ThrombUS Horizon EU Project

Deep vein thrombosis (DVT) poses a significant health risk, with potentially life-threatening consequences when left undetected. ThrombUS is set to redefine DVT care with an ambitious mission to develop an innovative wearable diagnostic device for point-of-care, operator-free, continuous monitoring. DVT involves the formation of blood clots in deep veins, primarily in the lower limbs, leading to blood flow obstruction. Shockingly, up to two-thirds of DVT cases exhibit no clinical symptoms, making early diagnosis challenging. ThrombUS steps in to bridge this gap, bringing together a diverse team of experts spanning industry, technology, regulation, social science, and clinical trials. Our interdisciplinary approach centers around creating a novel wearable diagnostic device utilizing autonomous, AI-driven DVT detection. This groundbreaking device incorporates wearable ultrasound hardware, impedance plethysmography, and light reflection rheography for immediate clot detection. Activity and physiological measurements will continuously assess DVT risk, supporting prevention through serious gaming. An intelligent decision support unit will provide real-time monitoring and alerts, with extended reality guiding users for optimal device utilization. With a duration of 42 months, ThrombUS kicks off on January 1, 2024, and concludes on June 30, 2027. The project has 18 partners from Greece, Lithuania, France, Germany, the USA, Italy, Finland, and Spain. The Horizon Europe Innovation Action funds the venture with 9.5 M€. ThrombUS will leverage big datasets collected through three large-scale clinical studies for AI training. Validation will be carried out in clinical settings through one early feasibility study and one multi-center clinical trial. Learn more at thrombus.eu #thrombosis #DVT #earlydetection #HorizonEurope

On June 26, ThrombUS participated in an EU online clustering event. The event was organized by the European Health and Digital Executive Agency (HaDEA).   In the beginning, HaDEA officials presented some general information for new projects, including guidelines for successful dissemination.   Then, the Coordinators of the projects funded under the same call (HORIZON-HLTH-2023-TOOL-05-05) were asked to present their projects. Full list of projects: AIRCARE, AI-Augmented Robotics for Cancer Point of Care coordinated by Leonardo Mattos HoloSurge HaDEA Project Next-Generation Real-Time Holographic Navigation in the Operating Room coordinated by Jonas Tyssø RealCare, Real-Time Biomarker Detection Systems For Rapid Medical Decision-Making In Cancer And Cardiac Diseases coordinated by Loes Segerink STRATUM Project 3D Decision Support Tool for Brain Tumor Surgery coordinated by Gustavo Marrero Callico POC4TRIAGE Point-of-Care Devices for Urgent Care Triage coordinated by Matti Kaisti ThrombUS Horizon EU Project Wearable Continuous Point-of-Care Monitoring, Risk Estimation and Prevention for Deep Vein Thrombosis coordinated by Eleni Kaldoudi #HorizonEurope #HaDEA #healthcare #DVT

See Director Eleni Kaldoudi's presentation on Gender Balance Awareness as part of the ThrombUS project's goal to create awareness on gender balance and on sustainable and equitable innovation. https://lnkd.in/gBpQvdZh She Figures 2021: Gender in Research and Innovation Statistics and Indicators https://lnkd.in/gEbVRy5V View all the ThrombUS presentations: https://lnkd.in/gHZWGqfS #GenderEquality #Innovation #genderbalance

Pregnancy and the postpartum period significantly increase the risk of developing deep vein thrombosis (DVT) due to physiological changes in blood coagulation and venous stasis. Here are some statistics and data on how these factors influence clot tendency and DVT risk in Europe: 🤰 Pregnancy: Pregnant women have a 5 to 10 times higher risk of developing DVT compared to non-pregnant women of the same age. The risk is highest during the third trimester. 👩🍼 Postpartum Period: The risk of DVT is even higher in the postpartum period, particularly in the first 6 weeks after childbirth. During this time, women have a 20 to 80 times higher risk of developing DVT compared to non-pregnant women. 📈 Incidence Rates: The incidence of DVT during pregnancy and the postpartum period in Europe is estimated to be about 1 in 1,000 pregnancies. This can vary depending on the country and specific population demographics. ⚠️ Comparative Risk: While the baseline risk of DVT in women of childbearing age (15-44 years) is approximately 1 to 5 per 10,000 women per year, this risk increases substantially during pregnancy and after delivery. 🩸 Venous Thromboembolism (VTE), which includes both DVT and pulmonary embolism (PE), is a significant contributor to maternal mortality. It accounts for about 1.2 deaths per 100,000 live births in Europe. #DVT #Fact #Thrombosis #EarlyDetection #HorizonEurope

