Allen Institute’s Post

Read all about our latest study by Harmke Duindam and Wilson Farid Abdo 🌱 and others from IC Research Radboudumc and colleagues from the University of Tübingen on neuroinflammation and neuro-axonal damage in relation to cognitive outcome after severe COVID-19. Here, advanced analyses were performed in a group of 96 critically ill COVID-19 patients to measure levels of inflammatory cytokines and neurofilament light chain (NfL), using an ultrasensitive multiplex Luminex assay and single molecule array technique. We demonstrated that patients with a higher plasma NfL during their stay at the intensive care unit (ICU) were more likely to develop cognitive impairment six months after their discharge. Also, the mechanism from systemic inflammation via neuroinflammation and axonal damage to cognitive impairment is presented. The current study provides important insights into the neural mechanisms of cognitive impairment in severely ill COVID-19 patients. It should be noted that our current sample of critically ill COVID-19 patients who were treated at the ICU is not representative of the larger population of long COVID patients who experience persistent symptoms, of whom many have never been hospitalised. The paper is published in 'Brain, Behavior, and Immunity', see the link below. #clinicalneuropsychology #neuroinflammation #covid19 #sarscov2

Our latest paper in Brain Behavior Immunity on the role of systemic inflammation in cognitive decline in humans. Key finding --> systemic inflammation during severe COVID-19 disease was linked to neuroaxonal damage, which was associated with cognitive decline 6 months afterwards!! Special thanks to Harmke Duindam who as the PhD student did the most work, together with David Mengel. This work was a collaborative effort between our IC Research Radboudumc, prof Roy P.C. Kessels and Prof Matthis Synofzik group at the German Center for Neurodegenerative Diseases (DZNE) in Universitätsklinikum Tübingen #brainaging, #neuroinflammation, #inflammaging, #COVID19, #longCOVID, #cognition https://lnkd.in/exVUnm38

What is Multiple Sclerosis (MS)? Sandhya Misra, Patient Journey Partner, Neuroscience, at Roche South Africa and Leeverne Engelbrecht, Patient Journey Partner at Roche South Africa, explain this often-misunderstood disease in 40 seconds. #MS #MultipleSclerosis #UnderstandingMS #Roche #RocheAfrica

Memory loss is one of the most devastating effects of Alzheimer's disease. Dr. Yingxue Wang is leading a new charge to understand how the brain forms memories, stores them, and why they deteriorate with Alzheimer's disease. Funded by a 3-year, $1M award from the National Institute on Aging of the NIH, Dr. Wang will investigate how cholinergic functional decline impacts the hippocampus - a region of the brain that is crucial in turning daily experiences into memories. https://lnkd.in/gT4r5P3P #AlzheimersResearch #NeuroscienceResearch #BrainResearch #Memories

Next week, Reykjavik University will organise the NeurotechEU Symposium on "Towards Transdisciplinarity in the Investigation of Neurological Diseases". A significant future challenge for Europe lies in the escalating prevalence of neurological diseases across the lifespan. Despite their widespread impact, our understanding of neurological disease mechanisms is still lacking. Thus, effective treatments remain elusive, imposing profound and adverse consequences on patients, their families, and society at large. This symposium offers a glimpse into the diverse research endeavours undertaken by NeurotechEU participants, driven by both interdisciplinary and transdisciplinary ambitions. #NeurotechEUsymposium #neurotech https://buff.ly/4bQva5p

Researchers from the University of Florida have found an association between abnormal amyloid levels in the blood and structural abnormalities in the brain that could contribute to Alzheimer's disease. 🧠 The team used diffusion MRI, or "free-water imaging", to detect early stages of decline in brain tissue and recognize tiny structures in critical parts of the brain. These detections sometimes occured even when the PET scan was negative. ❌ DAVID VAILLANCOURT, Ph.D., of UF College of Public Health and Health Professions said these results have changed how experts think about the disease. 🔬 Learn more about the findings, here. ▶️ https://lnkd.in/eGeJ9KHi

Focused ultrasound potential is massive!

Groundbreaking research from the Mayo Clinic, Newcastle University, and the University of Glasgow has unveiled a tantalizing link between aging and dying mitochondria. These tiny powerhouses, when they burst, accelerate cellular aging. Remarkably, treating old mice with drugs that prevent this bursting rejuvenated their health, reducing brain inflammation and improving mobility and bone strength. Could this be the first step towards our own fountain of youth? Dive into this fascinating study and discover how the dream of living longer, healthier lives might soon become a reality! https://lnkd.in/dXGh82nZ

A diagnosis for #AlzheimersDisease involves a combination of neurological exams, brain imaging, and genetic and cognitive testing. Women have been shown to perform better on certain verbal memory tests and are more likely to sustain cognitive function longer. As a result, women tend to receive an Alzheimer’s disease diagnosis later, with a more severe disease burden and faster cognitive decline. Learn more in SWHR's Breaking Barriers in Alzheimer’s Disease webinar series: https://ow.ly/AmLw50S2uuK The next event is coming up on June 21! #SWHRtalksAlzheimers #AlzheimersAndBrainHealthAwarenessMonth

🌟 Discover the Highly Cited Article: Unveiling Breakthroughs in Neurodegenerative Disease Research! 🧠🔬Dive into the realms of cutting-edge science with our high-impact publication in neurodegenerative disease research. 📖 Article Title: Tau-targeting therapy in Alzheimer's disease: critical advances and future opportunities 🔗 Read the Full Article: https://lnkd.in/eBPcErxZ Key Highlights: 🧪 Revolutionary Discoveries: Explore groundbreaking findings that are shaping the future of neurodegenerative disease understanding. 🌐 Global Impact: This research transcends borders, with implications for patients and scientists worldwide. Join the scientific conversation, stay informed, and be part of the change. Don't miss out on this opportunity to engage with pioneering research that's making a real difference. #NeurodegenerativeResearch #ScientificBreakthroughs