Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex 🧠🐒 In this fascinating 2023 publication in Cell by Cell Press, Stereo-seq technology, in combination with a large-scale single nucleus RNA sequencing (snRNA-seq) analysis, was used to construct a comprehensive single-cell atlas for the entire macaque cortex. Thanks to Stereo-seq’s larger field-of-view (FOV) relative to other technologies, the study utilized up to 3 cm x 5 cm sized chips to map ~42 million cells from 161 sections of three macaque brains and capture detailed spatial information across extensive cortical regions. Key Highlights: • Using snRNA-seq and spatial transcriptomic analysis of 143 macaque cortical regions, Stereo-seq technology revealed the spatial distribution of 264 cell types and their marker genes across the entire cortex • Stereo-seq technology’s high-resolution spatial mapping revealed that regional density and composition of cell types were found to be coupled with cortical hierarchy, providing insights into cellular organization in the macaque brain • Integration of Stereo-seq technology with snRNA-seq enhanced the resolution and accuracy of cell-type identification and spatial distribution, enabling the discovery of primate-specific cell types that might be associated with the emergence of new cortical regions Read the full publication here >> https://lnkd.in/gD_hTbCi Learn more about Stereo-seq technology here >> https://lnkd.in/e6MjS-Z4 #BrainMapping #PrimateResearch #Neuroscience #StereoSeq #SpatialTranscriptomics #SingleCellAtlas #SpatialBiology
Complete Genomics
Biotechnology Research
San Jose, CA 33,820 followers
Driving genomics forward with complete sequencing solutions
About us
Complete Genomics is a pioneering life sciences company, headquartered in San Jose, California. Our mission is to drive genomics forward with complete sequencing solutions that improve lives. Since our establishment in 2005, we have consistently led the way in the development of high-throughput sequencing technology. Our extensive product lineup encompasses sample extraction, library preparation, lab automation, DNBSEQ sequencing, and data analysis. To learn more, visit www.completegenomics.com
- Website
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http://www.completegenomics.com
External link for Complete Genomics
- Industry
- Biotechnology Research
- Company size
- 201-500 employees
- Headquarters
- San Jose, CA
- Type
- Privately Held
- Founded
- 2005
- Specialties
- Whole Human Genome Sequencing, NGS, Life Science, and Research
Locations
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Primary
2904 Orchard Parkway
San Jose, CA 95134, US
Employees at Complete Genomics
Updates
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Complete Genomics reposted this
What an amazing turnout at The Bella located in the best biotech hub in the country (challenge me on that 😂)! Sold out multiple rounds of free tickets 🎟️ (over 200 in attendance) great weather, and the most amazing compliments around our efforts to rebuild the biotech community network we had pre-COVID. Thank you Professor Trey Ideker and The Duvets, NanoCellect Biomedical, Inc. Defined Bioscience Molecular Assemblies, Inc. ▶ Stephane Richard with French BioBeach and Complete Genomics for sponsoring. We shouldn’t only be helping out our communities through the good times! Follow us and stay tuned for the next one !!
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Complete Genomics reposted this
LAST CHANCE! GEN Chat: Complete Genomics’ Rade Drmanac Talks NGS Then and Now In this inaugural GEN chat webinar TODAY, Dr. Radoje Drmanac sits down with Dr. Julianna LeMieux (Deputy Editor in Chief, GEN) for a candid conversation about all things NGS. Register now to join us for this free webinar sponsored by MGI: https://ow.ly/hht350SKXA5 #Omics
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Our latest application note, “Pathogen & Drug Resistance Gene Detection with HGT tNGS Solution and Complete Genomics DNBSEQ-E25 Sequencer,” showcases the powerful capabilities of our DNBSEQ-E25 sequencing platform for targeted next-generation sequencing (tNGS). This workflow offers an exciting solution for pathogen detection and drug resistance gene analysis, including: • Superior detection of 330 clinically common pathogens and 150 drug resistance genes • A rapid sample-to-report workflow that takes just 11 hours • High-quality sequencing (Q30 > 93%) that produces reliable, accurate, and reproducible data for comprehensive pathogen identification • A portable, cost-effective solution with the all-in-one DNBSEQ-E25 sequencer for both lab and field use Read the app note here >> https://lnkd.in/gUBe66sp Learn more about DNBSEQ-E25 here >> https://lnkd.in/gSDkAMFM Learn more about our end-to-end NGS microbiology solutions here >> https://lnkd.in/gSGDafzd #Microbiology #Metagenomics #16SSequencing #tNGS #NGS #Biotechnology
App Note: Pathogen & Drug Resistance Gene Detection with HGT tNGS Solution and Complete Genomics DNBSEQ-E25 Sequencer
completegenomics.com
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Complete Genomics reposted this
NEW GEN Chat! Complete Genomics’ Rade Drmanac Talks NGS Then and Now Wednesday, August 7, 2024 9:00 am PT, 12:00 pm ET, 18:00 CET In this inaugural GEN chat webinar, Dr. Radoje Drmanac sits down with Dr. Julianna LeMieux (Deputy Editor in Chief, GEN) for a candid conversation about all things NGS. Register now to join us for this free webinar sponsored by MGI: https://ow.ly/fMJw50SKXxH #Omics
