Stämm

Mostly everyone in the biomanufacturing industry deals with inefficient oxygen distribution inside their bioreactors. Optimal oxygen transfer within bioreactors is critical for improved cell growth and product yield. Sparging remains one of the most commonly used techniques for oxygenation within the bioreactor. However, there are several frustrating issues with this method: 1. Bubble size & distribution: Achieving precise bubble size is crucial. Only the right bubble size is efficient. You lose efficiency if they are too large, but excessive foaming and shear stress can occur if they are too small. 2. Shear Stress: The potent sparging needed for oxygenation often results in high shear stress, damaging cells and causing lower viability and productivity. 3. Foaming: Excessive sparging causes it, for which you must add an antifogging agent, which harms the cell culture. These challenges can significantly impact your work. But what if there was a better way?

Martin Carlos Gomez & Julian Axel Bergier lead a team focused on cell line establishment, a critical starting point in the biomanufacturing cycle. Working alongside María Florencia Arbe, Ph.D., Sofia Lage Vickers, Luciana Salaverry, and Mariángeles Díaz, the team works on developing innovative technologies that increase the precision and automation of the process ensuring the robustness and quality of the cells. In their latest achievement, the team developed a proprietary cell line capable of producing a biosimilar monoclonal antibody. They successfully designed, isolated, and identified a stable cell line, proving our biomanufacturing capabilities. Their work aligns with our mission to support clients from DNA sequence design to developing a stable cell line, ready for biomanufacturing. Our platforms focus is helping clients optimize their manufacturing process and achieve the most productive yield. We offer cell line development as a standalone service or as part of an integrated, end-to-end solution, scaling from lab to commercial production, and shortening development times. Our approach aims not only to accelerate the path to market but also to support the growing demand for personalized medicine, making it easier for our clients to meet the unique needs of their patients. Thank you to the Cell Line Establishment team for showcasing Stämm's commitment to innovation. Your dedication drives our capacity for evolution and growth! #CellLineEstablishment #Biomanufacturing #Biotech #Innovation #Antibodies

The future of biomanufacturing: scalable, biocompatible 3D printing resins The biomanufacturing industry is evolving rapidly with the development of scalable 3D printing resins. These advanced materials promise to reshape bioreactor design, enabling innovative shapes and precise environmental control. Resins are set to transform biomanufacturing processes, from formulation and production to safety and efficacy. At Stämm, we produce biocompatible resins in-house, ensuring quality and customization for industrial needs. 🔗 Read the full article to explore this disruptive technology: https://bit.ly/4fMs2Km #Biotech #Innovation #3DPrinting #Biomanufacturing #DeepTech #Stämm

Congratulations to our Stämmer of the Week, Maximiliano Rinaldi! Electronics is omnipresent in our lives. It has reached the point where most users don't even know how the devices around them work. Biomanufacturing is not exempt from this: devices need circuits, connections, modules, and firmware to fulfill their functions robustly and reliably. Maxi, from our electronics team, has been leading a flexible crew with well-oiled dynamics for a long time. His impact is crucial: they make in-house devices for our products. From high-precision fluid control to environmental condition measurement. Commercial solutions lack specificity. That's why Stämm's tech stack is far-reaching. Following good manufacturing practices, we standardize parts and controllers, eliminating redundancy and saving time. This gives us flexibility, reliability, and consistency in results. With the bioprocessor at the forefront, Stämm's product range is in safe hands thanks to Maxi and the electronics team, who manage to consolidate, modularize, and strengthen our installed capacity, ever-pushing innovation. Thank you, Maxi, for once again contributing with your predisposition!

Congratulations to Angelica Pineda for obtaining her PhD in Pharmacy and Biochemistry with a specialization in Biological Sciences from the University of Buenos Aires!

Pablo Federico Orellana joined our E-Division Teäm as an Electronics Specialist. He is an electronic technician and has a 3D printing and a research & development background. Nicolás Darmón joined our Numbers Teäm as a Stock Center Specialist. He has a background in logistics, including transportation, administration, and team leading. Natalia Casalanguida joined our People Teäm as a Technical Curator. She has a background in HR, a degree in business administration from the Universidad de Buenos Aires, and postgraduate studies at the Universidad de San Andrés. Pauline Ygonette, PMP joined our Adaptative Systems Teäm as an Agile Specialist. She has experience in the pharmaceutical industry, project management, and an engineering degree from AgroParisTech. Julian Salvador Francés joined our Light Based Solutions Teäm as a Brick Printing Specialist. He studies industrial design at the Universidad de Buenos Aires with a 3D & graphic design background. Lucas Rotuno joined our IT Teäm as an Infrastructure Specialist. He has a background in IT and technical support and a degree in computer science from the Universidad Nacional de Quilmes. Pilar Goñi joined our Biomanufacturing Qualification Teäm as a Qualification Iteration Specialist. She has a degree in biochemistry from the Universidad de Buenos Aires and a research background in chemistry and molecular biology. Candela Alonso joined our Light Based Solutions Teäm as a Brick Printing Specialist. She has a 3D design & UX/UI background and is studying industrial design at the Universidad de Buenos Aires. Emiliano Jan joined our Software Engineering Teäm as a Computer Science Specialist. He is an electronic engineer with a PhD from the Universidad de Buenos Aires, with a background in numerical simulations and optics. Matias Quarchioni joined our IT Teäm as a Help Desk Specialist. He is studying for a degree in information technology management at UADE and brings a background in engineering and electronics from UTN Buenos Aires.

