In a recent study, AGC Biologics' R&D team in Japan compared high- and low-producing CHO cell clones of two types of antibodies to explore the factors involved in antibody productivity. The antibody productivity of CHO cells is influenced by their tolerance to endoplasmic reticulum (ER) stress. High-producing clones exhibited greater ER stress tolerance, leading to increased productivity. This research highlights the importance of managing ER stress in optimizing antibody production. Download the full paper to explore detailed findings and implications for biopharmaceutical manufacturing. Find the link in the comments. #biotech #pharmaceuticals #LifeScience #Biotechnology #advancedtherapies #Biopharmaceuticals #biopharma #pharma #AGCBio #CDMO
AGC Biologics
Biotechnology Research
Bothell, WA 97,979 followers
We work side by side with our customers to improve patients’ lives by bringing new biopharmaceutical products to market.
About us
AGC Biologics offers deep industry expertise and uniquely customized services for the scale-up and cGMP manufacture of protein-based therapeutics (using mammalian and microbial systems), mRNA, pDNA, viral vector and cell therapy products, from pre-clinical to commercial production, including our proprietary CHEF1TM Expression System for efficient protein production with CHO cells. Our company DNA drives us to provide innovative solutions to partner with our customers in helping them reach their goals and accelerate their projects at our cGMP-compliant facilities in the US, Europe and Japan, as well as to facilitate approval and manage spending during the product lifecycle. We forge exceptionally strong partnerships with our customers and we never lose sight of our commitment to deliver reliable and compliant drug substance. Visit www.agcbio.com to learn more.
- Website
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http://www.agcbio.com
External link for AGC Biologics
- Industry
- Biotechnology Research
- Company size
- 1,001-5,000 employees
- Headquarters
- Bothell, WA
- Type
- Public Company
- Specialties
- Mammalian Cell Line Development, Microbial Cell Line Development, Upstream Process Development, Downstream Process Development, Analytical Development, Formulation Development, cGMP Manufacturing, GMP Stability Studies and Storage, CHEF1 Expression System, Perfusion, Gene Therapy, Viral Vector, Cell Therapy, pDNA, plasmidDNA, mRNA, and Advanced Therapy
Locations
Employees at AGC Biologics
Updates
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AGC Biologics recently transitioned the upstream bioprocess for monoclonal and bi-specific antibodies from the Thermo SUB to the Cytiva Xcellerex Reactor. Through rigorous pilot studies, validation tests, and real-time CO2 monitoring, we ensured process integrity and met all key quality benchmarks. This move not only enhanced production but also set the stage for future innovations. Discover how these strategic transitions are reshaping the industry and driving success in the full case study. https://lnkd.in/gphUncvu #biotech #pharmaceuticals #LifeScience #Biotechnology #advancedtherapies #Biopharmaceuticals #biopharma #pharma #AGCBio #CDMO
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AGC Biologics SME Video Series 🔬 👩🔬 Discover how AGC Biologics is revolutionizing cell and gene therapy! From seamless development to manufacturing, our team ensures rapid market advancement. With expertise in multiple cell types and cutting-edge technologies, we provide robust processes tailored for success. Dive into our innovative approach and learn how we make therapies safer and more effective. Watch the full video to see our commitment to excellence in action! https://lnkd.in/gDzSPDXs #biotech #pharmaceuticals #LifeScience #Biotechnology #advancedtherapies #Biopharmaceuticals #biopharma #pharma #AGCBio #CDMO #celltherapy #genetherapy Meghan Nelson
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AGC Biologics and NEC Corporation's Bio Therapeutics have partnered to produce NECVAX-NEO1, an orally delivered, bacteria-based DNA vaccine targeting patient-specific tumor neoantigens. This collaboration aims to enhance personalized cancer treatment production, leveraging the biotechnological strengths of both companies. The partnership will focus on clinical development and GMP-compliant manufacturing in Germany, with clinical trials set to begin in 2024 and 2025. Read the full press release here: https://lnkd.in/gF_KE7tg #biotech #pharmaceuticals #LifeScience #Biotechnology #advancedtherapies #Biopharmaceuticals #biopharma #pharma #AGCBio #CDMO