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Stereo-seq reveals cell-type heterogeneity and developmental dynamics in mouse organogenesis 🧬 🐁 In this publication from Cell Press, a spatiotemporal transcriptomic atlas of mouse organogenesis was generated with Stereo-seq technology to gain insight into the molecular basis of spatial cell heterogeneity and cell fate specification in developing tissues. It also allowed spatial visualization of gene expression related to human developmental disorders. With Stereo-seq technology enabling large field-of-view spatial transcriptomics at cellular resolution, this study was able to: • Reveal 25 major cell types based on known markers and further identified cell subtypes or cell states for epithelial cell and chondrocyte populations in whole mouse embryo. • Identify differentially expressed genes linked to cell fate divergence of radial glia cells to neuroblasts and glioblasts. It also identified transcription factors associated with lineage commitment. This provides insights into progenitor cell specification in the developing dorsal midbrain. • Construct a spatial transcriptomic map across multiple developmental timepoints with the help of a developmental disorders genotype-to-phenotype database. This information can be used to elucidate the mechanisms underlying phenotypic features in Robinow Syndrome or other disorders. Read the full publication here >> https://lnkd.in/gkSA6aYD And learn more about Stereo-seq here, the spatial technology with a smaller spot size, higher resolution, larger capture area, and more spots per 100 μm than the leading competition >> https://lnkd.in/gcB3NjP3 #SpatialTranscriptomics #Stereoseq #CellBiology #DevelopmentalBiology #Organogenesis #DNBSEQ #NGS
Spatiotemporal transcriptomic atlas of mouse organogenesis using DNBSEQ technology – Cell
completegenomics.com
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Interested in more than metagenomics? Complete Genomics has a robust offering of end-to-end NGS solutions for microbiology applications in clinical research, veterinary science, food safety, and environmental testing. Check out our DNBSEQ-driven workflows here to learn how you can achieve fast, accurate, cost-effective sequencing results. ‣ Precisely identify and profile diverse microbial communities with 16S rDNA Sequencing ‣ Detect common pathogens and drug resistant genes with our tNGS workflow ‣ Utilize shotgun metagenomics to gain insights into the microbial ecosystem ‣ Easily run 3rd party panels on our DNBSEQ sequencers Learn more >> https://lnkd.in/ggPzxBMH #Microbiology #Metagenomics #16SSequencing #tNGS #NGS #Biotechnology
Complete NGS Solutions for Microbiology
completegenomics.com
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DNBSEQ technology is powering research in metagenomics with huge implications for the future of personalized medicine. In this webinar, Dr. Maike Seifert of the Karolinska Institutet shares how she utilized Complete Genomics’ end-to-end solutions — from lab automation (STP-7000 and SP-100) to DNBSEQ sequencers (G400 and T7) — for her metagenomics projects. Her work includes studying microbes in the gut mucosa and gut microbiome to improve the diagnosis and treatment of IBD, diverticulitis, and polyps/tumors. Dr. Seifert also discussed the fascinating Swedish Microbiome Project, the largest pregnancy microbiome cohort in the world, which uses DNBSEQ workflows to assess the association between the maternal microbiome during pregnancy and post-partum and the risk of maternal and neonatal adverse events. Watch the full on-demand webinar here >> https://lnkd.in/gDtewSJC #Metagenomics #Microbiome #IBD #Diverticulitis #PersonalizedMedicine #DNBSEQ #Microbiology
Exploring the Future of Personalized Medicine: Dr. Maike Seifert on DNBSEQ-Powered Metagenomics Research and the Swedish Microbiome Project
completegenomics.com
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If you enjoyed our on-demand webinar on spatial heterogeneity in ovarian cancer >> https://lnkd.in/gxdrkVKk or the recent spatial transcriptomics benchmarking study in Nature Methods >> https://lnkd.in/ggbtwjDt be sure to check out this application note in which Stereo-seq technology and the DNBSEQ-T7 sequencer were used to create a high-resolution spatiotemporal transcriptomic atlas of zebrafish embryogenesis >> https://lnkd.in/gh_8heAa With unparalleled field-of-view and subcellular resolution, Stereo-seq is a game-changing spatial technology for understanding complex biological processes across various applications. From cancer research to developmental biology, Stereo-seq pairs with DNBSEQ technology to provide detailed spatial and temporal insights like never before. Click here to learn more about our spatial transcriptomics solutions >> https://lnkd.in/g6aA7NMd #Stereoseq #DNBSEQ #SpatialTranscriptomics #SpatialBiology #DevelopmentalBiology #CancerResearch #Biotech
App Note: Construction of a Spatiotemporal Transcriptomic Atlas of Zebrafish Embryogenesis Using the DNBSEQ-T7 Sequencer
completegenomics.com
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Complete Genomics recently joined the American Society of Human Genetics' Industry Roundtable program aimed at speeding the discovery and application of genetics and genomics. Press release 👉 https://lnkd.in/eYajVv-Y #ASHG #HumanGenetics
ASHG Launches Roundtable with Industry Partners
https://www.ashg.org