Congratulations to our Stämmers of the Week, Victoria Paes de Lima, Tobias Fagioli, Pedro Rey, Augusto Huber, Manuel Collaud, Elian Russo, Damian Cabañas Escalante, Agustina Maria Beraldi, Camila Dib Blanco, Julian Guzmán! Innovation is relentless. It drives industry reinvention, transforming past technologies into better solutions for today. This continuous progress challenges even the most established players. At Stämm, we develop microfluidic bioreactors to reshape global biomanufacturing. Our technology enables seamless continuous production from laboratory to industry scale. This week, our Stämmers worked tirelessly to deliver a new bioreactor model that maximizes internal cell growth volume. This model sets a new record for printing volume. This achievement was possible thanks to the collaboration between our Simulations, Concept design, Prototyping, 3D Printing, and Chem teams. From computational modeling and fluid dynamics to design and rendering, 3D printing, auxiliary parts prototyping, and complete post-processing, each team played a crucial role. We can't share all the details yet because of confidentiality but stay tuned to learn how we're making biomanufacturing easy, scalable, repeatable, and sustainable. Follow Stämm for the latest updates! Thank you to all Stämmers who continuously strive to exceed expectations week after week!

Congratulations to our Stämmer of the Week, Facundo Enriquez! Working in biotechnology involves a wide variety of high-tech instruments and equipment that are often difficult to access. Between waiting, payments, shipments, and comparisons, valuable time can be spent in an industry that can never stop innovating. In a situation like this, Facundo cut the wait short and carried out the design, prototyping, and validation of an essential piece of equipment for our bioreactor. Instead of waiting for the commercial solution, he provided us with an in-house solution, which even surpassed the features of its market equivalent. While honoring his role as a rapid prototyping specialist, Facundo documented each step following design good manufacturing practices (GMP) to justify each decision. After gathering the needs and requirements of the development team, he delivered a satisfactory outcome for a key part of the bioprocessor. Knowing that our installed capacity increases week by week thanks to the creativity and practicality of our Stämmers is a source of pride. Facundo's willingness to take on this challenge made him complete the entire design cycle from start to finish. His skills as an electromechanical technician have already been noticed in Stämm and more than one division counts on his capacity for developing in-house prototypes. Thank you, Facundo, for your diligence in solving development challenges!

We shared insights about our groundbreaking continuous production technology at the Bio International Convention 2024, engaging with industry leaders and innovators. Discover how Stämm is pioneering a paradigm shift in biomanufacturing, driving efficiency, scalability, and innovation. Learn more about our experience and the future of biomanufacturing.

Congratulations to our Stämmer of the Week, Tobias Nicolas Santagada! Back-end is not the simplest thing to explain. It is invisible to the user: you see a button, log in automatically, and expect your data to sync. All that black box works silently behind, creating the feeling that any sufficiently complicated technology is indistinguishable from magic. Tobias, the back-end department leader, and his team are in charge of this behind-the-scenes operation of Stämm’s scientific web apps. They manage the databases and services users rely on seamlessly in their daily work. For an organization of our size to function, there are many mechanisms underlying every one, from assay saves to automated log-ins. The consistency and stability they bring to different divisions make users rely on the platforms for internal use. Thus, those working in laboratories, offices, or workshops only have to think about their tasks, avoiding digital pain points. Stämm benefits from interdisciplinary work. The team aims to centralize information, leading to predictive and expeditive analyses spanning disciplines. They have the triad to solve user problems: back-end, front-end, and UX/UI design. Thus, the user experience is made as friendly as possible. In any case, Tobias continues his quest to abstract solutions and create microservices to put together several APIs and reuse previous work. It allows them to update less often, fix bugs in a single place, and only worry about communication between components. Thank you, Tobias, for your work backstage for the well-being of Stämm's users!