Stämm

Mostly everyone in the biomanufacturing industry deals with inefficient oxygen distribution inside their bioreactors. Optimal oxygen transfer within bioreactors is critical for improved cell growth and product yield. Sparging remains one of the most commonly used techniques for oxygenation within the bioreactor. However, there are several frustrating issues with this method: 1. Bubble size & distribution: Achieving precise bubble size is crucial. Only the right bubble size is efficient. You lose efficiency if they are too large, but excessive foaming and shear stress can occur if they are too small. 2. Shear Stress: The potent sparging needed for oxygenation often results in high shear stress, damaging cells and causing lower viability and productivity. 3. Foaming: Excessive sparging causes it, for which you must add an antifogging agent, which harms the cell culture. These challenges can significantly impact your work. But what if there was a better way?

Congratulations to our Stämmer of the Week, Facundo Enriquez! Working in biotechnology involves a wide variety of high-tech instruments and equipment that are often difficult to access. Between waiting, payments, shipments, and comparisons, valuable time can be spent in an industry that can never stop innovating. In a situation like this, Facundo cut the wait short and carried out the design, prototyping, and validation of an essential piece of equipment for our bioreactor. Instead of waiting for the commercial solution, he provided us with an in-house solution, which even surpassed the features of its market equivalent. While honoring his role as a rapid prototyping specialist, Facundo documented each step following design good manufacturing practices (GMP) to justify each decision. After gathering the needs and requirements of the development team, he delivered a satisfactory outcome for a key part of the bioprocessor. Knowing that our installed capacity increases week by week thanks to the creativity and practicality of our Stämmers is a source of pride. Facundo's willingness to take on this challenge made him complete the entire design cycle from start to finish. His skills as an electromechanical technician have already been noticed in Stämm and more than one division counts on his capacity for developing in-house prototypes. Thank you, Facundo, for your diligence in solving development challenges!

We shared insights about our groundbreaking continuous production technology at the Bio International Convention 2024, engaging with industry leaders and innovators. Discover how Stämm is pioneering a paradigm shift in biomanufacturing, driving efficiency, scalability, and innovation. Learn more about our experience and the future of biomanufacturing.

Congratulations to our Stämmer of the Week, Tobias Nicolas Santagada! Back-end is not the simplest thing to explain. It is invisible to the user: you see a button, log in automatically, and expect your data to sync. All that black box works silently behind, creating the feeling that any sufficiently complicated technology is indistinguishable from magic. Tobias, the back-end department leader, and his team are in charge of this behind-the-scenes operation of Stämm’s scientific web apps. They manage the databases and services users rely on seamlessly in their daily work. For an organization of our size to function, there are many mechanisms underlying every one, from assay saves to automated log-ins. The consistency and stability they bring to different divisions make users rely on the platforms for internal use. Thus, those working in laboratories, offices, or workshops only have to think about their tasks, avoiding digital pain points. Stämm benefits from interdisciplinary work. The team aims to centralize information, leading to predictive and expeditive analyses spanning disciplines. They have the triad to solve user problems: back-end, front-end, and UX/UI design. Thus, the user experience is made as friendly as possible. In any case, Tobias continues his quest to abstract solutions and create microservices to put together several APIs and reuse previous work. It allows them to update less often, fix bugs in a single place, and only worry about communication between components. Thank you, Tobias, for your work backstage for the well-being of Stämm's users!

We are excited to welcome the new Stämmers who were incorporated last month! Maria Florencia REYES joined our Numbers Teäm as a National Purchasing Specialist. She has a background in administration, management, and project planning. Victoria Reppucci joined our Models Teäm as a Machine Learning Specialist. She has a data science, bioengineering, and machine learning background with a Master’s degree from ITBA Universidad in biomedical engineering. Tomás Eidelman joined our Molecules Teäm as a Bio-Analytics Specialist. He has a background in research and lab work in neuroscience and molecular biology with a Biology degree from Universidad de Buenos Aires. Belkis Romero joined our Quality Operations Teäm as a Quality Assurance Specialist. She has a degree in chemical engineering from the Universidad de Oriente (VE) with knowledge of ISO 9001 and QA Systems. Carlos Alberto Ilnicki joined our Quality Operations Teäm as an Infrastructure & Maintenance Specialist. He has experience managing a crew and knowledge as an electrician and in plumbing. Carlos Monico joined our E-Division Teäm as a Processes Automation Specialist. He has an electronics technician and analyst background with experience in instrumentation and quality management. We are glad you have joined our teams! #NewHires #ExponentialGrowth #Startup #biotech

