Second Nature’s Post

It is becoming increasing obvious that if our tissue CLOCKS get out of synchronization with our central CLOCK (SCN) then things get wonky. It doesn't really matter the disease, if you look deep enough you will find CLOCK disruptions. Diabetes, obesity, and really all of metabolic syndrome show CLOCK disruptions between the SCN and peripheral tissues. Would reseting the clock be enough to reset these dysregulations? There is no question that CLOCK must be worked into ANY effective drug design. In fact dosage times with drugs that are trying to get in the middle of this will be super duper important. "Sleep and circadian disruption are associated with an increased risk of metabolic disease, including obesity and diabetes. Mounting evidence indicates that misaligned and/or non-functional clock proteins in peripheral tissues critically contribute to the presentation of metabolic disease." https://lnkd.in/gGQSXXTM

Do you know what causes Dercum’s Disease? 🔍 The exact catapult of Dercum’s Disease remains unknown, though it is believed to involve genetic, autoimmune, and metabolic factors. Risk factors include age (most common in middle-aged individuals), sex (predominantly affects women), and obesity. Dercum’s is characterized by the growth of multiple lipomas. These benign fatty tumors are generally classified into three categories: ✨Nodular: Large lipomas around the back, abdomen, thighs, and arms ✨Diffuse: Widespread presence of small lipomas ✨Mixed: A combination of both small and large lipomas in various areas of the body Currently, there is no standard diagnostic process for Dercum’s Disease. To determine if Dercum’s lipomas are present, you can schedule a consultation with Dr. Schwartz or Dr. West for a thorough examination. Stay informed and take control of your health. Book your consultation today at 888-LIPEDEMA! 📞 https://bit.ly/3zmqmXa #dercumsdisease #totallipedemacare #beverlyhillsplasticsurgeron

TYG INDEX - THE TWO VALUES. TyG index is becoming an increasingly important parameter for predicting the development of many systemic diseases. Unfortunately, it is expressed as 2 different formulas in papers. The correct formula is: ln [fasting trygliceride (mg/dl) x fasting glucose (mg/dl)]/2 The "uncorrect" formula is: ln [fasting trygliceride (mg/dl) x fasting glucose (mg/dl)/2] This difference generates confusion and difficulties in comparing data. Hoping to do something useful, here below a conversion table of the TyG index calculated with the two values, divided into quartiles, and based on parameters taken from the following paper: https://rdcu.be/dnMGb Q1. 4.30 corresponds to 7.91 Q2. 4.54 corresponds to 8.39 Q3. 4.73 corresponds to 8.77 Q4. 5.03 corresponds to 9.37

I cannot stop looking on this amazing database! So exciting to see where #aging field is developing! Targeting aging is targeting modern diseases GLP1 agonists, SGLT2i,… are showing great anti aging effects: https://lnkd.in/d4QVP2M3 Please feel to share your thoughts and your 💡 #cardiometabolic #aging #diabetes

❗️Dyslipidemia and hypercholesterolemia are global health issues that require urgent and efficient treatments due to their major impact on cardiovascular disease. ❗️The incidence of these illnesses is impacted by population and time differences, with familial hypercholesterolemia and lifestyle changes exacerbating these disorders. 🧬Inclisiran, a recently licensed RNA interference therapy, specifically a proprotein convertase subtilisin/ kexin type 9 siRNA inhibitor, appears to be a revolutionary treatment method. 🔍However, questions about its long-term safety, impact on lipid metabolism, and cost-effectiveness remain unanswered. For more information, check this review from our latest issue!

Listening to a podcast in the gym the other day and this was discussed. Worth a read or a listen! How do our muscles respond at the molecular level to exercise? Novel insights are paving the path towards precision medicines targeting metabolic disorders like obesity and diabetes, as well as muscle-related illnesses. These new findings can additionally offer a possible mechanistic explanation as to why anti-inflammatory treatment targeting IL6R has been associated with the development of muscle weakness as a side effect in the clinic. https://lnkd.in/e7Z_tRf3

It's essential to acknowledge the multifaceted role of estrogen in male physiology so that you can continue to work hard and stay healthy. Randomized controlled trials do not support lowering estrogen (studies that support this are observational and do not prove causation). In randomized control trials when we give testosterone (in turn increase in estrogen via aromatization) we see decrease heart disease, diabetes, and visceral fat.                                                                                                               —- Studies continued in the comments section.

“Mild chronic inflammation is generally considered to be a biomarker of accelerated biological ageing or one of the mechanisms by which the ageing process is associated with increased global susceptibility to all diseases.” (NIH) In awareness of the fact that with the simple measurement of C-reactive protein (CRP) we already have an indication of ongoing inflammatory processes, Bloom Diagnostics developed the Bloom Inflammation Test. It helps track inflammations in general, as well as inflammatory processes caused by overweight, and also the process of ageing. A simple test that says so much. It is non-specific, however, the developed algorithms and ML implemented by Bloom help patients with real-time feedback on the status and next steps needed. A simple prick for so much information. #overweight #ageing #inflammation #trackinghealth #GLP1

Even small amounts of toxic ingredients in skin products can add up and contribute to endocrine disorders, heart disease, cancer, and a range of other illnesses.⁠ ⁠ In a recent episode of The Doctor’s Farmacy, I spoke to Dr. Cindy Geyer about why it’s important to take a good look at what we put on our skin. We also discussed the dangers of ingredients such as parabens and phthalates, which can disrupt hormones, as well as how I detox my body, where to find out how safe your favorite products are, and much more.⁠ ⁠ Take a listen here: https://bit.ly/3AP4yPM

Numerous studies have demonstrated a strong association between gut dysfunction and Parkinson's disease (PD), with differences in gut microbiota composition in patients with PD a common finding. One key finding is that colonic inflammation is identified in over 80% of PD cases and precedes the motor symptoms even by several years. #PD #Parkinsons #parkinsonsdiseas #neurodegernative #microbiota #microbiome #gutmicrobiome