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Unlock the future of biopharmaceuticals with AGC Biologics' process for concentrating and purifying LVVs. In collaboration with ORCHARD THERAPEUTICS LIMITED, this scalable process achieves viral titers up to 2E 09 TU/mL, balancing impurity removal and vector recovery. From optimized filtration to innovative chromatographic techniques, discover how these breakthroughs could transform gene therapies. Download the full research poster to dive into the details. Link in comments. #biotech #pharmaceuticals #LifeScience #Biotechnology #advancedtherapies #Biopharmaceuticals #biopharma #pharma #AGCBio #CDMO #LVV #celltherapy #genetherapy
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This week, we are shining the #FridayFeature spotlight on Watson Neto, Director of Process Transfer at our Copenhagen site. Watson will celebrate his five-year anniversary at AGC Biologics this October. Over his tenure, he has been instrumental in several development, restructuring, and optimization projects, seeing our Copenhagen team more than double in size. Watson feels most connected to our Core Value of #Trust, as it underpins all our other Core Values. He shares, “As an individual, you can have all the knowledge, but you need to feel that you are in a trusting environment to be confident and comfortable sharing that knowledge.” Thank you for everything you do, Watson! And thank you for your continuous focus on creating trusting environments for your team members. #AGCBiologics #MSAT #ProcessTransfer #EmployeeSpotlight #Trust
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AGC Biologics recently expanded our Heidelberg site, adding advanced storage solutions, state-of-the-art labs, and cutting-edge manufacturing technologies. Check out our expansion highlight video for an in-depth look at how these exciting updates will revolutionize our microbial, mRNA, and pDNA production. Don’t miss out on this behind-the-scenes glimpse into Heidelberg! #biotech #pharma #Biopharma #pharmaceuticals #LifeScience #Biotechnology #biologics #Biopharmaceuticals #AGCBio #CDMO #mrna #pdna #microbial Dieter Kramer
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Join AGC Biologics' CBO, Christoph Winterhalter, for Endpoints News Manufacturing Day 2024 on August 6. Christoph will be participating in the Global Tensions, Local Opportunities panel focusing on the BIOSECURE Act, China’s stricter espionage laws, and Covid-like disruptions. The panel will discuss the challenges biopharma companies are facing, like reevaluating their supply chains to move operations closer to home. Join the panelists from 11:00 AM - 11:30 AM ET. Register now! https://lnkd.in/e-VZNkvX #biotech #pharma #Biopharma #pharmaceuticals #LifeScience #Biotechnology #biologics #Biopharmaceuticals #AGCBio #CDMO #supplychainmanagement #BIOSecureAct
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Choosing the right CDMO for microbial manufacturing is crucial - but are you overlooking key factors that could make or break your project's success? Discover the five essential tips most developers miss, from process flexibility to the hidden pitfalls of regulatory compliance. Uncover the secrets to ensuring your microbial production thrives. Don’t miss out on these game-changing insights! Check the link in the comments for the full blog. #biotech #pharma #Biopharma #pharmaceuticals #LifeScience #Biotechnology #biologics #Biopharmaceuticals #AGCBio #CDMO #mammalian #microbial
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AGC Biologics' Seattle Campus achieved a major regulatory milestone in March 2024, passing an FDA multi-product inspection, leading to the approval of two new products for commercial production. This success marks a significant leap in biopharmaceutical innovation. How did we do it, and what’s next for AGC Biologics? Read the full press release to uncover the details behind this achievement. https://lnkd.in/gc_qKbvn #biotech #pharma #Biopharma #pharmaceuticals #LifeScience #Biotechnology #biologics #Biopharmaceuticals #AGCBio #CDMO #celltherapy #mammalian #microbial
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