Institute for In Vitro Sciences, Inc.

Earlier this month, IIVS vice president for outreach and education Kristie Sullivan was invited to participate in the 51st Annual meeting of the Japanese Society of Toxicology, in a session discussing the regulatory implementation of NAMs across Japan and the United States. Her presentation discussed the current state of the science of available NAMs and explored how to adapt validation practices to provide more flexibility and efficiency, while meeting regulatory needs, by thinking about methods and approaches as "valid for a purpose" rather than "validated" or "not validated". She also had an opportunity to meet with NIHS, JSAAE, CERI, and JACVAM colleagues to continue longstanding collaborations and forge new connections. Many thanks to everyone for kindness, hospitality, and shared scholarship and enthusiasm for 21st-Century Toxicology.

It is important for the in vitro community to assure that the test systems used in our methodologies are of a consistent quality to support the reproducibility of the test methods that rely on them. Whether you're using monolayer cells, co-cultures, 3D tissue constructs, ex vivo tissues, or a variety of other in vitro and in chemico systems, the Good In Vitro Method Practice guidelines have some helpful points for you to consider. Take a look at our poster from the last World Congress below for a summary and read through #GIVIMP for more detail.

Interested in learning more about the ToxTracker assay? This assay assesses a variety of potential mechanisms for genetic toxicity effects. We are holding a hands-on workshop next month--register now to get an in-depth look at the assay and how it can be used. 🗓 August 15-16, 2024 Gaithersburg, Md Virtual* and in-person spots are available, and complimentary registration for regulators. Contact us with any questions. Register here: https://lnkd.in/dU5Vhw8M *Virtual participation will be lectures only, not the lab portions of the workshop.

Register now for the webinar, “The CATMoS model for acute oral toxicity and evaluation of its potential use in a regulatory context for pesticide hazard and risk assessment,” happening August 28 from 11:00 am–12:30 pm ET and featuring Michael Lowit from the US Environmental Protection Agency (EPA) and Kamel Mansouri from the National Institute of Environmental Health Sciences (NIEHS). This is the fifth webinar in the EPIC series on the use of NAMs in risk assessment co-organized by the US Environmental Protection Agency (EPA), PETA Science Consortium International e.V., the Institute for In Vitro Sciences, Inc., and the California Department of Pesticide Regulation. Visit the PSCI website to register and access slides and video recordings of the previous webinars: https://bit.ly/3JX27Sc

IIVS was pleased to participate in the LiVE2024 meeting in Nice! This meeting focused on innovative and in cutting edge vitro respiratory research and catered to a spectrum of industries. Holger Behrsing presented a poster on "Fibrotic responses in human precision cut lung slices are maintained after cryopreservation". These exciting findings highlight the ability to maintain the fibrotic phenotype in preserved precision-cut lung slices, and provide researchers with a non-animal, human-derived model to study this debilitating disease.

If you want to learn more about this comprehensive assay, visit our website to register for a lab- and lecture- based training we are holding in August: www.iivs.org.

Have you heard the news? We have completed initial testing of INDIGO Biosciences, INC nuclear receptor kits at IIVS and the results look good! We have been working towards bringing these nuclear receptor assays to IIVS to provide testing for the endocrine disruptor potential of test samples by quantifying agonist and antagonist responses that they may exert against several human nuclear receptors.  With these positive results, we are ready to take orders for GLP compliant testing of the endpoints below and many more available from INDIGO Biosciences! Androgen Receptor (AR)  Estrogen Receptor (ERα)  Thyroid  Hormone Receptor Alpha (TRα)  Peroxisome Proliferator-Activated Receptor Alpha (PPARα)  Glucocorticoid Receptor (GR) Contact [email protected] for more information or to place a study to evaluate the endocrine distruption potential of your materials.

This week we hosted a group from K-Eco (https://www.keco.or.kr/en/) for a focused #PracticalMethodsTraining on strategies and laboratory techniques for skin sensitization testing. We certainly enjoyed hosting the team and wish everyone safe travels home.

Please join us in August for an in-depth workshop on the ToxTracker mechanistic genetic toxicity assay, developed by Toxys Inc. and offered by IIVS. The workshop will feature speakers from IIVS and Toys as well as guest speakers from our collaborators Corteva Agriscience and Procter & Gamble. August 15-16, 2025 Gaithersburg, Md Register and see the agenda here: https://lnkd.in/gFekUpbF

IIVS is a proud sponsor for the ASCCT and its annual meeting. We hope you will join us in submitting abstracts by the June 30 or Sept. 1 deadlines.