics #precisionmedicine #genomicmedicine #epigenetics #epigenomics #brain #neurology #neuroscience #neurodegeneration #aging #longevity #inflammation #autophagy #preliferation #immunity #biomarkers #biotechnology #innovation #research #science #sciencecommunication

A novel oligodendrocyte, immune oligodendroglia (imOLG), expresses genes associated with immune function and is more prevalent in Multiple Sclerosis (MS) lesions compared to normal-appearing white matter (NAWM). The presence of imOLGs suggests a potential link between immune dysregulation and oligodendrocyte dysfunction in MS. A great study by Sarah Jäkel, et al. on Nature “Altered human oligodendrocyte heterogeneity in multiple sclerosis” #Oligodendrocytes #imOLG #MultipleSclerosis #Neuroscience #MyelinRepair #TherapeuticTargets #snRNA #BioTuring Read the publication here: https://lnkd.in/g3tP_gTX Explore the dataset on Talk2Data now: https://lnkd.in/gUN7bXzt

April is Parkinson’s Awareness Month, and we’d like to recognize all of the hard work and research that has generated a better understanding of the disease and what we can do to treat it. Advancing technologies are helping accelerate the pace at which new therapies are developed, with multiplexed imaging becoming integral to these efforts by revealing the spatial distribution of key proteins in neural tissues. Check out some of this research on Parkinson’s disease and other neurodegenerative disorders: https://lnkd.in/giECekUW Explore the #ABCsofPD from the Parkinson’s Foundation to learn more about the complexity of Parkinson’s disease and recognize its symptoms: https://lnkd.in/gEnv-gX #Parkinsonsdisease #neuroscience #neurodegeneration

What if a tiny mutation could push brain cells in opposite directions? 🧠 New findings published in Cell Reports explain how Slack potassium channel mutations can ramp up activity in excitatory neurons while quieting inhibitory ones. This surprising dual effect, explored through a combination of detailed immunoassays and delicate electrophysiology that use anti-NaV antibodies and tetrodotoxin from Alomone Labs, offers a fresh perspective on epilepsy and intellectual disabilities. The study dives into the molecular tweaks that alter sodium and potassium currents, revealing a deeper narrative about how our brains manage communication among neurons. With potential paths to novel treatments, understanding these mutations could lead to major advances in neuroscience. Come and learn more about the brain’s balancing act and its implications for #epilepsy: https://lnkd.in/e5YkjR_H #epilepsy #neuroscience #immunoassays #electrophysiology  Cell Press Jing Wu Imran Quraishi Mark Bromwich Leonard Kaczmarek Yale University Yale School of Medicine

Exciting breakthrough: Scientists have created the first 3D brain organoids using cells from multiple human donors, paving the way for personalized medicine and better understanding of brain development. 🔬 Revolutionizing neuroscience with diverse genetic insights 🧠 Simulating broad genetic diversity for accurate predictions 💊 Enhancing drug response predictions for personalized treatments #Neuroscience #PersonalizedMedicine #Innovation 📊 Combining cells from up to five donors for diverse models 📈 Potential to revolutionize drug development and testing 🔍 Detailed study led by Harvard's Paola Arlotta 🧩 Understanding individual brain development variations These 3D model brains with cells from several people are first of their kind https://lnkd.in/gNfms9zu

🔋 Batteries of the brain: mitochondria in human iPSC-astrocytes. 🧠 There is a significant unmet need for #DrugDiscovery across the spectrum of central nervous system disorders. Advances in human iPSC cell models, #biomarker research techniques, and a new understanding of the contribution of the immune system have led to a renewed interest in #neuroscience drug discovery. 🔗 https://hubs.li/Q02r0--K0

Tanycytes are specialized radial astrocytes. In their latest study, published in Nature (PMID: 38538787), Benevento et al. did not only show that tanycytes are synaptically modulated, but defined a multimodal neurocircuit in which tanycytes link a primary sensory modality to metabolic changes. In their interesting experimental approach, they especially used our SYSY antibody against Vimentin (chicken no. 172 006). Further SYSY antibodies used are antibodies against cFos (guinea-pig no. 226 005 and rabbit no. 226 003) and VGLUT2 (guinea-pig no. 135 404 and rabbit no. 135 403). www.sysy.com https://lnkd.in/eAn_9TbV #neuroscience #antibody #Vimentin #cFos #VGLUT #immunohistochemistry #electronmicroscopy

Researchers discovered that 'pan-glial' activation, characterized by an increased number and activity of microglia and astrocytes, functions as a central mechanism in the pathogenesis of Parkinson's disease. Additionally, they identified a unique neuronal cluster expressing high CADPS2 and low TH. These findings suggest the potential for developing specific therapies targeting neuroinflammation in Parkinson's disease. A fascinating study by Smajić et al. “Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state”. #parkinsondisease #PD #midbrain #microglia #astrocyte #neuroglia #neuroinflammation #neuroscience #snRNA #snRNAseq #BioTuring Read the publication here: https://lnkd.in/gBxWiCFs Explore the dataset on Talk2Data now: https://lnkd.in/gFaV9Djz