Vinod Vathipadiekal

Vinod Vathipadiekal

Boston, Massachusetts, United States
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Experience

  • Alloy Therapeutics, Inc. Graphic

    Alloy Therapeutics, Inc.

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    Boston, Massachusetts, United States

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    Boston, Massachusetts, United States

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    Cambridge, MA

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    Boston

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    Greater Boston Area

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    Bethesda

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Education

Publications

  • Overcoming adaptive resistance to anti-VEGF therapy by targeting CD5L

    Nat Commun . 2023 Apr 26;14(1):2407. doi: 10.1038/s41467-023-36910-5

  • Stereochemistry Enhances Potency, Efficacy, and Durability of Malat1 Antisense Oligonucleotides In Vitro and In Vivo in Multiple Species

    Transl Vis Sci Technol .

  • Stereopure oligonucleotides achieve allele-selective reduction of P23H mutant rhodopsin

    Investigative Ophthalmology & Visual Science

  • Stereopure oligonucleotides promote USH2A exon skipping for the treatment of Usher syndrome type 2A

    Investigative Ophthalmology & Visual Science

  • Stereochemistry enhances pharmacological properties of APOC3 antisense oligonucleotides

    Journal of Hepatology

  • A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia.

    Am J Hematol.

  • Homozygosity for a haplotype in the HBG2-OR51B4 region is exclusive to Arab-Indian haplotype sickle cell anemia.

    Am J Hematol.

  • Polymorphisms Associated with the Arab-Indian Haplotype of Sickle Cell Anemia Are Candidate Fetal Hemoglobin Gene Modulators

    Blood

  • AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer

    Proc Natl Acad Sci U S A.

  • BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia.

    Blood Cells Mol Dis.

  • Comparing Platforms for Messenger RNA Expression Profiling of Archival Formalin-Fixed, Paraffin-Embedded Tissues.

    J Mol Diagn.

  • Creation of a Human Secretome: A Novel Composite Library of Human Secreted Proteins: Validation Using Ovarian Cancer Gene Expression Data and a Virtual Secretome Array.

    Clin Cancer Res.

  • Identification of LMX1B as a novel oncogene in human ovarian cancer.

    Oncogene

  • Selumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: an open-label, single-arm, phase 2 study.

    Lancet Oncol.

  • Low-grade and high-grade serous Mullerian carcinoma: review and analysis of publicly available gene expression profiles.

    Gynecol Oncol.

  • Ovarian cancer: genomic analysis.

    Ann Oncol.

  • ANGIOGENESIS, METASTASIS, AND THE CELLULAR MICROENVIRONMENT

    Journal of the Molecular and Cellular Biology of Cancer

  • ALDH1A1 is a novel EZH2 target gene in epithelial ovarian cancer identified by genome-wide approaches.

    Cancer Prev Res (Phila).

  • An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer.

    PLoS One

  • Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses

    J Immunol.

  • Identification of a Potential Ovarian Cancer Stem Cell Gene Expression Profile from Advanced Stage Papillary Serous Ovarian Cancer.

    PLoS One

  • SUZ12 promotes human epithelial ovarian cancer by suppressing apoptosis via silencing HRK

    Mol Cancer Res

  • Identification of Novel Therapeutic Targets in Microdissected Clear Cell Ovarian Cancers

    PLoS ONE

  • Inhibition of Hedgehog signaling antagonizes serous ovarian cancer growth in a primary xenograft model.

    PLoS One

  • Molecular cloning, over expression, and activity studies of a peptidic HIV-1 protease inhibitor: Designed synthetic gene to functional recombinant peptide.

    Peptides

  • A gene signature predictive for outcome in advanced ovarian cancer identifies a novel survival factor: microfibril-associated glycoprotein 2.

    Cancer Cell

  • Fabrication, Characterization and Biocatalytic activity of Fungal Protease-Nanogold Membrane Bioconjugate.

    J. Nanosci. Nanotechnol.

  • Glycine Assisted Enhancement of 1, 4, beta D Xylan Xylanohydrolase Activity at Alkaline pH with a Shift in pH Optimum.

