Hyde Engineering Consulting

Hyde-ing at the #courageclassicco Congratulations to Kerren Bergman and the ISPE Rocky Mountain Chapter #womeninpharma team! #courageclassicco #childrenshospital #worklifeharmony #getbusyliving #adventure #hydepride

A solid justification and rationale for soil and MOC selection in recovery studies is critical to establishing a compliant sampling program. Ensure readiness to defend your cleaning validation strategy. And if you’ve received an observation, work with the experts to accelerate your response. We’ve got your back. https://lnkd.in/grJ6phYC Nicole Collier Keith Bader John Hyde Michael Lund Linda Long #hydepride #cleanmatters #drugsafety #cleaningvalidation #cleaninplace #drugmanufacturing #FDAForm483

Kerren Bergman and David O'Keeffe, MS, MBA enjoying a table full of #hydepride with our amazing team in Pennsylvania last week! Thank you for all of your dedication and hard work👏 #teamwork #commissioning #qualification #engineering #wearehiring #employeeownership #ESOP

Let’s talk about Triton X-100. Triton X has been used for decades in drug development and manufacturing as a surfactant, for extraction of proteins, and in virus removal steps. Due to the severe pollution it causes in freshwater ecosystems and the significant threats it poses to wildlife, local authorities are regulating and enforcing measures to prevent this chemical from entering the environment through pharmaceutical waste streams. Our lab has experience developing rinse scale-up factors to determine the volume of water required for rinsing of Triton X from vessels for proper disposal. We use an established small-scale UHPLC rinse method along with vessel measurements and soiling scenarios to generate inputs for successful full-scale confirmation runs. The result is optimized water usage and confidence that Triton X is not introduced to the environment via wastewater. At Hyde, we believe #cleanmatters, for patients and for the planet. John Hyde Ronald Berk Keith Bader Linda Long Michael Lund #hydepride #cleaninplace #cleaningvalidation #HPLC #biopharmaceuticals #tritonx #watertesting #cycledevelopment #drugmanufacturing

#hydeing in Alaska! What a spectacular way to enjoy some well-deserved PTO….whale watching! #worklifeharmony #adventure #hydepride #whales #flexPTO #vacation #nofilter

Wishing our US clients and staff a safe, relaxing Fourth of July weekend🎆 🍉

Phosphoric acid is a common step in cleaning cycles, used for maintenance of the passive layer of stainless steel equipment and for preventing rouge. We know it works, but there is growing regulatory pressure to move away from the use of phosphates in an effort to reduce environmental impact. The Hyde Analytical Laboratory has used small-scale studies to demonstrate efficacy of phosphoric acid alternatives for maintenance of the stainless steel passive layer and for extension of vessel life. Hyde provides end-to-end support in implementing alternative chemistries to phosphoric acid. From assay development and cleaning agent screening through full-scale validation, we help our clients make the right change easy. Connect with us - We🧡talking rouge. John Hyde Keith Bader Ronald Berk Kathy Eley Fearghal Downey #sustainability #hydepride #rougeremoval #cleaningvalidation #cleaninplace #cycledevelopment #passivation #drugmanufacturing

While supporting a CIP Optimization project for a mAB Facility in Singapore, our team accomplished a staggering 67% reduction in water consumption, saving the site 100 million liters annually. The project leveraged small-scale cleaning studies through our laboratory, and optimization of CIP circuit designs and skid resequencing by our skilled team of on-site engineers. Improvements to cleaning processes yield a direct return on internal resources, and most critically, our most precious universal resource. Connect with a cleaning expert today: https://lnkd.in/gxG4yGri John Hyde Keith Bader Ronald Berk Kathy Eley Fearghal Downey #sustainability #hydepride #cleaningvalidation #cleaninplace #cycledevelopment #drugmanufacturing #waterconservation

Between 2011 and 2021, 188 endotoxin-related FDA Form 483s were issued to drug and device manufacturers. The FDA requires that endotoxin testing is performed for API and raw materials, container closure equipment, process intermediates, finished drug product, devices, and manufacturing equipment. Furthermore, the product must be validated to demonstrate that the product and matrix do not interfere with the endotoxin test. The Hyde Analytical Laboratory has introduced routine endotoxin, TOC, and HPLC analysis to help our clients reduce QC testing bottlenecks, making it easy to establish routine testing protocols that are compliant, risk-based, and put the patient first. Get to know our lab and reach out to an expert!: https://lnkd.in/gxG4yGri Michael Lund Nicole Collier Linda Long Keith Bader John Hyde #hydeanalyticallaboratory #endotoxin #qualitycontrol #483 #laboratory #cleaningvalidation #drugsafety

Where in the world is John Hyde? Today, he is with Will Czerniak outside of Gare de Lyon en route to the project site! #TGIF #hydepride #adventure #globalengineering #consulting #commissioning #qualification #localdelivery #subjectmatterexpert #cleaning #cleanmatters