SynVivo, Inc

Vascular geometry and perfusion status of vasculature surrounding tumors can impact drug delivery and efficacy. Create in vivo-like tumor heterogeneity and vascularization to test drug delivery, efficacy, metastasis and anti-cancer therapeutics with the SynTumor -on-Chip platform. Key Features and Benefits: 1. Microvascular Networks: SynTumor -on-Chip incorporates realistic, perfusable vascular networks, which are crucial for mimicking the blood flow and nutrient supply in tumors. This feature allows for the study of drug delivery and distribution within a tumor, mirroring the in vivo conditions more closely. 2. 3D Tumor Microenvironment: The platform supports the growth of tumor cells in a three-dimensional structure, which better replicates actual tumor architecture and cell-cell interactions found in the human body. This 3D environment is critical for understanding how tumors grow, invade surrounding tissues, and respond to therapies. 3. Real-Time Monitoring: The technology allows for continuous observation and analysis of tumor behavior and drug effects in real time. This capability provides dynamic insights into the mechanisms of drug action, resistance, and tumor progression. 4. Customizability: SynTumor -on-Chip can be tailored to model specific types of cancers, making it a versatile tool for research on different tumor types and for personalized medicine approaches. Researchers can recreate specific tumor microenvironments to study targeted therapies and personalized treatment strategies. 5. Reduced Animal Testing: By offering a more accurate representation of human tumors, SynTumor-on-Chip has the potential to reduce reliance on animal models in preclinical testing. This aligns both with the 3Rs mission and enhances the predictive power of preclinical studies. Learn more and explore publications at https://lnkd.in/gecgeBsp. #SynTumor #Synvivobio #SynVivo

The blood-brain-barrier is a highly selective barrier protecting the brain from foreign matter. Its remarkable effectiveness also poses a significant challenge in delivering therapeutics to treat central nervous system diseases. SynVivo has developed a physiologically relevant human blood-brain-barrier-on-a-chip to assess permeability of drugs, neuroinflammation and therapeutic screening. Find more details and publications at https://lnkd.in/g6xpxDJN #SynVivo #synvivobio #SynBBB #bloodbrainbarrier

We’re already on day 3 at the MPS World Summit! Day 1 kicked off with a packed hands-on sessions in our educational workshop led by Deborah Ramsey, Ph.D., followed by two fantastic days of discussing all things MPS at booth #87. If you haven't had a chance yet, there's still time to meet with our team and learn more about our offerings or check out one of our poster presentations. Poster 183: Small Airway Lung-on-Chip Model for evaluating neutrophil - mediated damaged in inflamed lung tissues Poster 328: Blood-Brain-Barrier-on-Chip models for more predictive in vitro modeling of Receptor Mediated Transcytosis

Join Gwen Fewell, Deborah Ramsey, Ph.D. and Grace McGrew this week at the MPS World Summit. Visit us at SynVivo's booth #87, join our session at the Educational Workshop, or meet us at one of our poster presentations. We look forward to seeing you there! #SynVivo #synvivobio #MPSWorldSummit2024 #OrganChip

Join Gwen Fewell, Deborah Ramsey, Ph.D. and Grace McGrew this week at the MPS World Summit. Visit us at SynVivo's booth #87, join our session at the Educational Workshop, or meet us at one of our poster presentations. We look forward to seeing you there! #SynVivo #synvivobio #MPSWorldSummit2024 #OrganChip

We're excited to be exhibiting at the MPS World Summit in Seattle, Washington. Visit us at our booth, attend our session at the Educational Workshop, or visit our poster presentations on Blood-Brain-Barrier and Lung ALI-on-Chip models. We can't wait to connect with you there! #SynVivo #synvivobio #OrganChip #MPSWorldSummit2024

Come visit us at AACR Booth #117. We are excited to discuss our vascularized tumor-on-chip models for your oncology applications. #AACR2024 Deborah Ramsey, Ph.D. Gwen Fewell #SynVivo #tumoronchip

We are excited to be headed to sunny San Diego for AACR 2024! Come visit us at Booth #117 or stop by our poster presentation to learn about our Vascularized Tumor-on-Chip models. We look forward to seeing you! #AACR2024 #SynVivo #tumoronchip #OrganChip #synvivobio

Day 1 of ToxExpo. Come by Booth #1700. Our team is here and excited to meet with you. Join our speaking session today in Room 155C: 1:30pm #2024sot #ToxExpo #SynVivo Gwen Fewell Deborah Ramsey, Ph.D. Grace McGrew

We are heading to Salt Lake City March 10-14 for the annual Society for Toxicology meeting. Find us at Booth #1700, our Speaking Session or one of our posters! 📆 Monday, March 11, 2024 Speaker Session: Vascularized Organ-on-Chip Models: Applications in Drug Safety and Efficacy Testing Presenters: Gwen Fewell, PhD President and CEO SynVivo Inc., Deborah Ramsey, Ph.D., Director of Scientific Development, SynVivo Inc. 🕰 Time: 1:30-2:30pm 📍 Location: Room 155C 📆 Tuesday, March 12, 2024 Small Airway Lung-on-Chip Model for Evaluating Neutrophil-Mediated Damage in inflamed Lung Tissue Presenter: Deborah Ramsey, Ph.D., Director of Scientific Development, SynVivo Inc. 🕰 Time: 11:45-1:45pm 📍 Poster Board #P682 Blood-Brain-Barrier-on-Chip Models for More Predictive In Vitro Modelling of Antibody-Triggered Receptor-Mediated Transcytosis Presenter: Gwen Fewell, PhD President and CEO at SynVivo Inc. 🕰 Time: 2:25-4:15pm 📍 Poster Board #772 #2024SOT #ToxExpo #SynVivo #synvivobio #OrganChip