About
Board-certified clinical, anatomic and molecular genetic pathologist, sub-specialized in…
Activity
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Dr. Kevin Contrera interviews Dr. Stephen Lai on NRG Oncology Trial HN006: Randomized phase II/III Trial of Sentinel Lymph Node Biopsy Versus…
Dr. Kevin Contrera interviews Dr. Stephen Lai on NRG Oncology Trial HN006: Randomized phase II/III Trial of Sentinel Lymph Node Biopsy Versus…
Liked by Paolo Cotzia
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Huzzah! While our EPISEEK Screening test is already in market, we are developing Diagnostic use cases for liquid biopsy as well. Check out…
Huzzah! While our EPISEEK Screening test is already in market, we are developing Diagnostic use cases for liquid biopsy as well. Check out…
Liked by Paolo Cotzia
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🚀Exciting news to share 🚀 PanTher Therapeutics received the “Study May Proceed” letter as FDA clears our IND for the PTM-101 phase 1b pancreatic…
🚀Exciting news to share 🚀 PanTher Therapeutics received the “Study May Proceed” letter as FDA clears our IND for the PTM-101 phase 1b pancreatic…
Liked by Paolo Cotzia
Experience
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Education
Licenses & Certifications
Publications
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NTRK Fusions Define a Novel Uterine Sarcoma Subtype With Features of Fibrosarcoma.
Am J Surg Pathol
See publicationNTRK fusion-positive uterine spindle cell sarcomas constitute a novel tumor type with features of fibrosarcoma; patients with these tumors may benefit from Trk inhibition. TrkA and pan-Trk expression in leiomyosarcomas is rare and does not correlate with NTRK rearrangement.
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Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment.
Semin Oncol
Aggressive cHL exhibits features of metabolic heterogeneity with high mitochondrial metabolism in cancer cells and high glycolysis in TAMs, which is not seen in reactive lymph nodes. Future studies will need to confirm the value of these markers as prognostic and predictive biomarkers in clinical practice. Treatment intensity may be tailored in the future to the metabolic profile of the tumor microenvironment and drugs that target metabolic heterogeneity may be valuable in this disease.
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Pilot study demonstrating metabolic and anti-proliferative effects of in vivo anti-oxidant supplementation with N-Acetylcysteine in Breast Cancer.
Semin Oncol
NAC as a single agent reduces MCT4 stromal expression, which is a marker of glycolysis in breast cancer with reduced carcinoma cell proliferation. This study suggests that modulating metabolism in the tumor microenvironment has the potential to impact breast cancer proliferation.
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Languages
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English
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Italian
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Organizations
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American Society of Investigative Pathology
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- Present -
American Society for Clinical Pathology
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College of American Pathologist
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United States and Canadian Academy of Pathology
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Pathology Society of Philadelphia
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- Present
More activity by Paolo
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TSH suppression in intermediate- and high-risk differentiated thyroid cancer may not improve survival but increases risk of complications. Watch:…
TSH suppression in intermediate- and high-risk differentiated thyroid cancer may not improve survival but increases risk of complications. Watch:…
Liked by Paolo Cotzia
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🦋 PDL1 in anaplastic #thyroid cancer 📍 #ECP2024 #Florence #pathology #cancer #endocrinology #biopsy #surgery #medicine
🦋 PDL1 in anaplastic #thyroid cancer 📍 #ECP2024 #Florence #pathology #cancer #endocrinology #biopsy #surgery #medicine
Liked by Paolo Cotzia
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Can the intersection between #TSH and genetics lead to more individualized #thyroid references ranges? New data in the Thyroid Journal reviewed by…
Can the intersection between #TSH and genetics lead to more individualized #thyroid references ranges? New data in the Thyroid Journal reviewed by…
Liked by Paolo Cotzia
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My T.E.A.M.s paper on WES and introduction of AUGMET, our internal analytics pipeline, was recently published in the Journal of Molecular…
My T.E.A.M.s paper on WES and introduction of AUGMET, our internal analytics pipeline, was recently published in the Journal of Molecular…
Liked by Paolo Cotzia
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Student and alumni athletes from UT institutions claimed an impressive 21 medals at the 2024 Paris Games – including nine gold. If the UT System were…
Student and alumni athletes from UT institutions claimed an impressive 21 medals at the 2024 Paris Games – including nine gold. If the UT System were…
Liked by Paolo Cotzia
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Just finished my Master Class on #transitionfinance investment at the RiskMathics Financial Institute Risk Management and Trading 2024 conference in…
Just finished my Master Class on #transitionfinance investment at the RiskMathics Financial Institute Risk Management and Trading 2024 conference in…
Liked by Paolo Cotzia
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Robotic surgical approach. Coming soon..
Robotic surgical approach. Coming soon..
Liked by Paolo Cotzia
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#Pathologists from the #UK and #US are coming together to drive advancements in #globalpathologyeducation using #digitalpathology. Thrilled to…
#Pathologists from the #UK and #US are coming together to drive advancements in #globalpathologyeducation using #digitalpathology. Thrilled to…
Liked by Paolo Cotzia
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BREAKING: UT System Board of Regents announces plan to integrate The University of Texas at San Antonio and UT Health San Antonio into one premier…
BREAKING: UT System Board of Regents announces plan to integrate The University of Texas at San Antonio and UT Health San Antonio into one premier…
Liked by Paolo Cotzia
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For most patients with ER , HER2- #MetastaticBreastCancer (MBC), endocrine therapy is the therapeutic backbone throughout their treatment journey and…
For most patients with ER , HER2- #MetastaticBreastCancer (MBC), endocrine therapy is the therapeutic backbone throughout their treatment journey and…
Liked by Paolo Cotzia
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I am thrilled and humbled to step into the CTO & CEO role at Paige during this pivotal time in our journey. The past five years have been…
I am thrilled and humbled to step into the CTO & CEO role at Paige during this pivotal time in our journey. The past five years have been…
Liked by Paolo Cotzia
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The answer to the #Parasite Case 754 is now up: platelets overlying RBCs – an intraerythrocytic parasite mimic. More info on how to differentiate…
The answer to the #Parasite Case 754 is now up: platelets overlying RBCs – an intraerythrocytic parasite mimic. More info on how to differentiate…
Liked by Paolo Cotzia
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💊 Results of the NAPOLI-1 trial showed the benefits of nanoliposomal irinotecan with #fluorouracil and #leucovorin for pancreatic ductal…
💊 Results of the NAPOLI-1 trial showed the benefits of nanoliposomal irinotecan with #fluorouracil and #leucovorin for pancreatic ductal…
Liked by Paolo Cotzia
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A positive but negative #GVHD prophylaxis story with JAK2i. 🤔 Pacritinib reduced STAT3 in CD4 T cells (met primary endpoint!) and reduced Th1/Th17…
A positive but negative #GVHD prophylaxis story with JAK2i. 🤔 Pacritinib reduced STAT3 in CD4 T cells (met primary endpoint!) and reduced Th1/Th17…
Liked by Paolo Cotzia
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Just published: SPLICE - Streamlining Digital Pathology Image Processing A new unsupervised algorithm for patching WSIs; - finally a better…
Just published: SPLICE - Streamlining Digital Pathology Image Processing A new unsupervised algorithm for patching WSIs; - finally a better…
Liked by Paolo Cotzia
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