John Mulligan, Ph.D.
Seattle, Washington, United States
2K followers
500 connections
About
My scientific expertise is in drug discovery, genetics, and molecular biology. I was an…
Activity
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What a week this has been for innovative companies in Seattle (first Smartsheet and now OctoAI). Today NVIDIA made public the news that they have…
What a week this has been for innovative companies in Seattle (first Smartsheet and now OctoAI). Today NVIDIA made public the news that they have…
Liked by John Mulligan, Ph.D.
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It was true when Geoffrey Chaucer wrote it in 1374, and it remains true today: all good things must come to an end. I’m sharing the bittersweet…
It was true when Geoffrey Chaucer wrote it in 1374, and it remains true today: all good things must come to an end. I’m sharing the bittersweet…
Liked by John Mulligan, Ph.D.
Experience
Education
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Stanford University
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Research on the regulation of Rhizobium meliloti nodulation genes under the direction of Dr. Sharon Long.
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Bacterial genetics research. Carried out what was probably the last experiment on glutamine synthetase auto-regulation for Boris Magasanik. Genetic analysis of the regulation of methionine biosynthetic genes in Graham Walker's lab led to a co-first author paper.
Publications
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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
Am J Hum Genet. 2001 Mar;68(3):577-89
Used human genetics to discover a target for drug development.
Patents
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Antibodies associated with alterations in bone density
Issued US 7,758,858
Compositions and methods for increasing bone density using antibodies directed to a novel class or family of TGF-.beta. binding proteins are provided. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of diseases associated with a loss of bone density, for example osteoporosis.
Other inventors -
Automated polymer-synthesis system
Filed US 20110256031
Embodiments of the present invention are directed to automated-polymer-synthesis systems that include discrete reagent-solution-addition, wait-time, and reagent-solution-draining sub-systems which together significantly increase throughput and decrease sub-system idle time. The automated-polymer-synthesis systems that represent embodiments of the present invention additionally include switches at points in which carriers can be received from multiple input paths or output to multiple different…
Embodiments of the present invention are directed to automated-polymer-synthesis systems that include discrete reagent-solution-addition, wait-time, and reagent-solution-draining sub-systems which together significantly increase throughput and decrease sub-system idle time. The automated-polymer-synthesis systems that represent embodiments of the present invention additionally include switches at points in which carriers can be received from multiple input paths or output to multiple different output paths. The automated-polymer-synthesis systems that represent embodiments of the present invention generally include an input spur and output spur in addition to a main loop, allowing carriers containing only completed polymers to be removed and new carriers input, so that carriers traverse the automated-polymer-synthesis systems independently from one another.
Other inventors -
Wicking-based reagent-solution draining in an automated system
Filed US 20110236270
Embodiments of the present invention include processing steps and subsystems, within automated-biopolymer-synthesis systems and within other automated systems for organic-chemistry-based processing, for removing reagent solutions and solvents from reaction chambers following various synthetic reaction steps and washing steps undertaken during biopolymer synthesis. Embodiments of the present invention employ any of various different types of liquid-absorbing materials to wick, or remove by…
Embodiments of the present invention include processing steps and subsystems, within automated-biopolymer-synthesis systems and within other automated systems for organic-chemistry-based processing, for removing reagent solutions and solvents from reaction chambers following various synthetic reaction steps and washing steps undertaken during biopolymer synthesis. Embodiments of the present invention employ any of various different types of liquid-absorbing materials to wick, or remove by capillary action, liquids from reaction chambers. Wicking-based methods and subcomponents of the present invention remove significantly greater fractions of solutions from reaction chambers than conventional methods and subsystems and, in addition, are mechanically simpler and produce fewer deleterious side effects than currently used methods and subsystems.
Other inventors
More activity by John
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Safari. A browser that’s actually private.
Safari. A browser that’s actually private.
Liked by John Mulligan, Ph.D.
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Today is OctoAI’s birthday! Its amazing how much we accomplished in a short few years. We pioneered ML compliers and now 100s of commercial and R&D…
Today is OctoAI’s birthday! Its amazing how much we accomplished in a short few years. We pioneered ML compliers and now 100s of commercial and R&D…
Liked by John Mulligan, Ph.D.
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We’re thrilled to announce the first close in a $15 million Series A financing round that supports development of our pipeline of therapies for…
We’re thrilled to announce the first close in a $15 million Series A financing round that supports development of our pipeline of therapies for…
Liked by John Mulligan, Ph.D.
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Curie now has more ways to #FreeTheFounders! We're excited to share the news regarding the Pro Rata Series A fund, which will enable us to further…
Curie now has more ways to #FreeTheFounders! We're excited to share the news regarding the Pro Rata Series A fund, which will enable us to further…
Liked by John Mulligan, Ph.D.
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