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Polyethylene Glycol Coatings on Plastic Substrates for Chemically Defined Stem Cell Culture
Advanced Healthcare Materials
Human mesenchymal stem cells (hMSCs) are a widely available and clinically relevant cell type with a host of applications in regenerative medicine. Current clinical expansion methods can lead to selective changes in hMSC phenotype potentially resulting from relatively undefi ned cell culture surfaces. Chemically defi ned synthetic surfaces can aid in understanding the infl uence of cell–ma-terial interactions on stem cell behavior. Here, a thin copolymer coating for hMSC culture on plastic…
Human mesenchymal stem cells (hMSCs) are a widely available and clinically relevant cell type with a host of applications in regenerative medicine. Current clinical expansion methods can lead to selective changes in hMSC phenotype potentially resulting from relatively undefi ned cell culture surfaces. Chemically defi ned synthetic surfaces can aid in understanding the infl uence of cell–ma-terial interactions on stem cell behavior. Here, a thin copolymer coating for hMSC culture on plastic substrates is developed. The random copolymer is synthesized by living free radical polymerization and characterized in solu-tion before application to the substrate, ensuring a homogeneous coating and limiting the sample-to-sample variations. The ability to coat multiple substrate types and cover large surface areas is reported. Arg–Gly–Asp-containing peptides are incorporated into the coating under aqueous conditions via their lysine or cysteine side chains, resulting in amide and thioester linkages, respec-tively. Stability studies show amide linkages to be stable and thioester linkages to be labile under standard serum-containing culture conditions. In addition, chemically defi ned passaging of hMSCs using only ethylenediaminetetraacetic acid on polystyrene dishes is shown. After passage, the hMSCs can be seeded back onto the same plate, indicating potential reusability of the coating.
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Shadow Elections
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Shadow Elections is a collaboration between graduate students from NYU’s Studio 20 and Parsons School of Art, Media and Technology, and Fusion—a media company striving to listen to and elevate the voices of those who too often aren’t heard. The project aims to capture the voices and opinions of individuals who are largely impacted by the upcoming US presidential election, but ineligible to vote, as a basis for journalism and visualization on ShadowElections.com and Fusion.net.
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Persian
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Italian
Elementary proficiency
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German
Limited working proficiency
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English
Native or bilingual proficiency
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Danny Williams
What makes a story or presentation great? Earlier this year, I sat down with the Stripe design team to share my advice on creating effective presentations and telling engaging stories. Here’s what I shared with the team: 👇 Creating engaging presentations involves two steps: 1️⃣ Building structure 2️⃣ Adding detail -- Step 1️⃣: Building structure -- 🤨 → Start with why–Understand why your presentation exists. What are you trying to achieve? Are you explaining, motivating, or convincing? Who is your audience? ✍️ → Write it out—Writing a script helps you quickly outline possible structures and keeps the focus on the content that best meets your presentation’s purpose. 🎨 → Draw it out—If writing isn’t working, try drawing! Think about key visuals or concepts you want to convey. Sketch those out in logical order. 🔬 → Avoid jumping into detail—Add detail only when your structure can support it. Otherwise, you'll get bogged down in unnecessary content—a common issue for new designers. 📐 → Use a blueprint—If you’re struggling, use familiar story structures like Rags to Riches, Hero’s Journey, or Elevator Pitch. ⚔️ → Define your timelines and tensions—Across any good story are clear timelines and tensions. Ask yourself “what are the key events or moments of tension in my story?” Build off those. -- 2️⃣ Adding detail -- 🖱️ → Keep it simple—Simplicity helps your audience understand your message. And that's the ultimate goal. 🎯 → One thing at a time—Avoid overloading slides with information. Present concepts, images, and data points one at a time to help your audience absorb the material. 🤔 → Fidelity dictates feedback—Use a level of fidelity that reflects the feedback you want. Higher fidelity tends to prompt detailed feedback, while lower fidelity focuses on overall structure and flow. 🧑🔬 → Ditch the jargon—Avoid using technical jargon and acronyms without explanation. It can confuse your audience and distract from your message. Meet them at their level of understanding. 🛠️ → Make it real—Use real-world examples to help your audience visualize the context of your presentation. On the other hand, using 'lorem ipsum' in your designs can make it challenging for your audience to provide useful feedback and critique. That's it! I hope these tips help you create and present your work with greater confidence. If you'd like to see the full presentation or share your tips, let me know in the comments below! 👇 #storytelling #design
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Akhil Patel
The design job market is tough right now (for new and experienced folks alike). I've had many people reach out to me for advice to whom I've always replied that my journey has been far from perfect. I've had my fair share of failures (& some successes) as a designer and I'm happy to share the lessons I've learned along the way. If you or someone you know wants to talk about anything design (portfolio, interviews, layoffs, team fit, rejections, product feedback, etc.), I'm happy to chat. :) #productdesign #adplist #mentorship
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Maggie Chen
There’s a subtle difference between “educating” stakeholders and making the impact of your work visible. One of these can help you win promotions, autonomy, and co-conspirators. The other can distract you from your craft at best… or devalue your work at worst. Thought-provoking article from Sara Wachter-Boettcher on how designers can reframe “advocating for design” in a way that avoids burnout and sidesteps the gaslighting.
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Halli Beaudoin
PART I I'm curious how other UX/ Product designers feel about the flow of the new Apple California drivers license app? It has to be usable to millions of people, a huge spectrum of ages and varying tech skills. #AppleWallet #CaliforniaDMV #DigitalID #MobileDriversLicense #ApplePay #PrivacyAndSecurity #TechInnovation #DigitalTransformation #AppleWatch #iPhone16 #DMVPilotProgram #MobileID #SecureIdentity #InnovationInTech #GovTech #SmartWallet #FutureOfIdentity #TechNews #DigitalPrivacy #AppleUpdates https://lnkd.in/g_buWapY
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