Gabriel Rezonzew, MD
Miami, Florida, United States
359 followers
361 connections
About
I am a highly motivated and creative scientist with expertise in Cell Culture, including…
Activity
Experience
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ODIN Bioscience
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Education
Volunteer Experience
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EMT/Fire fighter
Grosse Ile Fire Department, Michigan
- 2 years
Social Services
Great opportunity to help my community while learning emergency care
Publications
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MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha
Nature
MicroRNA (miR) are small conserved RNA that regulate gene expression post-transcription. Previous genome-wide analysis studies in preterm infants indicate that pathways of miR 219-5p are important in infants with Bronchopulmonary Dysplasia (BPD).
Taken together, our results demonstrate that increased miR-219-5p contributes to the pathogenesis of BPD by targeting and reducing PDGFR-α. The use of specific miRNA antagonists may be a therapeutic strategy for preventing the development of BPD.Other authorsSee publication -
The Close Eye Harbours a Unique Microbiome in Dry Eye Disease
Nature
Dry eye affects millions of individuals. In experimental models, dry eye disease is associated with T helper cell 17-mediated inflammation of the ocular surface that may cause persistent damage to the corneal epithelium. However, the initiating and perpetuating factors associated with chronic inflammation of the ocular surface remain unclear. The ocular microbiota alters ocular surface inflammation and may influence dry eye disease development and progression. Here, we collected serial samples…
Dry eye affects millions of individuals. In experimental models, dry eye disease is associated with T helper cell 17-mediated inflammation of the ocular surface that may cause persistent damage to the corneal epithelium. However, the initiating and perpetuating factors associated with chronic inflammation of the ocular surface remain unclear. The ocular microbiota alters ocular surface inflammation and may influence dry eye disease development and progression. Here, we collected serial samples of tears on awakening from sleep, closed eye tears, during a randomized clinical trial of a non-pharmaceutical dry eye therapy and used 16S rRNA metabarcoding to characterize the microbiome. We show the closed dry eye microbiome is distinct from the healthy closed eye microbiome, and that the microbiome remains distinct despite daily saline eye wash upon awakening. The ocular microbiome was described only recently, and this report implicates a distinct microbiome in ocular disease development. Our findings suggest an interplay between microbial commensals and inflammation on the ocular surface. This information may inform future studies of the pathophysiological mechanisms of dry eye disease.
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Activated PMN exosomes are pathogenic entities that cause destruction in the COPD lung
Cell
Here, we describe a novel pathogenic entity, the activated PMN (polymorphonuclear leukocyte, i.e., neutrophil)-derived exosome. These CD63 /CD66b nanovesicles acquire surface-bound neutrophil elastase (NE) during PMN degranulation, NE being oriented in a configuration resistant to α1-antitrypsin (α1AT). These exosomes bind and degrade extracellular matrix (ECM) via the integrin Mac-1 and NE, respectively, causing the hallmarks of chronic obstructive pulmonary disease (COPD). Due to both ECM…
Here, we describe a novel pathogenic entity, the activated PMN (polymorphonuclear leukocyte, i.e., neutrophil)-derived exosome. These CD63 /CD66b nanovesicles acquire surface-bound neutrophil elastase (NE) during PMN degranulation, NE being oriented in a configuration resistant to α1-antitrypsin (α1AT). These exosomes bind and degrade extracellular matrix (ECM) via the integrin Mac-1 and NE, respectively, causing the hallmarks of chronic obstructive pulmonary disease (COPD). Due to both ECM targeting and α1AT resistance, exosomal NE is far more potent than free NE. Importantly, such PMN-derived exosomes exist in clinical specimens from subjects with COPD but not healthy controls and are capable of transferring a COPD-like phenotype from humans to mice in an NE-driven manner. Similar findings were observed for another neutrophil-driven disease of ECM remodeling (bronchopulmonary dysplasia [BPD]). These findings reveal an unappreciated role for exosomes in the pathogenesis of disorders of ECM homeostasis such as COPD and BPD, providing a critical mechanism for proteolytic damage.
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ETS-1 In Salt Sensitive Hypertension: Interactions with the Renin Angiotensin System
American Society of Nephrology
Poster presentation ASN Kidney Week, Philadelphia, PA
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Diet Modulation is an Effective Complementary Agent in Preventing and Treating Breast Cancer Lung Metastasis
Clinical and Experimental Metastasis (Springer)
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Neointima Formation in AV Fistulas: Role of the Transcription Factor ETS-1
Amarican Society of Nephrology
Poster presentation ASN Kidney Week San Diego, CA
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Nicotinic Acetylcholine receptor expression and localization in the Human, Rat and Mouse Kidney
American Society of Nephrology
Poster presentation ASN Kidney Week San Diego, CA
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Role of the Transcription Factor Erythroblastosis Virus E26 Oncogen Homolog-1 (ETS-1) as Mediator of the Renal Proinflammatory and Profibrotic Effects of Angiotensin II
Hypertension
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The Signaling Pathways of Nicotine-induced ERK1/2 Phosphorylation in Rat Mesangial Cells
American Heart Association
Poster presentation High Blood Pressure Research Conference
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Nicotine exposure and the progression of chronic kidney disease: role of the 7-nicotinic acetylcholine receptor
AJP - Renal Physiology
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The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells
AJP - Renal Physiology
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Dietary Stearate Is an Effective Complementary Agent to Paclitaxel in Reducing the Incidence and Tumor Burden of Breast Cancer Lung Metastasis
University of Alabama at Birmingham
Poster presentation UAB
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Nicotine and the Progression of Chronic Kidney Disease: Role of COX-2 Derived Prostaglandins
Flight Attendant Medical Research Institute
Poster presentation Flight Attendant Medical Research Institute Ninth Scientific Symposium. Miami,
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In Vitro Matrices for Studying Tumor Cell Invasion, Book Series: Cancer Metastasis – Biology and Treatment
Springer Netherlands
Book chapter
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Invasion and Metastasis II, Phenotypic Characteristics of Neoplastic Progression in Breast Cancer Are Modulated by Alpha-L-Fucose
Department of the Army, Era of Hope
Book
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Glycosylation effects on human breast cancer cell adhesion & invasion are modulated through the simple sugar, fucose
American Association for Cancer Research
95th Annual Meeting Proceedings of the American Association for Cancer Research
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The Transcription Factor ETS-1 Is a Novel Mediator of Renal Injury is Salt Sensitive Hypertension
Hypertension
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Honors & Awards
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Nicotine and Chronic Kidney Disease: Role of the Alpha 7 Nicotinic ACh Receptor
American Society of Nephrology
Oral Presentation Kidney Week 2011, Philadelphia Convention Center, November 11
Languages
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Spanish
Native or bilingual proficiency
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English
Native or bilingual proficiency
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Hebrew
Limited working proficiency
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