“Nikhil was my Marketing manager during my summer at Swell. As an intern, Nikhil gave me the autonomy I needed to grow, while also helping me work through more difficult tasks. We collaborated on a number of projects and I was impressed by his creativity, organization, and knowledge of the industry. I definitely recommend him as a hardworking and personable manager. ”
About
Focused on Product Positioning, Product Strategy, Go-to-Market Strategy, and Market…
Activity
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Yotpo is one of the most powerful examples of how a company-led social posting strategy can dramatically alter market perception and position…
Yotpo is one of the most powerful examples of how a company-led social posting strategy can dramatically alter market perception and position…
Liked by Nikhil Naidu
Experience
Education
Volunteer Experience
Publications
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Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection
The Journal of Clinical Investigation
Regulation of neutrophil activity is critical for immune evasion among extracellular pathogens, yet the mechanisms by which many bacteria disrupt phagocyte function remain unclear. Here, we have shown that the respiratory pathogen Streptococcus pneumoniae disables neutrophils by exploiting molecular mimicry to degrade platelet-activating factor (PAF), a host-derived inflammatory phospholipid. Using mass spectrometry and murine upper airway infection models, we demonstrated that…
Regulation of neutrophil activity is critical for immune evasion among extracellular pathogens, yet the mechanisms by which many bacteria disrupt phagocyte function remain unclear. Here, we have shown that the respiratory pathogen Streptococcus pneumoniae disables neutrophils by exploiting molecular mimicry to degrade platelet-activating factor (PAF), a host-derived inflammatory phospholipid. Using mass spectrometry and murine upper airway infection models, we demonstrated that phosphorylcholine (ChoP) moieties that are shared by PAF and the bacterial cell wall allow S. pneumoniae to leverage a ChoP-remodeling enzyme (Pce) to remove PAF from the airway. S. pneumoniae–mediated PAF deprivation impaired viability, activation, and bactericidal capacity among responding neutrophils. In the absence of Pce, neutrophils rapidly cleared S. pneumoniae from the airway and impeded invasive disease and transmission between mice. Abrogation of PAF signaling rendered Pce dispensable for S. pneumoniae persistence, reinforcing that this enzyme deprives neutrophils of essential PAF-mediated stimulation. Accordingly, exogenous activation of neutrophils overwhelmed Pce-mediated phagocyte disruption. Haemophilus influenzae also uses an enzyme, GlpQ, to hydrolyze ChoP and subvert PAF function, suggesting that mimicry-driven immune evasion is a common paradigm among respiratory pathogens. These results identify a mechanism by which shared molecular structures enable microbial enzymes to subvert host lipid signaling, suppress inflammation, and ensure bacterial persistence at the mucosa.
Other authors
Courses
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Econometrics
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Economic Statistics
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Financial Derivatives
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Healthcare Entrepreneurship
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Industrial Organization
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International Finance
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Monetary and Fiscal Policy
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Honors & Awards
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National AP Scholar
College Board
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National Merit Scholar
National Merit Scholarship Corporation
Test Scores
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SAT (Scholastic Aptitude Test)
Score: 2370 Cumulative
Reading: 800
Math: 770
Writing: 800
Languages
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English
Native or bilingual proficiency
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French
Limited working proficiency
Organizations
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Boy Scouts of America
Eagle Scout
- PresentEagle Scout with Troop 84 based in Somerville • Created a page for the county website recounting the history of Bridgewater, NJ from the perspective of longtime residents. Project required coordinating over 50 people.
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Static Noyze
Dancer
-Dancer at Static Noyze Dance Company, a professional hip-hop dance crew based in Boston, Massachusetts.
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Penn Masti
President and Captain
-Captain and President for Penn’s premier co-ed South-Asian dance troupe. • Led the group to the National Championships of Collegiate Bollywood Fusion Dance for two consecutive years. http://www.thedp.com/article/2016/04/masti-bollywood-america-2016 http://www.thedp.com/article/2016/02/penn-masti-advances-to-bollywood-america
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Martinsville Rescue Squad
EMT
-Volunteered an average of 15 hours/week as a first responder to 9-1-1 health emergencies. Certified Emergency Medical Technician.
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