Among the locations the player can visit are the firehouse and the apartment building from Ghostbusters (1984), the soup restaurant from Seinfeld (1989), Jessica Jones' office, Matt Murdock's law offices, and the Insomniac Games studio.
Every time Spider-Man throws an enemy off a building, no matter by which means, they never hit the ground. Instead, they get automatically webbed against the wall. This was done to contribute to Spider-Man's "no-kill" rule.
Some of the characters in the game are modeled after their real-life actor counterparts.
Insomniac says that this game is the first in a Marvel Gaming Universe, as they have plans to make more Marvel games.