    Biol. Chem.

  • Intact cell matrix-assisted laser dissociation/ionization mass spectrometry as a tool to screen drugs in vivo for regulation of protein expression.

    Rapid Commun. Mass Spectrom.

  • Preparation and Characterization of Urea-Formaldehyde-Pepsin Bioconjugate: A new biocatalyst system.

    Biotechnol. Progr.

  • Beta-Secretase: A potential therapeutic target in Alzheimer’s disease.

    Adv. Biotech

  • Free standing gold membranes as scaffolds for enzyme immobilization.

    Langmuir.

  • Immobilization and Biocatalytic Activity of Fungal Protease on Gold Nanoparticle-Loaded Zeolite Microspheres.

    Biotech. Bioeng.

  • Inhibition of 1,4 -- D Xylan Xylanohydrolase by the Specific Aspartic Protease Inhibitor Pepstatin: Probing the Two-step Inhibition Mechanism.

    J. Biol. Chem.

  • Direct assembly of gold nanoparticle “shells” on polyurethrene microsphere “cores” and their application as enzyme immobilization templates

    Chem. Mater.

  • Gold Nanoparticles Assembled on Amine-Functionalized Na-Y Zeolite: A Biocompatible Surface for Enzyme Immobilization.

    Langmuir.

  • Improved performance of preordered fungal protease stearic acid biocomposites: enhanced catalytic activity, reusability and temporal stability.

    Biotechnol. Progr.

  • Slow-tight binding inhibition of Xylanase by an aspartic protease inhibitor: kinetic parameters and conformational changes that determine the affinity and selectivity of the bifunctional nature of the inhibitor.

    J. Biol. Chem.

Patents

  • Phasing

    Issued US WO2018022473

    Phasing of allelic variants of genetic loci on an individual patient's chromosomes is highly valuable for many purposes, including patient stratification for allele-specific therapeutics

    Other inventors

  • Antisense oligonucleotides and their use for treatment of neurodegenerative disorders

    US WO2022232411

  • DOUBLE STRANDED OLIGONUCLEOTIDE COMPOSITIONS AND METHODS RELATING THERETO

    US WO2021234459

  • Methods and compositions for targeting efemp1

    WO2023154964

  • Oligonucleotide compositions and methods of use thereof

    US WO2018223056

  • Oligonucleotide compositions and methods of use thereof (APOC3)

    US WO2018223073

  • Oligonucleotide compositions and methods of use thereof (PNPLA3)

    US WO2018223081

  • Oligonucleotide compositions and methods of use thereof (Rho P23H)

    US WO2020219983A2

  • Oligonucleotide compositions and methods of use thereof (USH2A)

    US WO2020219981

  • Peptide-antisense oligonucleotides and their use for treatment of neurodegenerative disorders

    US WO2024092256A2

Honors & Awards

  • AACR 2012 Annual Meeting "Highly Rated Paper”

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  • American Society of Hematology, Abstract Achievement Award

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  • Travel Award to attend "20th IUBMB International Congress of Biochemistry and Molecular Biology, Kyoto, Japan

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  • “AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award”

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  • “Best Poster Award” in the 2nd National Conference of the BSI, New Delhi, India

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  • “Best Research Paper Award” from National Chemical Laboratory, Pune, India

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  • “Best Research Scholar Award” from National Chemical Laboratory, India.

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  • “Department of Science and Technology Award” to represent India in the 55th meeting of Nobel Laureates and Students in Lindau, Germany.

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  • “Deutsche Forschungsgemeinschaft" Germany invited to visit various research institutes in Germany working in the area of Biology/ Medicine, Germany.

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  • “IUBMB Young Scientists Award” from International Union of Biochemistry and Molecular Biology

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  • “Poster of Distinction Award” ECOR, Boston, MA, USA

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  • “von der Luft Award for Ovarian Cancer Research" MGH Cancer Center

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Languages

  • English

    Native or bilingual proficiency

  • Hindi

    Full professional proficiency

  • Malayalam

    Native or bilingual proficiency

  • Tamil

    Full professional proficiency

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