Nicolas Encina

Nicolas Encina

Greater Boston
2K followers 500 connections

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About

Nic is an accomplished healthcare leader with extensive technical experience across…

Activity

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Experience

  • International Consortium on Newborn Sequencing (ICoNS) Graphic

    International Consortium on Newborn Sequencing (ICoNS)

    Boston, Massachusetts, United States

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    Ariadne Labs, Boston, Massachusetts, United States

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    Boston, Massachusetts, United States

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    Ariadne Labs, Boston, Massachusetts

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    Greater Boston Area

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    Greater Boston Area

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    Cambridge, MA

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    Waltham, MA

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    Cambridge, MA

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    Cambridge, Massachusetts, United States

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    Yale University

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    Marlborough, Massachusetts, United States

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    Greater St. Louis Area

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    St. Louis County, Missouri, United States

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Education

  • Yale School of Management Graphic

    Yale University - Yale School of Management

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    Founded the Yale Health Ecosystem -- a cross-disciplinary society of health professionals spanning the schools of Management, Law, Medicine, Nursing, and Public Health with the goal of openly tackling some of the most debated and controversial topics in healthcare.

  • Computational Molecular Biology

  • Activities and Societies: Sigma Xi

    Isolation and characterization of human osteoprogenitors from bone marrow stroma

  • Activities and Societies: Varsity Tennis

    Concentration in Neuroscience

Publications

  • Analysis Tool Automates Drug Discovery Data Acquisition and Management

    NASA Tech Briefs

    Pharmaceutical company uses calculation software to automate data capture, analysis, and visualization

    See publication

  • Iterative High-Throughput Polymorphism Studies on Acetaminophen and an Experimentally Derived Structure for Form III

    J. Am. Chem. Soc.

    Three crystal forms of acetaminophen were prepared and characterized using a newly developed high-throughput crystallization platform, CrystalMax. The platform consists of design software, robotic sample dispensing and handling, and high-throughput microanalytics and is capable of running thousands of crystallizations in parallel using several different methods to drive supersaturation and subsequent crystallization. Additionally, structural models of the elusive third form of acetaminophen…

    Three crystal forms of acetaminophen were prepared and characterized using a newly developed high-throughput crystallization platform, CrystalMax. The platform consists of design software, robotic sample dispensing and handling, and high-throughput microanalytics and is capable of running thousands of crystallizations in parallel using several different methods to drive supersaturation and subsequent crystallization. Additionally, structural models of the elusive third form of acetaminophen will be discussed on the basis of powder X-ray diffraction data. One structure suggested has a bilayer motif, held together by O−H···O(H) hydrogen bonds, and helps explain the difficulty associated with preparing this form from solution.

    See publication

  • Immunomagnetic Isolation of Osteoprogenitors from Human Bone Marrow Stroma

    Laboratory Investigation

    We report here the efficient and specific isolation of human bone marrow osteoprogenitors using magnetic beads coated with a mouse mAb (STRO-1) that recognizes a stromal cell surface protein. According to their pattern of differentiation, osteoprogenitors accounted for 100% of the STRO-1-positive cell population. Upon long term culture, osteoprogenitors differentiated down the osteoblastic lineage as evidenced by their in vitro morphology, their increased expression of alkaline phosphatase…

    We report here the efficient and specific isolation of human bone marrow osteoprogenitors using magnetic beads coated with a mouse mAb (STRO-1) that recognizes a stromal cell surface protein. According to their pattern of differentiation, osteoprogenitors accounted for 100% of the STRO-1-positive cell population. Upon long term culture, osteoprogenitors differentiated down the osteoblastic lineage as evidenced by their in vitro morphology, their increased expression of alkaline phosphatase, their production of osteocalcin, and the deposition of a mineralized matrix. Upon differentiation, the cells first expressed alkaline phosphatase on their surface before they began proliferating as phenotypically recognizable osteoblasts. This observation conflicts with previous studies that have characterized human osteoprogenitors as highly proliferative cells that form colonies before differentiating into osteoblasts. The ability to isolate and cultivate pure populations of primary human osteoprogenitors will substantially advance investigations on osteogenesis and bone remodeling.

    Other authors
    • Billotte WG
    • Hofmann MC.
    See publication

Patents

  • Scientific Research And Collaboration System And Method

    Issued US 61/333,940

    This invention relates to methods and apparatus that are designed to assist researchers with their research and their collaboration with other researchers.

    Other inventors

  • Document Processing

    Issued US 7,707,206

    In one general aspect the method features fingerprinting digitally stored documents and queries based on one or more topic models. Similarities between document and query fingerprints can be detected to search for documents. Topic summaries can also be derived from the documents and queries based on the topic models.

    Other inventors
    See patent

  • Document Similarity by Concept Identification

    Filed US 60/719,101

  • Search and Organize by Topic Recognition

    Filed US 60/719,100

Languages

  • English

    Native or bilingual proficiency

  • Spanish

    Native or bilingual proficiency

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