Project manager Stylianos Didaskalou presented a talk titled "Towards Wearable Continuous Point-of-Care Monitoring for Deep Vein Thrombosis of the Lower Limb" at the European Medical and Biological Engineering Conference (EMBEC2024) last month. The event hosted 250 participants and successfully bridged fundamental and clinically-oriented research, emphasizing the pivotal role of translational research in biomedical engineering. Read more about the conference and view the full presentation on the ThrombUS website: https://lnkd.in/dqpruiE9 #DVT #HorizonEurope #EarlyDetection #EMBEC2024

#ThrombUS wearable prototypes These wearables were presented at our last in-person project meeting in Kaunas, Lithuania. This groundbreaking device will incorporate wearable ultrasound hardware, impedance plethysmography, and light reflection rheography for immediate clot detection. Activity and physiological measurements will continuously assess DVT risk, supporting prevention through serious gaming. An intelligent decision support unit will provide real-time monitoring and alerts, with extended reality guiding users for optimal device utilization. ThrombUS is designed for postoperative patients, those undergoing lengthy surgical procedures, cancer patients, bedridden individuals at home or in care units, and women during pregnancy and postpartum. #DVT #thrombosis #prototype #HorizonEurope

On June 26 Project Director Eleni Kaldoudi presented the ThrombUS project at the Horizon Europe Health Cluster Networking Meeting hosted by the European Health and Digital Executive Agency (HaDEA) chaired by Dusan Sandor. View the presentation and project overview on SlideShare: https://lnkd.in/d9Bqv92y #HorizonEurope #DVT #EarlyDetection #Ultrasound

Want to dive deeper into the ThrombUS Horizon EU Project we're involved in? Check out the video! And to stay always updated, be sure to subscribe to ThrombUS Newsletter: https://lnkd.in/dQA4UqXy #HorizonEurope #earlydetection #DVT

"Wearable ultrasound systems hold great promise for transforming health care, supporting a shift towards preventive care and proactive health management. In clinical settings, they offer the potential for constant monitoring of high-risk patients, tracking fetal health in high-risk pregnancies or overseeing recovery after surgery. Beyond hospitals, these devices could bring diagnostic and monitoring tools to remote areas, making medical imaging more accessible and affordable in low- and middle-income countries. As the technology is refined, we foresee its integration into the daily lives of individuals to manage chronic conditions such as hypertension, or to enable early detection of heart failure, abdominal aortic aneurysms and deep vein thrombosis." Read the full article in Nature: https://lnkd.in/deaUkbSN Authors: Chonghe Wang and Xuanhe Zhao #EarlyDetection #wearableultrasound #DeepVeinThrombosis

The ThrombUS project recently acquired the Pôle S2E2 certification! S2E2 is a French Competitiveness Cluster with 250 industrial and academic members, located in France and working in the field of electronic systems & energy. S2E2 certification is bestowed after an evaluation process by a scientific council, to the best innovative projects submitted by members to calls of projects at regional, national & European levels. This certification is recognized by public funding authorities as a quality indicator of a project and gives visibility to the project, especially in France. The project will be specially supported by the S2E2 staff, located in France and in Brussels, Belgium, in the communication & dissemination actions of the project results, through events and media. Read more: https://lnkd.in/dbGnYK93 #s2e2 #HorizonEU #thrombosis #earlydetection