Biomanufacturing requires validated and stable devices. Standardizing procedures requires a lot of iteration and fine-tuning. Today, designing new processes and scaling them up is a challenge, especially for new instrumentation and manufacturing methods. That's where our Biomanufacturing Qualification (BQ) team comes in. BQ is the group of biology specialists that test, verify, and validate the technologies developed by Stämm. To achieve this, they receive cells and media and produce results studied with bioanalytics. At Stämm, we test and optimize our products, such as our Bioprocessor, to continually improve them. BQ analyzes, adjusts, and discovers the most efficient ways to leverage them. In search of safety and traceability, they carry out tests and document them to ensure repeatability. The group is heterogeneous in their backgrounds: PhDs from academia, specialists from large industries, and others from the biotech startup world. This complementarity favors collaborative and interdisciplinary work, generating a cooperative environment. Their vision is dual. With the future in mind, BQ thinks about scaling for tomorrow. As for the present, their attention to detail makes it possible to shape that horizon. They require long hours in the lab, coordination, and trust: a consolidated team. The high volume of work can only be divided because the team members rely on each other. BQ transmits this internal way of doing things to the outside world, helping Stämm network with other companies. Missions such as BioArk's in Switzerland include their representatives, whose future role oscillates between operators and facilitators of the disruptive technologies they develop. Thank you, BQ, for helping bring together Stämm's technologies and the company's innovations! Stay tuned for our next Teäm Spotlight!

Congratulations to our Stämmer of the Week, Francisco Gustavo Correa Tedesco! Microfluidics has an issue: not many people understand the technology. Be it because of previous misconceptions or because they never heard of it before. Generally, it is associated with minor applications or small-scale trials. But at Stämm, it’s much more than that. Professionals like Francisco Correa, a Physicist, and Biotechnology PhD, seek to apply microfluidics at an industrial scale. To that end, they are developing a complex in-house installed capacity to cover biomanufacturing's future needs. The object of study goes beyond selecting, modifying, or multiplying cells. The aim is to do all this while being competitive at the industrial level by cost, simplicity, and speed. This requires deep research & development. Fran explores the possibilities of microfabrication, from millifluidics to microfluidics, making functional devices up to 200 times smaller than previous prototypes and approaching the 10-micrometer scale. Although operating at the micron scale, he knows he is not alone in his endeavor. His team's collective interest in solving these challenges makes it an interdisciplinary venture. The environment Stämm provides gives him independence, rapid iterations, speed of development, and a wide range of designs delivered as a result. Thanks to that, Fran provides innovative solutions to current industry concerns, proving to be at the forefront of his field. Thank you, Fran, for connecting extensive know-how and leaping forward in development!

In nature, cells grow in microvessel networks. In Stämm's bioreactors too. This is only possible by using microfluidics to mimic their natural environment. It's a common misconception that microfluidics can only be used in small volumes. Our in-house 3D printing technology allows us to apply this technology to large-scale bioreactors.

🚀 (Back to) the Future of Biomanufacturing! From Monthey to Argentina, our latest Deep Dive event organised with BioArk took us on an insightful journey. 💡 It was a full house at BioArk II where experts gathered to exchange about what the future of biomanufacturing holds. Thank you to everyone who joined us and our guest speakers: Sébastien Walpen , Daniel Luescher, Juan Martin Cabaleiro & Tibor Anderlei. 🌟 More Deep Dive events coming soon. 👀 https://lnkd.in/dE-Z6wyR Stämm, QBDC GmbH, CEIDOS, Massimo Nobile Frédérique Brunner (Décaillet) Magali Bischof #lifesciences #innovation #events

¡Stämm recibió a los estudiantes del IUDPT ! Luego de la charla de Federico D'Alvia Vegh (Co-Founder y COO) sobre Stämm, estudiantes del Instituto Universitario para el Desarrollo Productivo y Tecnológico vinieron a visitar nuestras instalaciones. Al ser una universidad de bioingeniería y tecnología, Ignacio Campanelli, Head of Products, hizo un recorrido por laboratorios, talleres, salas de trabajo y oficinas de nuestra sede en Argentina. Agradecemos al IUDPT por el interés y esperamos que la visita haya sido inspiradora al descubrir cómo hacemos que la biomanufactura sea fácil, escalable, repetible y sostenible.