When using #hepatocytes to conduct #ADME, #toxicology or other studies, proper thawing and plating is critical to ensuring your data is as accurate as possible. Take a look at this instructional video for useful information and tips to maximize the performance of your cells: https://hubs.ly/Q02HqVjS0
About us
BioIVT, formerly BioreclamationIVT, is a leading global provider of high-quality biological specimens and value-added services. We specialize in control and disease state samples including human and animal tissues, cell products, blood and other biofluids. Our unmatched portfolio of clinical specimens directly supports precision medicine research and the effort to improve patient outcomes by coupling comprehensive clinical data with donor samples. Our Research Services team works collaboratively with clients to provide in vitro hepatic modeling solutions. And as the world’s premier supplier of ADME-Tox model systems, including hepatocytes and subcellular fractions, BioIVT enables scientists to better understand the pharmacokinetics and drug metabolism of newly discovered compounds and the effects on disease processes. By combining our technical expertise, exceptional customer service, and unparalleled access to biological specimens, BioIVT serves the research community as a trusted partner in ELEVATING SCIENCE®.
- Website
-
http://www.bioivt.com/
External link for BioIVT
- Industry
- Biotechnology Research
- Company size
- 501-1,000 employees
- Headquarters
- Hicksville, NY
- Type
- Privately Held
- Specialties
- Human and Animal Biologicals of the highest quality, Customized for every individual order, High level of customer service, Products delivered in a timely matter, ready for use, and Unconditional product guarantee
Locations
-
Primary
Post Office Box 770
Hicksville, NY 11802, US
Employees at BioIVT
Updates
-
Are you attending #ADLM2024? Reach out to Brandon Praslicka, Katherine Osborn, Kevin King, Cathie Miller, Darren Lowenthal & Cole Taft or visit us at booth 1005 to discuss your research needs for normal and disease state #biospecimens including whole blood plasma and serum from any commercially available species; clinically collected human material including remnants representing a broad spectrum of indications; and donor center collected quality control matrices.
-
-
Next-generation #sequencing (NGS) can provide valuable data and the confidence that you’re identifying the precise samples you need, so how does it work? BioIVT has 10,000 #biospecimens with mutation data already in our repository, including specific point mutations, fusions, copy number variations (CNV), etc., and hundreds more are screened by NGS every month. You can receive a custom-tailored inventory report to view what’s currently available: https://lnkd.in/eg5e43_6 Alternatively, we can combine our expertise in human tissue procurement, specimen selection, sample preparation and project management to provide NGS services complete with extraction, library preparation, sequencing and bioinformatics: https://lnkd.in/e9Yg_uks Reach out to our team today to discuss your needs and which option is right for you: https://lnkd.in/ea5Qw2pE #mutations #diagnostics #biomarkers #bioinformatics
-
-
This #WorldBrainDay 2024, we want to highlight the significance of diversity and sample reliability in neurology research. A reported 50% of preclinical studies are irreplicable. This significant waste of time and resources is estimated to cost the United States $28 billion annually. One contributing factor is the use of #biospecimens that do not accurately represent the patient population. Additionally, many research studies categorize samples as "normal" when donors may have undetected or unknown pathologies. These practices introduce bias and inaccuracies into research, leading to unreliable results and hindering progress in the field. At BioIVT, we recognize the importance of sample diversity and quality in supporting neuro research and remain committed to providing the world's largest private repository of human #cerebrospinal fluid (CSF). This means you have access to a diverse pool of reliable biospecimens that are vital to enhancing the generalizability of study outcomes and ensuring that new treatments can benefit everyone. Samples are available across age, gender, and ethnicity, offering unmatched quality and reliability in biospecimen sourcing. Learn more about our available CSF samples for research: https://hubs.ly/Q02HqQbN0 #BrainDay2024 #DiversityInResearch #Neurology
-
The ICH M12 #DrugInteractions Guideline has been finalized and global regulatory agencies are already adopting it. Are you? The new Guideline replaces the corresponding guidance documents from the US FDA, EMA, and PMDA, among others. Join us tomorrow to hear DDI expert, Dr. Brian Ogilvie, discuss what’s new and how to plan your drug development strategies: https://hubs.ly/Q02HqM580 #DrugDevelopment #ADME #DMPK #Enzymes #DrugTransporters
LIVE Webinar: Highlights From the Final ICH M12 Guideline “Drug Interaction Studies” — What’s changed and considerations for your IND programs
info.bioivt.com
-
The #scientificposter we presented at the #MicrophysiologicalSystems World Summit last month is now available. It demonstrates the utility of #HEPATOPAC for generating #siRNA mediated isogenic pairs for both #ADME and target screening applications. siRNA knockdown can be utilized to explore ADME-Tox related gene function in a well differentiated #hepatocyte model. Gene Knockdown in HEPATOPAC can be used to assess the effects of gene function on disease state modeling such as #MASLD and validate potential therapeutic modalities. #GalNAc conjugated siRNA can be utilized in the HEPATOPAC model and uptake and knockdown from these treatments is #ASGPR expression dependent. View the poster: https://hubs.ly/Q02GFHn00
Optimization of siRNA Delivery in a Long-Term Hepatic Micropatterned Co-Culture (HEPATOPAC) | BioIVT Educational Content
bioivt.com
-
#Diabetes increases the risk of heart failure by causing the death of heart muscle cells, potentially through a process called #ferroptosis. However, the exact role of ferroptosis in heart failure is not well understood. A recent study investigated ferroptosis by comparing heart tissue samples from people with diabetic heart failure to those from healthy individuals using de-identified heart tissue samples obtained from BioIVT. The study confirmed that cardiac ferroptosis plays a significant role in heart failure among people with diabetes. It also shed light on the molecular mechanisms involved, suggesting potential therapeutic targets to help manage heart failure complications in diabetic patients. Read the full study to learn more: https://hubs.ly/Q02Gy28T0 #HeartFailure #Research #HeartHealth
Regulation of cardiac ferroptosis in diabetic human heart failure: uncovering molecular pathways and key targets - Cell Death Discovery
nature.com
-
It’s critical that the correct species are selected for #preclinical #toxicology studies to accurately evaluate the safety of an NCE before it progresses to human clinical trials. Understanding the metabolic pathways of the NCE in different species #invitro increases the likelihood that the findings will be applicable to human safety. Learn more about in vitro cross-species comparison: https://hubs.ly/Q02Gy0190 #DrugMetabolism #ADME #DMPK
Metabolism: A Critical Factor in Species Selection for Nonclinical Toxicology Studies
bioivt.com
-
A lack of basic data accompanying #biospecimens prevents researchers from ensuring relevancy and quality during procurement as well as eventual reproducibility, calling the results of critical research into question. Read about the importance of and ways to utilize basic data to help ensure the accuracy of your research, including several case studies highlighting its impact: https://lnkd.in/eBMVSQSw #Pharma #Biotech #DrugDiscovery #Research
-
-
Next week, DDI expert Dr. Brian Ogilvie will be discussing the impacts of the newly finalized ICH M12 on #invitro #druginteractions study design and interpretation. The Guideline replaces corresponding guidance documents from the US FDA, EMA, and PMDA, among others. Make sure your studies meet these new regulatory expectations – learn more and register now: https://hubs.ly/Q02GxZFD0 #ADME #DMPK #DrugMetabolism #Enzymes #DrugTransporters
-