José M. Mejía Oneto
San Francisco, California, United States
1K followers
500 connections
San Francisco, California, United States
1K followers
500 connections
About
Entrepreneurial physician-scientist with a passion for bridging basic science, technology…
Articles by José M.
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How do we expand the therapeutic index of antibody-drug conjugates?
How do we expand the therapeutic index of antibody-drug conjugates?
By José M. Mejía Oneto
Activity
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Sangeetha was one of the first few employees at Shasqi and has been an invaluable partner to me helping lead our research approach. I am honored to…
Sangeetha was one of the first few employees at Shasqi and has been an invaluable partner to me helping lead our research approach. I am honored to…
Shared by José M. Mejía Oneto
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To celebrate Sangeetha Srinivasan's 7-year anniversary, here are 7 reasons why we’re privileged to have Dr. Srinivasan on the Shasqi team. 1…
To celebrate Sangeetha Srinivasan's 7-year anniversary, here are 7 reasons why we’re privileged to have Dr. Srinivasan on the Shasqi team. 1…
Liked by José M. Mejía Oneto
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Sometimes it's just easier to see something than have it explained. I am delighted to see this new animation of our CAPAC technology come to life!
Sometimes it's just easier to see something than have it explained. I am delighted to see this new animation of our CAPAC technology come to life!
Shared by José M. Mejía Oneto
Experience
Education
Publications
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Implantable biomaterial based on click chemistry for targeting small molecules.
Acta biomaterialia
Specific and targeted delivery of medical therapies continues to be a challenge for the optimal treatment of multiple medical conditions. Technological advances permit physicians to target most sites of the body. However, after the intervention, physicians rely on systemic medications that need frequent dosing and may have noxious side effects. A novel system combining the temporal flexibility of systemic drug delivery and the spatial control of injectable biomaterials would improve the…
Specific and targeted delivery of medical therapies continues to be a challenge for the optimal treatment of multiple medical conditions. Technological advances permit physicians to target most sites of the body. However, after the intervention, physicians rely on systemic medications that need frequent dosing and may have noxious side effects. A novel system combining the temporal flexibility of systemic drug delivery and the spatial control of injectable biomaterials would improve the spatiotemporal control of medical therapies. Here we present an implantable biomaterial that harnesses in vivo click chemistry to enhance the delivery of suitable small molecules by an order of magnitude. The results demonstrate a simple and modular method to modify a biomaterial with small molecules in vitro and present an example of a polysaccharide modified hours after in vivo implantation. This approach provides the ability to precisely control the moment when biochemical and/or physical signals may appear in an implanted biomaterial. This is the first step towards the construction of a biomaterial that enhances the spatial location of systemic small molecules via in vivo chemical delivery.
Languages
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English
Native or bilingual proficiency
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Spanish
Native or bilingual proficiency
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German
Elementary proficiency
More activity by José M.
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Visualize a world where cancer drugs are activated only where they are needed. Want to (literally) see how that would work? Shasqi’s CAPAC…
Visualize a world where cancer drugs are activated only where they are needed. Want to (literally) see how that would work? Shasqi’s CAPAC…
Liked by José M. Mejía Oneto
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Congrats to Shasqi scientists Sangeetha Srinivasan and Stefanie Wagner on completing the #AACR24 5K this morning! 🏃♀️ 🏃♀️ #runners4research
Congrats to Shasqi scientists Sangeetha Srinivasan and Stefanie Wagner on completing the #AACR24 5K this morning! 🏃♀️ 🏃♀️ #runners4research
Liked by José M. Mejía Oneto
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We're looking forward to Carolyn Bertozzi's talk on next generation cancer therapies enabled by bioorthogonal chemistry at #AACR24. For the…
We're looking forward to Carolyn Bertozzi's talk on next generation cancer therapies enabled by bioorthogonal chemistry at #AACR24. For the…
Liked by José M. Mejía Oneto
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Huge congratulations to Patricia LoRusso on being elected American Association for Cancer Research President! 🎉 At Shasqi, we're incredibly…
Huge congratulations to Patricia LoRusso on being elected American Association for Cancer Research President! 🎉 At Shasqi, we're incredibly…
Liked by José M. Mejía Oneto
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#AACR24 is a great place to catch up in person, share our data, and enjoy free popcorn! George Coricor, José M. Mejía Oneto, Sangeetha Srinivasan…
#AACR24 is a great place to catch up in person, share our data, and enjoy free popcorn! George Coricor, José M. Mejía Oneto, Sangeetha Srinivasan…
Liked by José M. Mejía Oneto
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No need for FOMO. Come on over to Poster Section 26 at #AACR24 to meet the Shasqi team! #cancerresearch
No need for FOMO. Come on over to Poster Section 26 at #AACR24 to meet the Shasqi team! #cancerresearch
Liked by José M. Mejía Oneto
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So impressed by the level of activity around our poster sessions today! Thanks to everyone who came by to say hello. Nice job on presenting George…
So impressed by the level of activity around our poster sessions today! Thanks to everyone who came by to say hello. Nice job on presenting George…
Liked by José M. Mejía Oneto
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And that’s a wrap! Thank you American Association for Cancer Research for a fantastic annual meeting! There was so much to appreciate these past 6…
And that’s a wrap! Thank you American Association for Cancer Research for a fantastic annual meeting! There was so much to appreciate these past 6…
Liked by José M. Mejía Oneto
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This week has been very inspiring. I truly enjoyed being invited to speak at World ADC Event Series to share about the expansion of our CAPAC…
This week has been very inspiring. I truly enjoyed being invited to speak at World ADC Event Series to share about the expansion of our CAPAC…
Shared by José M. Mejía Oneto
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